Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/28868
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Minnee, R. C. | - |
dc.contributor.author | FIEUWS, Steffen | - |
dc.contributor.author | Jochmans, I. | - |
dc.contributor.author | Aerts, R. | - |
dc.contributor.author | Barriga, M. Sainz | - |
dc.contributor.author | Debaveye, Y. | - |
dc.contributor.author | Maertens, J. | - |
dc.contributor.author | Vandenberghe, P. | - |
dc.contributor.author | Laleman, W. | - |
dc.contributor.author | van der Merwe, S. | - |
dc.contributor.author | Verslype, C. | - |
dc.contributor.author | CASSIMAN, David | - |
dc.contributor.author | Ferdinande, P. | - |
dc.contributor.author | Nevens, F. | - |
dc.contributor.author | Pirenne, J. | - |
dc.contributor.author | Monbaliu, D. | - |
dc.date.accessioned | 2019-08-05T12:57:51Z | - |
dc.date.available | 2019-08-05T12:57:51Z | - |
dc.date.issued | 2018 | - |
dc.identifier.citation | AMERICAN JOURNAL OF TRANSPLANTATION, 18(12), p. 3007-3020 | - |
dc.identifier.issn | 1600-6135 | - |
dc.identifier.uri | http://hdl.handle.net/1942/28868 | - |
dc.description.abstract | Acute graft-versus-host disease (GVHD) after liver transplant (LTx) is a rare complication with a high mortality rate. Recently, monoclonal antibody (mAb) treatment, specifically with anti-interleukin 2 receptor antibodies (IL2RAb) and anti-tumor necrosis factor-alpha antibodies (TNFAb), has gained increasing interest. However, evidence is mostly limited to case reports and the efficacy remains unclear. Here, we describe 5 patients with LTx-associated GVHD from our center and provide the results of our systematic literature review to evaluate the potential therapeutic benefit of IL2RAb/TNFAb treatment. Of the combined population of 155 patients (5 in our center and 150 through systematic search), 24 were given mAb (15.5%)-4 with TNFAb (2.6%) and 17 with IL2RAb (11%) ("mAb group")-and compared with patients who received other treatments (referred to as "no-mAb group"). Two-sided Fisher exact tests revealed a better survival when comparing treatment with mAb versus no-mAb (11/24 vs 27/131; P = .018), TNFAb versus no-mAb (3/4 vs 27/131; P = .034), and IL2RAb versus no-mAb (8/17 vs 27/131; P = .029). This systematic review suggests a beneficial effect of mAb treatment and a promising role for TNFAb and IL2RAb as a first-line strategy to treat LTx-associated acute GVHD. | - |
dc.description.sponsorship | A Grant for Investigator Sponsored Research from Astellas, Belgium, partly supported this work. IJ, DM, and JP are holders of a KU Leuven named chair from the Centrale Afdeling voor Fractionering, Belgium. JP holds a KU Leuven named chair from the Institute George Lopez-group. DM, SvdM, FN, and GM are senior clinical investigators of the research foundation Flanders, Belgium (FWO). | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.rights | 2018 The American Society of Transplantation and the American Society of Transplant Surgeons | - |
dc.subject.other | clinical research/practice; complication; graft-versus-host disease (GVHD); liver transplantation/hepatology | - |
dc.subject.other | clinical research/practice; complication; graft-versus-host disease (GVHD); liver transplantation/hepatology | - |
dc.title | Improved survival after LTx-associated acute GVHD with mAb therapy targeting IL2RAb and soluble TNFAb: Single-center experience and systematic review | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 3020 | - |
dc.identifier.issue | 12 | - |
dc.identifier.spage | 3007 | - |
dc.identifier.volume | 18 | - |
local.format.pages | 14 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Minnee, R. C.; Jochmans, I.; Aerts, R.; Barriga, M. Sainz; Pirenne, J.; Monbaliu, D.] Univ Hosp Leuven, Abdominal Transplant Surg & Transplantat Coordina, Leuven, Belgium. [Minnee, R. C.; Jochmans, I.; Aerts, R.; Barriga, M. Sainz; Pirenne, J.; Monbaliu, D.] Katholieke Univ Leuven, Dept Microbiol & Immunol, Leuven, Belgium. [Fieuws, S.] Univ Leuven, KU Leuven, Interuniv Inst Biostat & Stat Bioinformat, Leuven, Belgium. [Fieuws, S.] Univ Hasselt, Hasselt, Belgium. [Debaveye, Y.; Ferdinande, P.] Univ Hosp Leuven, Dept Intens Care Med, Leuven, Belgium. [Debaveye, Y.; Ferdinande, P.] Katholieke Univ Leuven, Div Cellular & Mol Med, Lab Intens Care Med, Leuven, Belgium. [Maertens, J.; Vandenberghe, P.] Univ Hosp Leuven, Dept Hematol, Leuven, Belgium. [Vandenberghe, P.] Univ Hosp Leuven, Ctr Human Genet, Leuven, Belgium. [Laleman, W.; van der Merwe, S.; Verslype, C.; Cassiman, D.; Nevens, F.] Univ Hosp Leuven, Dept Hepatol, Leuven, Belgium. | - |
local.publisher.place | HOBOKEN | - |
local.type.refereed | Refereed | - |
local.type.specified | Review | - |
dc.identifier.doi | 10.1111/ajt.14923 | - |
dc.identifier.isi | 000451112200022 | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2019 | - |
item.accessRights | Restricted Access | - |
item.fullcitation | Minnee, R. C.; FIEUWS, Steffen; Jochmans, I.; Aerts, R.; Barriga, M. Sainz; Debaveye, Y.; Maertens, J.; Vandenberghe, P.; Laleman, W.; van der Merwe, S.; Verslype, C.; CASSIMAN, David; Ferdinande, P.; Nevens, F.; Pirenne, J. & Monbaliu, D. (2018) Improved survival after LTx-associated acute GVHD with mAb therapy targeting IL2RAb and soluble TNFAb: Single-center experience and systematic review. In: AMERICAN JOURNAL OF TRANSPLANTATION, 18(12), p. 3007-3020. | - |
item.contributor | Minnee, R. C. | - |
item.contributor | FIEUWS, Steffen | - |
item.contributor | Jochmans, I. | - |
item.contributor | Aerts, R. | - |
item.contributor | Barriga, M. Sainz | - |
item.contributor | Debaveye, Y. | - |
item.contributor | Maertens, J. | - |
item.contributor | Vandenberghe, P. | - |
item.contributor | Laleman, W. | - |
item.contributor | van der Merwe, S. | - |
item.contributor | Verslype, C. | - |
item.contributor | CASSIMAN, David | - |
item.contributor | Ferdinande, P. | - |
item.contributor | Nevens, F. | - |
item.contributor | Pirenne, J. | - |
item.contributor | Monbaliu, D. | - |
crisitem.journal.issn | 1600-6135 | - |
crisitem.journal.eissn | 1600-6143 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
minnee 1.pdf Restricted Access | Published version | 648.12 kB | Adobe PDF | View/Open Request a copy |
SCOPUSTM
Citations
1
checked on Sep 2, 2020
WEB OF SCIENCETM
Citations
2
checked on Sep 28, 2024
Page view(s)
122
checked on Sep 7, 2022
Download(s)
92
checked on Sep 7, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.