Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/28755
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dc.contributor.authorScharmga, A.-
dc.contributor.authorGEUSENS, Piet-
dc.contributor.authorPeters, Martijn-
dc.contributor.authorVAN DEN BERGH, Joop-
dc.contributor.authorLoeffen, D.-
dc.contributor.authorSchoonbrood, T.-
dc.contributor.authorvan Rietbergen, B.-
dc.contributor.authorVosse, D.-
dc.contributor.authorWeijers, R.-
dc.contributor.authorvan Tubergen, A.-
dc.date.accessioned2019-07-17T12:20:31Z-
dc.date.available2019-07-17T12:20:31Z-
dc.date.issued2018-
dc.identifier.citationScandinavian journal of rheumatology (Trykt. utg.), 47(6), p. 431-439-
dc.identifier.issn0300-9742-
dc.identifier.urihttp://hdl.handle.net/1942/28755-
dc.description.abstractObjectives: To study the relationship between structural damage and inflammatory features on magnetic resonance imaging (MRI) or radiography and other risk factors [anti-citrullinated protein antibody (ACPA) and/or rheumatoid factor (RF) seropositivity, hand dominance, disease duration] and the presence or number of cortical interruptions in finger joints on high-resolution peripheral quantitative computed tomography (HR-pQCT). Method: Finger joints of 38 healthy subjects and 39 patients with rheumatoid arthritis (RA) were examined through radiographs, MRI, and HR-pQCT. Radiographs were scored according to the Sharp/van der Heijde (SvH) method; MRI for the presence of cortical interruptions, bone marrow oedema (BMO), and synovitis; and HR-pQCT images for cortical interruptions. Descriptive statistics were calculated and associations examined using generalized estimating equations. Results: Cortical interruptions were found in healthy subjects and patients with RA on HR-pQCT (mean +/- sd 0.33 +/- 0.63 vs 0.38 +/- 0.64 per joint quadrant, respectively, p < 0.01). Structural damage on MRI (cortical interruptions) or radiographs (SvH >= 1) was associated with the presence of cortical interruptions on HR-pQCT [odds ratio (OR) 12.4, 95% confidence interval (CI) 7.5-21.4, p < 0.01 and OR 4.8, 95% CI 1.9-11.7, respectively, p < 0.01]. The presence of BMO or synovitis was associated with more cortical interruptions on HR-pQCT (beta 0.47, 95% CI 0.4-0.6, p < 0.01 and beta 1.9, 95% CI 0.6-3.1, p < 0.01). In patients with RA, ACPA, and/or RF seropositivity, hand dominance and disease duration were not associated with more cortical interruptions on HR-pQCT. Conclusion: Structural damage and inflammatory features on MRI and radiographs are associated with cortical interruptions on HR-pQCT. No association between other risk factors and cortical interruptions was demonstrated.-
dc.description.sponsorshipThis study was funded by an unrestricted grant from Pfizer and the Weijerhorst Foundation.-
dc.language.isoen-
dc.publisherTAYLOR & FRANCIS LTD-
dc.rights2018 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/ licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.-
dc.titleStructural damage and inflammation on radiographs or magnetic resonance imaging are associated with cortical interruptions on high-resolution peripheral quantitative computed tomography: a study in finger joints of patients with rheumatoid arthritis and healthy subjects-
dc.typeJournal Contribution-
dc.identifier.epage439-
dc.identifier.issue6-
dc.identifier.spage431-
dc.identifier.volume47-
local.format.pages9-
local.bibliographicCitation.jcatA1-
dc.description.notes[Scharmga, A.; Geusens, P.; Peters, M.; van den Bergh, J. P.; Schoonbrood, T.; Vosse, D.; van Tubergen, A.] Maastricht Univ, Med Ctr, Div Rheumatol, Dept Med, POB 5800, NL-6202 AZ Maastricht, Netherlands. [Scharmga, A.; Peters, M.; van den Bergh, J. P.] Maastricht Univ, NUTRIM Sch Nutr & Translat Res Metab, Maastricht, Netherlands. [Scharmga, A.; Geusens, P.; Peters, M.; van Tubergen, A.] Maastricht Univ, CAPHRI Care & Publ Hlth Res Inst, Maastricht, Netherlands. [Geusens, P.; van den Bergh, J. P.] Viecuri Med Ctr, Dept Internal Med, Venlo, Netherlands. [van den Bergh, J. P.] Hasselt Univ, Fac Med & Life Sci, Hasselt, Belgium. [Loeffen, D.; Weijers, R.] Maastricht Univ, Med Ctr, Dept Radiol, Maastricht, Netherlands. [van Rietbergen, B.] Eindhoven Univ Technol, Dept Biomed Engn, Eindhoven, Netherlands. [van Rietbergen, B.] Maastricht Univ, Med Ctr, Dept Orthopaed Surg, Maastricht, Netherlands.-
local.publisher.placeABINGDON-
local.type.refereedRefereed-
local.type.specifiedArticle-
dc.identifier.doi10.1080/03009742.2018.1424234-
dc.identifier.isi000451689300001-
item.fulltextWith Fulltext-
item.fullcitationScharmga, A.; GEUSENS, Piet; Peters, Martijn; VAN DEN BERGH, Joop; Loeffen, D.; Schoonbrood, T.; van Rietbergen, B.; Vosse, D.; Weijers, R. & van Tubergen, A. (2018) Structural damage and inflammation on radiographs or magnetic resonance imaging are associated with cortical interruptions on high-resolution peripheral quantitative computed tomography: a study in finger joints of patients with rheumatoid arthritis and healthy subjects. In: Scandinavian journal of rheumatology (Trykt. utg.), 47(6), p. 431-439.-
item.contributorScharmga, A.-
item.contributorGEUSENS, Piet-
item.contributorPeters, Martijn-
item.contributorVAN DEN BERGH, Joop-
item.contributorLoeffen, D.-
item.contributorSchoonbrood, T.-
item.contributorvan Rietbergen, B.-
item.contributorVosse, D.-
item.contributorWeijers, R.-
item.contributorvan Tubergen, A.-
item.validationecoom 2019-
item.accessRightsOpen Access-
crisitem.journal.issn0300-9742-
crisitem.journal.eissn1502-7732-
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