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http://hdl.handle.net/1942/29117
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DC Field | Value | Language |
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dc.contributor.author | Kogame, Norihiro | - |
dc.contributor.author | Chichareon, Ply | - |
dc.contributor.author | De Wilder, Kenneth | - |
dc.contributor.author | Takahashi, Kuniaki | - |
dc.contributor.author | Modolo, Rodrigo | - |
dc.contributor.author | Chang, Chun Chin | - |
dc.contributor.author | Tomaniak, Mariusz | - |
dc.contributor.author | Komiyama, Hidenori | - |
dc.contributor.author | Chieffo, Alaide | - |
dc.contributor.author | Colombo, Antonio | - |
dc.contributor.author | Garg, Scot | - |
dc.contributor.author | Louvard, Yves | - |
dc.contributor.author | Juni, Peter | - |
dc.contributor.author | Steg, Philippe G. | - |
dc.contributor.author | Hamm, Christian | - |
dc.contributor.author | VRANCKX, Pascal | - |
dc.contributor.author | Valgimigli, Marco | - |
dc.contributor.author | Windecker, Stephan | - |
dc.contributor.author | Stoll, Hans-Peter | - |
dc.contributor.author | Onuma, Yoshinobu | - |
dc.contributor.author | Janssens, Luc | - |
dc.contributor.author | Serruys, Patrick W. | - |
dc.date.accessioned | 2019-09-09T09:54:18Z | - |
dc.date.available | 2019-09-09T09:54:18Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, 96 (1), p. 100-111 | - |
dc.identifier.issn | 1522-1946 | - |
dc.identifier.uri | http://hdl.handle.net/1942/29117 | - |
dc.description.abstract | Background The aim of this study was to investigate the impact of ticagrelor monotherapy following 1-month dual antiplatelet therapy (DAPT) after percutaneous coronary intervention (PCI) for bifurcation lesions. Methods GLOBAL LEADERS was a randomized, superiority, all-comers trial comparing 1-month DAPT with ticagrelor and aspirin followed by 23-month ticagrelor monotherapy (experimental treatment) with standard 12-month DAPT followed by 12-month aspirin monotherapy (reference treatment) in patients treated with a biolimus A9-eluting stent. The primary endpoint was a composite of all-cause death or new Q-wave myocardial infarction (MI) at 2 years. