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http://hdl.handle.net/1942/29110Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Conte, Valeria | - |
| dc.contributor.author | BIANCHI, Anna | - |
| dc.contributor.author | Selva, Anna | - |
| dc.contributor.author | Petringa, Giada | - |
| dc.contributor.author | Cirrone, G. A. Pablo | - |
| dc.contributor.author | Parisi, Alessio | - |
| dc.contributor.author | Vanhavere, Filip | - |
| dc.contributor.author | Colautti, Paolo | - |
| dc.date.accessioned | 2019-09-06T13:48:06Z | - |
| dc.date.available | 2019-09-06T13:48:06Z | - |
| dc.date.issued | 2019 | - |
| dc.identifier.citation | Physica Medica-European Journal of Medical Physics, 64(3), p. 114-122 | - |
| dc.identifier.issn | 1120-1797 | - |
| dc.identifier.uri | http://hdl.handle.net/1942/29110 | - |
| dc.description.abstract | A new mini-TEPC with cylindrical sensitive volume of 0.9mm in diameter and height, and with external diameter of 2.7 mm, has been developed to work without gas flow. With such a mini counter we have measured the physical quality of the 62 MeV therapeutic proton beam of CATANA (Catania, Italy). Measurements were performed at six precise positions along the Spread-Out Bragg Peak (SOBP): 1.4, 19.4, 24.6, 29.0, 29.7 and 30.8 mm, corresponding to positions of clinical relevance (entrance, proximal, central, and distal-edge of the SOBP) or of high lineal energy transfer (LET) increment (distal-dose drop off). Without refilling the microdosimeter with new gas, the measurements were repeated at the same positions 4 months later, in order to study the stability of the response in sealed-mode operation. From the microdosimetric spectra the frequency-mean lineal energy yF and the dose-mean lineal energy yD were derived and compared with average LET values calculated by means of Geant4 simulations. The comparison points out, in particular, a good agreement between microdosimetric yD and the total dose-average LET_d, which is the average LET of the mixed radiation field, including the contribution by nuclear reactions. | - |
| dc.description.sponsorship | This work was supported by the Italian Institute for Nuclear Physics(INFN). The Belgian nuclear research centre SCK·CEN and HasseltUniversity provide a Phd scholarship | - |
| dc.language.iso | en | - |
| dc.publisher | ELSEVIER SCI LTD | - |
| dc.rights | 2019 Associazione Italiana di Fisica Medica. Published by Elsevier Ltd. All rights reserved | - |
| dc.subject.other | TEPC; Microdosimetry; Proton therapy; Proton RBE | - |
| dc.title | Microdosimetry at the CATANA 62 MeV proton beam with a sealed miniaturized TEPC | - |
| dc.type | Journal Contribution | - |
| dc.identifier.epage | 122 | - |
| dc.identifier.issue | 3 | - |
| dc.identifier.spage | 114 | - |
| dc.identifier.volume | 64 | - |
| local.bibliographicCitation.jcat | A1 | - |
| local.publisher.place | THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND | - |
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Acta Oncologica 2011;50:757–62. [8] Rossi HH, Zaider M. Microdosimetry and its Applications p. 21 Berlin Heidelberg, New York: Springer; 1996. [9] Agosteo S, Colautti P, Fazzi A, Moro D, Pola A. A solid state microdosimeter based on a monolithic silicon telescope. Radiat Prot Dosimetry 2006;122(1–4):382–6. [10] Rosenfeld AB. Novel detectors for silicon based microdosimetry, their concepts and applications. Nucl Instr Meth A 2016;809:156–70. [11] Guardiola C, Fleta C, Rodríguez J, Lozano M, Gómez F. Preliminarymicrodosimetric measurements with ultra-thin 3D silicon detectors of a 62 MeV proton beam. JINST 2015;10:P01008. [12] Verona C, Magrin G, Solevi P, Bandorf M, Marinelli M, Stock M, Verona Rinati G. Toward the use of single crystal diamond based detector for ion-beam therapy microdosimetry. Rad Meas 2018;110:25–31. [13] De Nardo L, Cesari V, Donà G, Magrin G, Colautti P, et al. Mini-TEPCs for radiation therapy. Rad Prot Dos 2004;108:345–52. 