Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/29019
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Driessen, Johanna H. M. | - |
dc.contributor.author | de Vries, Frank | - |
dc.contributor.author | van Onzenoort, Hein A. W. | - |
dc.contributor.author | Schram, Miranda T. | - |
dc.contributor.author | VAN DER KALLEN, Carla | - |
dc.contributor.author | Reesink, Koen D. | - |
dc.contributor.author | Sep, Simone | - |
dc.contributor.author | Stehouwer, Coen D. A. | - |
dc.contributor.author | Schaper, Nicolaas | - |
dc.contributor.author | Kroon, A. A. | - |
dc.contributor.author | Schalkwijk, Casper | - |
dc.contributor.author | VAN DEN BERGH, Joop | - |
dc.contributor.author | Henry, Ronald M. A. | - |
dc.date.accessioned | 2019-08-22T11:56:04Z | - |
dc.date.available | 2019-08-22T11:56:04Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | JOURNAL OF HYPERTENSION, 37(2), p. 365-371 | - |
dc.identifier.issn | 0263-6352 | - |
dc.identifier.uri | http://hdl.handle.net/1942/29019 | - |
dc.description.abstract | Introduction: Type 2 diabetes (T2D) is associated with cardiovascular disease complications such as myocardial infarction and stroke. These complications are at least partially the consequence of diabetes-associated increased arterial stiffness. Metformin, a first choice oral glucose-lowering drug, has been associated with potential cardio-protective effects. However, there are no data on the association between real-life metformin use and arterial stiffness. The objective of the current study is to investigate in a population-based sample of individuals with T2D the association between metformin use and aortic stiffness (i.e. carotid-femoral pulse wave velocity, cfPWV) and carotid stiffness [i.e. carotid distensibility coefficient and Young's elastic modulus (YEM)]. Methods: We used data from The Maastricht Study, an ongoing observational prospective population-based cohort study (current N = 3451). All participants with T2D, based on pharmacy records (N = 672, 31.3% women, mean age 62.6 perpendicular to 7.7), were included in the current study. Linear regression analyses were used to study the association between current metformin use and cfPWV, distensibility coefficient and YEM, as compared with no metformin use. Furthermore, metformin use was stratified by cumulative dose (in grams), continuous duration of use (in days), average daily dose (in grams) and time since first prescription (in years). Regression coefficients of distensibility coefficient were multiplied by -1, consequently, for all arterial stiffness indices, a positive regression coefficient signifies increasing arterial stiffness. Results: Linear regression showed that neither current metformin use was associated with cfPWV [adjusted B: -0.04 (-0.11 to 0.02)] nor metformin use was as stratified by cumulative dose, by continuous duration of use, by average daily dose or by time since first prescription. Metformin use was statistically significantly associated with higher carotid stiffness as assessed by distensibility coefficient [0.12 (0.01 to 0.23)], but not with YEM [0.10 (-0.03 to 0.22)]. However, there was no consistent pattern with the different stratifications of metformin use when further investigating the association with distensibility coefficient. Conclusion: We showed that there is no significant association between current metformin use and aortic stiffness, regardless of how metformin use in itself was defined. In addition, metformin use was not associated with a lower carotid stiffness. The present results showed no beneficial effect of metformin use, dosage or duration on arterial stiffness in middle-aged patients with T2D. Alternatively, metformin may exerts its cardio-protective effects via other pathways. | - |
dc.description.sponsorship | The current study was supported by the European Regional Development Fund via OP-Zuid, the Province of Limburg, the Dutch Ministry of Economic Affairs (grant 31O.041), Stichting De Weijerhorst (Maastricht, the Netherlands), the Pearl String Initiative Diabetes (Amsterdam, the Netherlands), the Cardiovascular Center (CVC, Maastricht, the Netherlands), Cardiovascular Research Institute Maastricht (CARIM, Maastricht, the Netherlands), School for Public Health and Primary Care (CAPHRI, Maastricht, the Netherlands), School for Nutrition, Toxicology and Metabolism (NUTRIM, Maastricht, the Netherlands), Stichting Annadal (Maastricht, the Netherlands), Health Foundation Limburg (Maastricht, the Netherlands) and by unrestricted grants from Janssen-Cilag B.V. (Tilburg, the Netherlands), Novo Nordisk Farma B.V. (Alphen aan den Rijn, the Netherlands) and Sanofi-Aventis Netherlands B.V. (Gouda, the Netherlands). | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.rights | 2019 Wolters Kluwer Health, Inc. All rights reserved. | - |
