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http://hdl.handle.net/1942/2903
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DC Field | Value | Language |
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dc.contributor.author | Jorens, PG | - |
dc.contributor.author | VANDER BORGHT, Ann | - |
dc.contributor.author | Ceulemans, B | - |
dc.contributor.author | Van Bever, HP | - |
dc.contributor.author | Bossaert, LL | - |
dc.contributor.author | Ieven, M | - |
dc.contributor.author | Goossens, H | - |
dc.contributor.author | Parizel, PM | - |
dc.contributor.author | Van Dijk, H | - |
dc.contributor.author | RAUS, Jef | - |
dc.contributor.author | STINISSEN, Piet | - |
dc.date.accessioned | 2007-11-20T12:44:06Z | - |
dc.date.available | 2007-11-20T12:44:06Z | - |
dc.date.issued | 2000 | - |
dc.identifier.citation | NEUROLOGY, 54(7). p. 1433-1441 | - |
dc.identifier.issn | 0028-3878 | - |
dc.identifier.uri | http://hdl.handle.net/1942/2903 | - |
dc.description.abstract | Objective: After implicating Streptococcus pyogenes as causing acute disseminated encephalomyelitis (ADEM) in a child, we wanted to prove that in vivo activation of autoreactive T lymphocytes by superantigens of this Streptococcus contributed to the dramatic demyelination. Background: ADEM is a demyelinating disorder of the CNS sharing many similarities with MS. Demyelination in MS is considered to be the result of an autoimmune process mediated by autoreactive T lymphocytes with specificity for myelin antigens. Methods: Phenotypic analysis and proliferation assays on blood monocytes, as well as isolation of myelin basic protein (MBP)-reactive T-cell lines/clones; and TCR repertorium analysis by PCR-ELISA and cytokine production. Results: 1) The blood T-cell receptor (TCR) repertoire was compatible with in vivo expansion induced by S. pyogenes exotoxins, 2) TCR expression analysis indicated clonal expansion of CD8(+) MBP-reactive T cells, suggesting in vivo activation. MBP-reactive T cells showed crossreactivity to S. pyogenes supernatant and exotoxins. 3) Cytokine mRNA quantification of the mononuclear cells revealed a Th2-biased profile. Conclusion: In vivo exposure to S. pyogenes may have induced activation of pathogenic myelin reactive T cells, contributing to the dramatic inflammatory demyelination. | - |
dc.language.iso | en | - |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | - |
dc.subject.other | acute disseminated encephalomyelitis autoimmune diseases; T lymphocytes; streptococcus pyogenes; exotoxins; superantigens; MS-demyelination; myelin basic proteins; experimental autoimmune encephalomyelitis | - |
dc.title | Encephalomyelitis-associated antimyelin autoreactivity induced by streptococcal exotoxins | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 1441 | - |
dc.identifier.issue | 7 | - |
dc.identifier.spage | 1433 | - |
dc.identifier.volume | 54 | - |
local.format.pages | 9 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Univ Antwerp Hosp, Dept Intens Care Med, B-2650 Edegem, Belgium. Univ Antwerp Hosp, Dept Neurol, B-2650 Edegem, Belgium. Univ Antwerp Hosp, Dept Pediat, B-2650 Edegem, Belgium. Univ Antwerp Hosp, Dept Microbiol, B-2650 Edegem, Belgium. Univ Antwerp Hosp, Dept Radiol, B-2650 Edegem, Belgium. Univ Utrecht, Acad Ziekenhuis, Dept Microbiol, Utrecht, Netherlands. Limburgs Univ Ctr, Biomed Onderzoeksinst DWI, Diepenbeek, Belgium.Jorens, PG, Univ Antwerp Hosp, Dept Intens Care Med, Wilrjkstr 10, B-2650 Edegem, Belgium. | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.bibliographicCitation.oldjcat | A1 | - |
dc.identifier.isi | 000086460900008 | - |
item.validation | ecoom 2001 | - |
item.accessRights | Closed Access | - |
item.fullcitation | Jorens, PG; VANDER BORGHT, Ann; Ceulemans, B; Van Bever, HP; Bossaert, LL; Ieven, M; Goossens, H; Parizel, PM; Van Dijk, H; RAUS, Jef & STINISSEN, Piet (2000) Encephalomyelitis-associated antimyelin autoreactivity induced by streptococcal exotoxins. In: NEUROLOGY, 54(7). p. 1433-1441. | - |
item.fulltext | No Fulltext | - |
item.contributor | Jorens, PG | - |
item.contributor | VANDER BORGHT, Ann | - |
item.contributor | Ceulemans, B | - |
item.contributor | Van Bever, HP | - |
item.contributor | Bossaert, LL | - |
item.contributor | Ieven, M | - |
item.contributor | Goossens, H | - |
item.contributor | Parizel, PM | - |
item.contributor | Van Dijk, H | - |
item.contributor | RAUS, Jef | - |
item.contributor | STINISSEN, Piet | - |
Appears in Collections: | Research publications |
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