Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/29073
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dc.contributor.authorMaron, Eva-
dc.contributor.authorSwisher, Jordan H.-
dc.contributor.authorHAVEN, Joris-
dc.contributor.authorMeyer, Tara Y.-
dc.contributor.authorJUNKERS, Tanja-
dc.contributor.authorBoerner, Hans G.-
dc.date.accessioned2019-08-30T09:42:49Z-
dc.date.available2019-08-30T09:42:49Z-
dc.date.issued2019-
dc.identifier.citationANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 58 (31), p. 10747-10751-
dc.identifier.issn1433-7851-
dc.identifier.urihttp://hdl.handle.net/1942/29073-
dc.description.abstractFunctional precision polymers based on monodisperse oligo(N-substituted acrylamide)s and oligo(2-substituted-alpha-hydroxy acid)s have been synthesized. The discrete sequences originate from a direct translation of side-chain functionality sequences of a peptide with well-studied properties. The peptide was previously selected to solubilize the photosensitizer meta-tetra(hydroxyphenyl)chlorin. The resulting peptidomimetic formulation additives preserve the drug solubilization and release characteristics of the parent peptide. In some cases, superior properties are obtained, reaching up to 40 % higher payloads and 27-times faster initial drug release.-
dc.description.sponsorshipH.G.B. acknowledges financial support by the European Research Council under the European Union's 7th Framework Program (FP07-13)/ERC Consolidator grant "Specifically Interacting Polymer-SIP" (ERC 305064). T.Y.M. acknowledges financial support from the National Science Foundation (CHE-1709144). Additional support for MALDI-TOF MS instrumentation was provided by a grant from the National Science Foundation (CHE-1625002). T.J. and J.J.H. are grateful for provision of the mass spectrometer through the Hercules fund Belgium. J.J.H. and T.J. thank J. Vandenbergh for contributing to the synthesis of the SUMI oligomers.-
dc.language.isoen-
dc.publisherWILEY-V C H VERLAG GMBH-
dc.rights2019 Wiley-VCH Verlag GmbH&Co. KGaA,Weinheim-
dc.subject.otherdrug deliverysystem; monodisperse polymers; peptide PEG conjugates; precision polymers; sequencedesign-
dc.subject.otherdrug delivery system; monodisperse polymers; peptide PEG conjugates; precision polymers; sequence design-
dc.titleLearning from Peptides To Access Functional Precision Polymer Sequences-
dc.typeJournal Contribution-
dc.identifier.epage10751-
dc.identifier.issue31-
dc.identifier.spage10747-
dc.identifier.volume58-
local.format.pages5-
local.bibliographicCitation.jcatA1-
dc.description.notes[Maron, Eva; Boerner, Hans G.] Humboldt Univ, Dept Chem, Brook Taylor Str 2, D-12489 Berlin, Germany. [Swisher, Jordan H.; Meyer, Tara Y.] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA. [Haven, Joris J.; Junkers, Tanja] Monash Univ, Sch Chem, Polymer React Design Grp, 19 Rainforest Walk, Clayton, Vic 3800, Australia. [Junkers, Tanja] Hasselt Univ, Inst Mat Res, Martelarenlaan 42, B-3500 Hasselt, Belgium.-
local.publisher.placeWEINHEIM-
local.type.refereedRefereed-
local.type.specifiedArticle-
dc.identifier.doi10.1002/anie.201902217-
dc.identifier.isi000474091700001-
item.fulltextWith Fulltext-
item.contributorMaron, Eva-
item.contributorSwisher, Jordan H.-
item.contributorHAVEN, Joris-
item.contributorMeyer, Tara Y.-
item.contributorJUNKERS, Tanja-
item.contributorBoerner, Hans G.-
item.fullcitationMaron, Eva; Swisher, Jordan H.; HAVEN, Joris; Meyer, Tara Y.; JUNKERS, Tanja & Boerner, Hans G. (2019) Learning from Peptides To Access Functional Precision Polymer Sequences. In: ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 58 (31), p. 10747-10751.-
item.accessRightsRestricted Access-
crisitem.journal.issn1433-7851-
crisitem.journal.eissn1521-3773-
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