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DC Field | Value | Language |
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dc.contributor.author | DERA, Rafael | - |
dc.contributor.author | DILIEN, Hanne | - |
dc.contributor.author | BILLEN, Brecht | - |
dc.contributor.author | Gagliardi, Mick | - |
dc.contributor.author | Rahimi, Nastaran | - |
dc.contributor.author | Van Den Akker, Nynke M. S. | - |
dc.contributor.author | Molin, Daniel G.M. | - |
dc.contributor.author | Grandfils, Christian | - |
dc.contributor.author | CLEIJ, Thomas | - |
dc.contributor.author | ADRIAENSENS, Peter | - |
dc.contributor.author | GUEDENS, Wanda | - |
dc.date.accessioned | 2019-09-02T14:00:07Z | - |
dc.date.available | 2019-09-02T14:00:07Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | MACROMOLECULAR BIOSCIENCE, 19(7) (Art N° 1900090) | - |
dc.identifier.issn | 1616-5187 | - |
dc.identifier.uri | http://hdl.handle.net/1942/29089 | - |
dc.description.abstract | Given the major structural role phosphodiesters play in the organism it is surprising they have not been more widely adopted as a building block in sophisticated biomimetic hydrogels and other biomaterials. The potential benefits are substantial: phosphoester-based materials show excellent compatibility with blood, cells, and a remarkable resistance to protein adsorption that may trigger a foreign-body response. In this work, a novel class of phosphodiester-based ionic hydrogels is presented which are crosslinked via a phosphodiester moiety. The material shows good compatibility with blood, supports the growth and proliferation of tissue and presents opportunities for use as a drug release matrix as shown with fluorescent model compounds. The final gel is produced via base-induced elimination from a phosphotriester precursor, which is made by the free-radical polymerization of a phosphotriester crosslinker. This crosslinker is easily synthesized via multigram one-pot procedures out of common laboratory chemicals. Via the addition of various comonomers the properties of the final gel may be tuned leading to a wide range of novel applications for this exciting class of materials. | - |
dc.description.sponsorship | R.D. and H.D. contributed equally to this work. This study is part of the Euregional Meuse-Rhine Interreg IVa project "BioMIMedics" (www.biomimedics.org).The Universities of Maastricht, Liege (Belgium), Hasselt (Belgium) and Aachen (RWTH and Fachhochschule, Germany), as well as several regional biotechnological enterprises cooperate in "BioMIMedics." We further acknowledge the financial support from the Interuniversity Attraction Poles Programme (P7/05) initiated by the Belgian Science Policy Office (BELSPO). R.D. also wishes to acknowledge Hasselt University's BOF program. The SEM image was recorded by Prof. Jan D'Haen (IMO, Hasselt University). The DMA analysis was performed by Prof.-Ing. Dietmar Auhl and Nils Leone (AMIBM, Maastricht University). the Euregional Meuse-Rhine Interreg IVa project “BioMIMedics” (www. biomimedics.org). The Universities of Maastricht, Liège (Belgium), Hasselt (Belgium) and Aachen (RWTH and Fachhochschule, Germany), as well as several regional biotechnological enterprises cooperate in “BioMIMedics.” We further acknowledge the financial support from the Interuniversity Attraction Poles Programme (P7/05) initiated by the Belgian Science Policy Office (BELSPO). R.D. also wishes to acknowledge Hasselt University’s BOF program. The SEM image was recorded by Prof. Jan D’Haen (IMO, Hasselt University). The DMA analysis was performed by Prof.-Ing. Dietmar Auhl and Nils Leone (AMIBM, Maastricht University). | - |
dc.language.iso | en | - |
dc.rights | 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim | - |
dc.subject.other | biomaterials; hemocompatibility; hydrogels; phosphodiesters | - |
dc.title | Phosphodiester Hydrogels for Cell Scaffolding and Drug Release Applications | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 7 | - |
dc.identifier.volume | 19 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | Dilien, H (reprint author), Maastricht Univ, Sensor Engn, Fac Sci & Engn, Urmonderbaan 22,Gebouw 200, NL-6167 RD Geleen, Netherlands. Hanne.dilien@maastrichtuniversity.nl | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 1900090 | - |
dc.identifier.doi | 10.1002/mabi.201900090 | - |
dc.identifier.isi | 000476756700001 | - |
item.validation | ecoom 2020 | - |
item.contributor | DERA, Rafael | - |
item.contributor | DILIEN, Hanne | - |
item.contributor | BILLEN, Brecht | - |
item.contributor | Gagliardi, Mick | - |
item.contributor | Rahimi, Nastaran | - |
item.contributor | Van Den Akker, Nynke M. S. | - |
item.contributor | Molin, Daniel G.M. | - |
item.contributor | Grandfils, Christian | - |
item.contributor | CLEIJ, Thomas | - |
item.contributor | ADRIAENSENS, Peter | - |
item.contributor | GUEDENS, Wanda | - |
item.accessRights | Restricted Access | - |
item.fullcitation | DERA, Rafael; DILIEN, Hanne; BILLEN, Brecht; Gagliardi, Mick; Rahimi, Nastaran; Van Den Akker, Nynke M. S.; Molin, Daniel G.M.; Grandfils, Christian; CLEIJ, Thomas; ADRIAENSENS, Peter & GUEDENS, Wanda (2019) Phosphodiester Hydrogels for Cell Scaffolding and Drug Release Applications. In: MACROMOLECULAR BIOSCIENCE, 19(7) (Art N° 1900090). | - |
item.fulltext | With Fulltext | - |
crisitem.journal.issn | 1616-5187 | - |
crisitem.journal.eissn | 1616-5195 | - |
Appears in Collections: | Research publications |
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Dera_et_al-2019-Macromolecular_Bioscience.pdf Restricted Access | Published version | 2.86 MB | Adobe PDF | View/Open Request a copy |
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