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Linear energy calibration of mini tissue equivalent gas-proportional counters (TEPC). Multidisciplinary Applications of Nuclear Physics with Ion Beams (ION BEAMS ’12) – AIP Conf Proc, vol. 530. 2013. p. 171–8. [20] Kase Y, Kanai T, Skama M, Tameshige Y, Himkai T, et al. Microdosimetric approach to NIRS-defined biological dose measurements for carbon-ion treatment beam. J Radiat Res 2011;52:59–68. [21] Kellerer AM, Rossi HH. The theory of dual radiation action. Curr Top Radiat Res 1972;8:85–158. [22] ICRU, ICRU Report 36: Microdosimetry (1983). [23] Loncol T, Cosgrove V, Denis JM, Gueulette J, Mazal A, et al. Radiobiological effectiveness of radiation beams with broad LET spectra: microdosimetric analysis using biological weighting functions. Rad Prot Dosim 1994;52:347–52. [24] Cirrone GAP, Cuttone G, Di Rosa F, Raffaele L, Russo G, et al. The geant4 toolkit capability in the hadron therapy field: simulation of a transport beam line. Nucl Phys B 2005;150:54–7. [25] Allison J, Amako K, Apostolakis J, Arce P, Asai M, et al. Recent developments in GEANT4. Nucl Instrum Meth A 2016;835:186–225. [26] Romano F, Cirrone GAP, Cuttone G, Di Rosa F, Mazzaglia SE, Petrovic I, Ristic Fira A, Varisano A. A Monte Carlo study for the calculation of the average linear energy transfer (LET) distributions for a clinical proton beam line and a radiobiological carbon ion beam line. Phys Med Biol 2014;59:2863–82. [27] Petringa G, Cirrone GAP, et al. Development and analysis of the track-LET, dose-LET and RBE calculations with a therapeutical proton and ion beams using Geant4 Monte Carlo code. Physica Medica 2017;42(1):9. https://doi.org/10.1016/j.ejmp.2017.09.023. [28] Cirrone GAP, et al. Clinical and research activities at the CATANA Facility of INFNLNS: from the conventional hadrontherapy to the laser-driven approach. Front. Oncol. 2017. https://doi.org/10.3389/fonc.2017.00223. [29] GUM, Guide to the expression of uncertainty in measurement, JCGM 100; 2008. [30] Pihet P, Menzel HG, Schmidt R, Beauduin M, Wambersie A. Biological weighting function for RBE specification of neutron therapy beams. Intercomparison of 9 European centres. Rad. Prot. Dosim. 1990;31(1-4):437–42. [31] Gueulette J, et al. Intestinal crypt regeneration in mice: A biological system for quality assurance in non-conventional radiation therapy. Radiother Oncol 2005;73(Suppl 2):S148–54. [32] Friedrich T, Scholz U, Elsässer T, Durante M, Scholz M. Systematic analysis of RBE and related quantities using a database of cell survival experiments with ion beam irradiation. J Radiat Res 2013;54(3):494–514. | - |
| local.type.refereed | Refereed | - |
| local.type.specified | Article | - |
| dc.source.type | Article | - |
| dc.identifier.doi | 10.1016/j.ejmp.2019.06.011 | - |
| dc.identifier.isi | WOS:000485006200016 | - |
| dc.identifier.eissn | - | |
| local.provider.type | Web of Science | - |
| item.fullcitation | Conte, Valeria; BIANCHI, Anna; Selva, Anna; Petringa, Giada; Cirrone, G. A. Pablo; Parisi, Alessio; Vanhavere, Filip & Colautti, Paolo (2019) Microdosimetry at the CATANA 62 MeV proton beam with a sealed miniaturized TEPC. In: Physica Medica-European Journal of Medical Physics, 64(3), p. 114-122. | - |
| item.accessRights | Restricted Access | - |
| item.validation | ecoom 2020 | - |
| item.contributor | Conte, Valeria | - |
| item.contributor | BIANCHI, Anna | - |
| item.contributor | Selva, Anna | - |
| item.contributor | Petringa, Giada | - |
| item.contributor | Cirrone, G. A. Pablo | - |
| item.contributor | Parisi, Alessio | - |
| item.contributor | Vanhavere, Filip | - |
| item.contributor | Colautti, Paolo | - |
| item.fulltext | With Fulltext | - |
| crisitem.journal.issn | 1120-1797 | - |
| crisitem.journal.eissn | 1724-191X | - |
| Appears in Collections: | Research publications | |
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| File | Description | Size | Format | |
|---|---|---|---|---|
| 1-s2.0-S1120179719301474-main.pdf Restricted Access | Published version | 2.1 MB | Adobe PDF | View/Open Request a copy |
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