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Title: | Current evidence for a role of epigenetic mechanisms in response to ionizing radiation in an ecotoxicological context | Authors: | HOREMANS, Nele Spurgeon, David J. Lecomte-Pradines, Catherine SAENEN, Eline Bradshaw, Clare Oughton, Deborah Rasnaca, Ilze Kamstra, Jorke H. Adam-Guillermin, Christelle |
Issue Date: | 2019 | Publisher: | ELSEVIER SCI LTD | Source: | ENVIRONMENTAL POLLUTION, 251, p. 469-483 | Abstract: | The issue of potential long-term or hereditary effects for both humans and wildlife exposed to low doses (or dose rates) of ionising radiation is a major concern. Chronic exposure to ionising radiation, defined as an exposure over a large fraction of the organism's lifespan or even over several generations, can possibly have consequences in the progeny. Recent work has begun to show that epigenetics plays an important role in adaptation of organisms challenged to environmental stimulae. Changes to so-called epigenetic marks such as histone modifications, DNA methylation and non-coding RNAs result in altered transcriptomes and proteomes, without directly changing the DNA sequence. Moreover, some of these environmentally-induced epigenetic changes tend to persist over generations, and thus, epigenetic modifications are regarded as the conduits for environmental influence on the genome. Here, we review the current knowledge of possible involvement of epigenetics in the cascade of responses resulting from environmental exposure to ionising radiation. In addition, from a comparison of lab and field obtained data, we investigate evidence on radiation-induced changes in the epigenome and in particular the total or locus specific levels of DNA methylation. The challenges for future research and possible use of changes as an early warning (biomarker) of radiosensitivity and individual exposure is discussed. Such a biomarker could be used to detect and better understand the mechanisms of toxic action and inter/intra-species susceptibility to radiation within an environmental risk assessment and management context. (C) 2019 Elsevier Ltd. All rights reserved. | Notes: | [Horemans, Nele; Saenen, Eline] Belgian Nucl Res Ctr, Boeretang 200, B-2400 Mol, Belgium. [Horemans, Nele] Univ Hasselt, Ctr Environm Res, B-3590 Diepenbeek, Belgium. [Spurgeon, David J.; Rasnaca, Ilze] Ctr Ecol & Hydrol, MacLean Bldg,Benson Lane, Wallingford OX10 8BB, Oxon, England. [Lecomte-Pradines, Catherine] Cadarache, PSE ENV SRTE LECO, Inst Radioprotect & Surete Nucl, St Paul Les Durance, France. [Bradshaw, Clare] Stockholm Univ, Dept Ecol Environm & Plant Sci, S-10691 Stockholm, Sweden. [Oughton, Deborah] Norwegian Univ Life Sci, Ctr Environm Radioact CERAD, N-1430 As, Norway. [Kamstra, Jorke H.] Univ Utrecht, Inst Risk Assessment Sci, Fac Vet Med, Utrecht, Netherlands. [Adam-Guillermin, Christelle] Cadarache, PSE SANTE, Inst Radioprotect & Surete Nucl, St Paul Les Durance, France. | Keywords: | Epigenetic marks; Radioecology; DNA methylation; Gamma radiation; Chronic exposure; Multi-transgenerational; Wildlife; Chernobyl; Chernobyl; Fukushima; Nuclear accidents;Epigenetic marks; Radioecology; DNA methylation; Gamma radiation; Chronic exposure; Multi-transgenerational; Wildlife; Chernobyl; Chernobyl; Fukushima; Nuclear accidents | Document URI: | http://hdl.handle.net/1942/29064 | ISSN: | 0269-7491 | e-ISSN: | 1873-6424 | DOI: | 10.1016/j.envpol.2019.04.125 | ISI #: | 000474329700052 | Rights: | 2019 Elsevier Ltd. All rights reserved. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2020 |
Appears in Collections: | Research publications |
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