dc.subject.other | carotid artery; distensibility; metformin use; pulse wave velocity | - |
dc.subject.other | carotid artery; distensibility; metformin use; pulse wave velocity | - |
dc.title | Metformin use in type 2 diabetic patients is not associated with lower arterial stiffness: the Maastricht Study | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 371 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 365 | - |
dc.identifier.volume | 37 | - |
local.format.pages | 7 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Driessen, Johanna H. M.; de Vries, Frank] Maastricht Univ, CAPHRI Sch Publ Hlth & Primary Care, Maastricht, Netherlands. [Driessen, Johanna H. M.] Maastricht Univ, NUTRIM Sch Nutr & Translat Res Metab, Maastricht, Netherlands. [Driessen, Johanna H. M.; de Vries, Frank; van Onzenoort, Hein A. W.] Maastricht Univ, Med Ctr, Dept Clin Pharm & Toxicol, Maastricht, Netherlands. [Driessen, Johanna H. M.; de Vries, Frank] Utrecht Inst Pharmaceut Sci, Div Pharmacoepidemiol & Clin Pharmacol, Utrecht, Netherlands. [de Vries, Frank] Southampton Gen Hosp, MRC Epidemiol Lifecourse Unit, Southampton, Hants, England. [van Onzenoort, Hein A. W.] Radboud Univ Nijmegen, Med Ctr, Dept Pharm, Nijmegen, Netherlands. [Schram, Miranda T.; van der Kallen, Carla; Sep, Simone; Stehouwer, Coen D. A.; Schaper, Nicolaas; Kroon, A. A.; Schalkwijk, Casper; Henry, Ronald M. A.] Maastricht Univ, Med Ctr, Dept Internal Med, P Debyelaan 25,POB 5800, NL-6202AZ Maastricht, Netherlands. [Schram, Miranda T.; van der Kallen, Carla; Sep, Simone; Stehouwer, Coen D. A.; Schaper, Nicolaas; Kroon, A. A.; Schalkwijk, Casper; Henry, Ronald M. A.] Maastricht Univ, Med Ctr, Cardiovasc Res Inst Maastricht, Maastricht, Netherlands. [Reesink, Koen D.] Maastricht Univ, Med Ctr, Cardiovasc Res Inst Maastricht, Dept Biomed Engn, Maastricht, Netherlands. [Reesink, Koen D.; Henry, Ronald M. A.] Maastricht Univ, Med Ctr, Heart & Vasc Ctr, Maastricht, Netherlands. [van den Bergh, Joop P. W.] VieCuri Med Ctr, Dept Internal Med, Venlo, Netherlands. [van den Bergh, Joop P. W.] Hasselt Univ, Biomed Res Ctr, Hasselt, Belgium. [van den Bergh, Joop P. W.] Maastricht Univ, Med Ctr, Dept Internal Med, Subdiv Rheumatol, Maastricht, Netherlands. | - |
local.publisher.place | PHILADELPHIA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.class | dsPublValOverrule/author_version_not_expected | - |
dc.identifier.doi | 10.1097/HJH.0000000000001892 | - |
dc.identifier.isi | 000467336700018 | - |
item.fullcitation | Driessen, Johanna H. M.; de Vries, Frank; van Onzenoort, Hein A. W.; Schram, Miranda T.; VAN DER KALLEN, Carla; Reesink, Koen D.; Sep, Simone; Stehouwer, Coen D. A.; Schaper, Nicolaas; Kroon, A. A.; Schalkwijk, Casper; VAN DEN BERGH, Joop & Henry, Ronald M. A. (2019) Metformin use in type 2 diabetic patients is not associated with lower arterial stiffness: the Maastricht Study. In: JOURNAL OF HYPERTENSION, 37(2), p. 365-371. | - |
item.validation | ecoom 2020 | - |
item.contributor | Driessen, Johanna H. M. | - |
item.contributor | de Vries, Frank | - |
item.contributor | van Onzenoort, Hein A. W. | - |
item.contributor | Schram, Miranda T. | - |
item.contributor | VAN DER KALLEN, Carla | - |
item.contributor | Reesink, Koen D. | - |
item.contributor | Sep, Simone | - |
item.contributor | Stehouwer, Coen D. A. | - |
item.contributor | Schaper, Nicolaas | - |
item.contributor | Kroon, A. A. | - |
item.contributor | Schalkwijk, Casper | - |
item.contributor | VAN DEN BERGH, Joop | - |
item.contributor | Henry, Ronald M. A. | - |
item.fulltext | With Fulltext | - |
item.accessRights | Restricted Access | - |
crisitem.journal.issn | 0263-6352 | - |
crisitem.journal.eissn | 1473-5598 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
00004872-201902000-00019.pdf Restricted Access | Published version | 164.26 kB | Adobe PDF | View/Open Request a copy |
SCOPUSTM
Citations
2
checked on Sep 5, 2020
WEB OF SCIENCETM
Citations
8
checked on Jul 18, 2024
Page view(s)
76
checked on Sep 7, 2022
Download(s)
46
checked on Sep 7, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.