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http://hdl.handle.net/1942/28962
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DC Field | Value | Language |
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dc.contributor.author | Levin, Oron | - |
dc.contributor.author | Weerasekera, Akila | - |
dc.contributor.author | King, Bradley | - |
dc.contributor.author | Heise, Kirstin F. | - |
dc.contributor.author | Sima, Diana M. | - |
dc.contributor.author | Chalavi, Sima | - |
dc.contributor.author | Maes, Celine | - |
dc.contributor.author | Peeters, Ronald | - |
dc.contributor.author | Sunaert, Stefan | - |
dc.contributor.author | CUYPERS, Koen | - |
dc.contributor.author | Van Huffel, Sabine | - |
dc.contributor.author | Mantini, Dante | - |
dc.contributor.author | Himmelreich, Uwe | - |
dc.contributor.author | Swinnen, Stephan P. | - |
dc.date.accessioned | 2019-08-13T14:04:05Z | - |
dc.date.available | 2019-08-13T14:04:05Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | NEUROIMAGE, 202 (Art N° 116050) | - |
dc.identifier.issn | 1053-8119 | - |
dc.identifier.uri | http://hdl.handle.net/1942/28962 | - |
dc.description.abstract | Aging is associated with gradual alterations in the neurochemical characteristics of the brain, which can be assessed in-vivo with proton-magnetic resonance spectroscopy (1H-MRS). However, the impact of these age-related neurochemical changes on functional motor behavior is still poorly understood. Here, we address this knowledge gap and specifically focus on the neurochemical integrity of the left sensorimotor cortex (SM1) and the occipital lobe (OCC), as both regions are main nodes of the visuomotor network underlying bimanual control. 1H-MRS data and performance on a set of bimanual tasks were collected from a lifespan (20–75 years) sample of 86 healthy adults. Results indicated that aging was accompanied by decreased levels of N-acetylaspartate (NAA), glutamate-glutamine (Glx), creatine + phosphocreatine (Cr) and myo-inositol (mI) in both regions, and decreased Choline (Cho) in the OCC region. Lower NAA and Glx levels in the SM1 and lower NAA levels in the OCC were related to poorer performance on a visuomotor bimanual coordination task, suggesting that NAA could serve as a potential biomarker for the integrity of the motor system supporting bimanual control. In addition, lower NAA, Glx, and mI levels in the SM1 were found to be correlates of poorer dexterous performance on a bimanual dexterity task. These findings highlight the role for 1H-MRS to study neurochemical correlates of motor performance across the adult lifespan. | - |
dc.description.sponsorship | This work was supported by the KU Leuven Special Research Fund (grant C16/15/070), the Research Foundation – Flanders (FWO; G.089818N), the Excellence of Science grant (EOS, 30446199, MEMODYN), and the Francqui Foundation awarded to SPS and coworkers. AW and UH acknowledge financial support by the EC-FP7 MC ITN ’TRANSACT’ 2012 (No. 316679) and the KU Leuven program financing ‘IMIR’ (PF10/017). BRK acknowledges financial support by European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement (No. 703490) and a postdoctoral fellowship from the Research Foundation-Flanders (FWO; No 132635). The authors wish to thank Joren Bosman and Jeroen Buvé for assistance with data processing. | - |
dc.language.iso | en | - |
dc.publisher | ACADEMIC PRESS INC ELSEVIER SCIENCE | - |
dc.rights | 2019 Elsevier Inc. All rights reserved. | - |
dc.subject.other | Aging; Coordination; Magnetic resonance spectroscopy; Motor control; Neurometabolites | - |
dc.title | Sensorimotor cortex neurometabolite levels as correlate of motorperformance in normal aging: evidence from a 1H-MRS study | - |
dc.type | Journal Contribution | - |
dc.identifier.volume | 202 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Levin, O (reprint author), Katholieke Univ Leuven, Dept Movement Sci, Movement Control & Neuroplastic Res Grp, Tervuurse Vest 101, B-3001 Leuven, Belgium. oron.levin@kuleuven.be | - |
local.publisher.place | 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 116050 | - |
local.relation.h2020 | 703490 | - |
dc.source.type | Article | - |
dc.identifier.doi | 10.1016/j.neuroimage.2019.116050 | - |
dc.identifier.isi | WOS:000491861000089 | - |
dc.identifier.eissn | - | |
local.provider.type | Web of Science | - |
item.fulltext | With Fulltext | - |
item.contributor | Levin, Oron | - |
item.contributor | Weerasekera, Akila | - |
item.contributor | King, Bradley | - |
item.contributor | Heise, Kirstin F. | - |
item.contributor | Sima, Diana M. | - |
item.contributor | Chalavi, Sima | - |
item.contributor | Maes, Celine | - |
item.contributor | Peeters, Ronald | - |
item.contributor | Sunaert, Stefan | - |
item.contributor | CUYPERS, Koen | - |
item.contributor | Van Huffel, Sabine | - |
item.contributor | Mantini, Dante | - |
item.contributor | Himmelreich, Uwe | - |
item.contributor | Swinnen, Stephan P. | - |
item.fullcitation | Levin, Oron; Weerasekera, Akila; King, Bradley; Heise, Kirstin F.; Sima, Diana M.; Chalavi, Sima; Maes, Celine; Peeters, Ronald; Sunaert, Stefan; CUYPERS, Koen; Van Huffel, Sabine; Mantini, Dante; Himmelreich, Uwe & Swinnen, Stephan P. (2019) Sensorimotor cortex neurometabolite levels as correlate of motorperformance in normal aging: evidence from a 1H-MRS study. In: NEUROIMAGE, 202 (Art N° 116050). | - |
item.validation | ecoom 2020 | - |
item.accessRights | Restricted Access | - |
crisitem.journal.issn | 1053-8119 | - |
crisitem.journal.eissn | 1095-9572 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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Levin et al. Neuroimage (2019).pdf Restricted Access | Published version | 1.43 MB | Adobe PDF | View/Open Request a copy |
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