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Title: | Transarterial Radioembolization Following Chemoembolization for Unresectable Hepatocellular Carcinoma: Response Based on Apparent Diffusion Coefficient Change is an Independent Predictor for Survival | Authors: | Klompenhouwer, Elisabeth G. Dresen, Raphaela C. Verslype, Chris LAENEN, Annouschka Bonne, Lawrence Vandecaveye, Vincent Maleux, Geert |
Issue Date: | 2018 | Publisher: | SPRINGER | Source: | CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY, 41(11), p. 1716-1726 | Abstract: | PurposeTo evaluate whether response based on contrast-enhanced magnetic resonance imaging (MRI) and apparent diffusion coefficient (ADC) change at diffusion-weighted MRI after transarterial radioembolization (TARE) can predict survival, in patients with prior transarterial chemoembolization with drug-eluting beads (DEB-TACE) for hepatocellular carcinoma (HCC).MethodsWe identified all patients who received DEB-TACE prior to TARE for HCC between 2007 and 2016. Response on MRI was determined by modified RECIST (mRECIST) and ADC change relative to pre-TARE imaging (ADCratio). Kaplan-Meier and log-rank tests were used to correlate the response/disease and treatment variables to overall survival. Multivariable Cox regression models were used to correct for confounders.ResultsA total of 29 consecutive patients were included. Univariable analysis showed that response determined by mRECIST was a nonsignificant predictor of survival (p=0.057), and response determined by ADCratio was a significant predictor of survival (p=0.011). Number of prior DEB-TACE procedures (p=0.037), female gender (p<0.001) and BCLC C (p=0.03) were related to worse survival. The number of prior DEB-TACE procedure was significantly higher in non-responders determined by ADCratio (p=0.028). Multivariable analyses showed that response based on ADCratio was an independent predictor of survival (p=0.041).ConclusionADCratio following TARE is an independent predictor for survival in patients who previously underwent DEB-TACE for HCC. | Notes: | [Klompenhouwer, Elisabeth G.; Dresen, Raphaela C.; Bonne, Lawrence; Vandecaveye, Vincent; Maleux, Geert] Univ Hosp Leuven, Dept Radiol, Herestr 49, B-3000 Louvain, Belgium. [Klompenhouwer, Elisabeth G.] Netherlands Canc Inst, Dept Radiol, Plesmanlaan 121, NL-1066 CX Amsterdam, Netherlands. [Verslype, Chris] Univ Hosp Leuven, Dept Digest Oncol, Herestr 49, B-3000 Louvain, Belgium. [Laenen, Annouschka] KU Leuven Univ Hasselt, Dept Biostat & Stat Bioinformat, Kapucijnenvoer 35, B-3000 Louvain, Belgium. | Keywords: | Radioembolization; Chemoembolization; Magnetic resonance imaging; Diffusion-weighted imaging; Survival analysis; Follow-up studies;Radioembolization; Chemoembolization; Magnetic resonance imaging ; Diffusion-weighted imaging; Survival analysis; Follow-up studies | Document URI: | http://hdl.handle.net/1942/28717 | ISSN: | 0174-1551 | e-ISSN: | 1432-086X | DOI: | 10.1007/s00270-018-1991-3 | ISI #: | 000451930300010 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2019 |
Appears in Collections: | Research publications |
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