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http://hdl.handle.net/1942/29072
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DC Field | Value | Language |
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dc.contributor.author | LA GAMBA, Fabiola | - |
dc.contributor.author | JACOBS, Tom | - |
dc.contributor.author | GEYS, Helena | - |
dc.contributor.author | Jaki, Thomas | - |
dc.contributor.author | SERROYEN, Jan | - |
dc.contributor.author | Ursino, Moreno | - |
dc.contributor.author | Russu, Alberto | - |
dc.contributor.author | FAES, Christel | - |
dc.date.accessioned | 2019-08-30T09:35:05Z | - |
dc.date.available | 2019-08-30T09:35:05Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | PHARMACEUTICAL STATISTICS, 18 (4), p. 486-506 | - |
dc.identifier.issn | 1539-1604 | - |
dc.identifier.uri | http://hdl.handle.net/1942/29072 | - |
dc.description.abstract | The present manuscript aims to discuss the implications of sequential knowledge integration of small preclinical trials in a Bayesian pharmacokinetic and pharmacodynamic (PK-PD) framework. While, at first sight, a Bayesian PK-PD framework seems to be a natural framework to allow for sequential knowledge integration, the scope of this paper is to highlight some often-overlooked challenges while at the same time providing some guidances in the many and overwhelming choices that need to be made. Challenges as well as opportunities will be discussed that are related to the impact of (1) the prior specification, (2) the choice of random effects, (3) the type of sequential integration method. In addition, it will be shown how the success of a sequential integration strategy is highly dependent on a carefully chosen experimental design when small trials are analyzed. | - |
dc.description.sponsorship | European Union's Horizon 2020 research and innovation programme, Grant/Award Number: 633567; IAP Research Network P7/06 of the Belgian State (Belgian Science Policy); French National Cancer Institute (INCa), Grant/Award Number: INCA 9539 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.rights | 2019 John Wiley & Sons, Ltd | - |
dc.subject.other | Bayesian inference; nonlinear hierarchical models; pharmacodynamics; pharmacokinetics; recursive; sequential | - |
dc.subject.other | Bayesian inference; nonlinear hierarchical models; pharmacodynamics; pharmacokinetics;recursive; sequential | - |
dc.title | Bayesian sequential integration within a preclinical pharmacokinetic and pharmacodynamic modeling framework: Lessons learned | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 506 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 486 | - |
dc.identifier.volume | 18 | - |
local.format.pages | 21 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [La Gamba, Fabiola; Jacobs, Tom; Geys, Helena; Serroyen, Jan; Russu, Alberto] Janssen Res & Dev, Dept Quantitat Sci, Beerse, Belgium. [La Gamba, Fabiola; Geys, Helena; Faes, Christel] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, Diepenbeek, Belgium. [Jaki, Thomas] Univ Lancaster, Dept Math & Stat, Lancaster, England. [Ursino, Moreno] Univ Paris Diderot, Univ Paris Descartes, Sorbonne Univ, Ctr Rech Cordeliers,INSERM,USPC, Paris, France. | - |
local.publisher.place | HOBOKEN | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.relation.h2020 | 633567 | - |
dc.identifier.doi | 10.1002/pst.1941 | - |
dc.identifier.isi | 000474896500008 | - |
item.fulltext | With Fulltext | - |
item.accessRights | Restricted Access | - |
item.fullcitation | LA GAMBA, Fabiola; JACOBS, Tom; GEYS, Helena; Jaki, Thomas; SERROYEN, Jan; Ursino, Moreno; Russu, Alberto & FAES, Christel (2019) Bayesian sequential integration within a preclinical pharmacokinetic and pharmacodynamic modeling framework: Lessons learned. In: PHARMACEUTICAL STATISTICS, 18 (4), p. 486-506. | - |
item.validation | ecoom 2020 | - |
item.contributor | LA GAMBA, Fabiola | - |
item.contributor | JACOBS, Tom | - |
item.contributor | GEYS, Helena | - |
item.contributor | Jaki, Thomas | - |
item.contributor | SERROYEN, Jan | - |
item.contributor | Ursino, Moreno | - |
item.contributor | Russu, Alberto | - |
item.contributor | FAES, Christel | - |
crisitem.journal.issn | 1539-1604 | - |
crisitem.journal.eissn | 1539-1612 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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la gamba 1.pdf Restricted Access | Published version | 15.47 MB | Adobe PDF | View/Open Request a copy |
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