Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/28895
Full metadata record
DC FieldValueLanguage
dc.contributor.authorBOVE, Hannelore-
dc.contributor.authorSteuwe, Christian-
dc.contributor.authorSAENEN, Nelly-
dc.contributor.authorRASKING, Leen-
dc.contributor.authorNAWROT, Tim-
dc.contributor.authorRoeffaers, Maarten-
dc.contributor.authorAMELOOT, Marcel-
dc.date.accessioned2019-08-06T15:16:26Z-
dc.date.available2019-08-06T15:16:26Z-
dc.date.issued2018-
dc.identifier.citationPopp, J Tuchin, VV Pavone, FS (Ed.). BIOPHOTONICS: PHOTONIC SOLUTIONS FOR BETTER HEALTH CARE VI, SPIE-INT SOC OPTICAL ENGINEERING, (Art N° UNSP 106852C)-
dc.identifier.isbn9781510618978-
dc.identifier.issn0277-786X-
dc.identifier.urihttp://hdl.handle.net/1942/28895-
dc.description.abstractWorldwide, outdoor air pollution is responsible for 4.2 million premature deaths per year. Both chronic and acute exposure to particulate matter air pollution is a risk factor for heart and lung diseases. One of the atmospheric pollutant particles is represented by soot or carbonaceous particles (CPs), which are produced during the incomplete combustion of fuels. To evaluate human CP exposure, a direct and label-free approach for detecting such particles in body fluids and tissues was still lacking. We present a novel technique to finally close the diagnostic gap. We report for the first time white-light generation by CPs under femtosecond pulsed near-infrared light illumination in aqueous environments and demonstrate the potential of this approach in biomedical and diagnostic context. In fact, it was shown that urinary carbon loading can serve as an exposure matrix to carbon-based air pollution, reflecting the passage of soot particles from circulation into urine. The novel method is straightforward, fast and flexible without the need of sample pretreatment. Moreover, the technique offers several other advantages such as inherent 3D sectioning and high imaging depths making it possible to screen at the cellular and tissue level. In conclusion, this novel diagnostic technique allows to quantify exposure at the personal level including different scenarios like occupational exposure, smog, forest fires, etc.. Additionally, this approach paves the way to unravel the complexity of soot-related health effects.-
dc.description.sponsorshipThis research was supported by the Interuniversity Attraction Poles Program (P7/05) initiated by the Belgian Science Policy Office. H.B. acknowledges funding from Research Foundation Flanders (Fonds Wetenschappelijk Onderzoek, FWO) for a doctoral fellowship: 11ZB115N. C.S. is supported by a postdoctoral FWO fellowship: 12R6315N. The authors also thank FWO for the research grants G082113 and G082317. M.R. acknowledges financial support from the KU Leuven Research Fund (C14/15/053, OT/12/059). M.A. thanks the Province of Limburg (Belgium) for the financial support within the tUL IMPULS FASE II program, allowing for the upgrading of the laser source used in this work. The COGNAC study received support from the European Research Council ERC-2012-StG. 310898. H.B. gratefully acknowledges the assistance of Mrs. P. Bex and Mr. J. Janssen.-
dc.language.isoen-
dc.publisherSPIE-INT SOC OPTICAL ENGINEERING-
dc.relation.ispartofseriesProceedings of SPIE-
dc.subject.othersoot particles; white light detection; two-photon microscopy; diagnostics; air pollution; human lung cells; urine-
dc.titleWhite-light from soot: closing the gap in the diagnostic market-
dc.typeProceedings Paper-
local.bibliographicCitation.authorsPopp, J Tuchin, VV Pavone, FS-
local.bibliographicCitation.conferencedateAPR 23-26, 2018-
local.bibliographicCitation.conferencenameConference on Biophotonics - Photonic Solutions for Better Health Care VI-
local.bibliographicCitation.conferenceplaceStrasbourg, FRANCE-
dc.identifier.volume10685-
local.format.pages8-
local.bibliographicCitation.jcatC1-
dc.description.notes[Bove, Hannelore; Rasking, Leentje; Ameloot, Marcel] Hasselt Univ, Biomed Res Inst, Diepenbeek, Belgium. [Bove, Hannelore; Steuwe, Christian; Roeffaers, Maarten] Katholieke Univ Leuven, Ctr Surface Chem & Catalysis, Leuven, Belgium. [Saenen, Nelly; Nawrot, Tim S.] Hasselt Univ, Ctr Environm Sci, Diepenbeek, Belgium. [Nawrot, Tim S.] Katholieke Univ Leuven, Dept Publ Hlth & Primary Care, Leuven, Belgium.-
local.publisher.placeBELLINGHAM-
local.type.refereedRefereed-
local.type.specifiedProceedings Paper-
local.bibliographicCitation.artnrUNSP 106852C-
dc.identifier.doi10.1117/12.2306392-
dc.identifier.isi000454327100039-
local.bibliographicCitation.btitleBIOPHOTONICS: PHOTONIC SOLUTIONS FOR BETTER HEALTH CARE VI-
item.fulltextNo Fulltext-
item.accessRightsClosed Access-
item.contributorBOVE, Hannelore-
item.contributorSteuwe, Christian-
item.contributorRASKING, Leen-
item.contributorRoeffaers, Maarten-
item.contributorSAENEN, Nelly-
item.contributorAMELOOT, Marcel-
item.contributorNAWROT, Tim-
item.fullcitationBOVE, Hannelore; Steuwe, Christian; SAENEN, Nelly; RASKING, Leen; NAWROT, Tim; Roeffaers, Maarten & AMELOOT, Marcel (2018) White-light from soot: closing the gap in the diagnostic market. In: Popp, J Tuchin, VV Pavone, FS (Ed.). BIOPHOTONICS: PHOTONIC SOLUTIONS FOR BETTER HEALTH CARE VI, SPIE-INT SOC OPTICAL ENGINEERING, (Art N° UNSP 106852C).-
item.validationecoom 2020-
Appears in Collections:Research publications
Show simple item record

Page view(s)

112
checked on Jun 17, 2022

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.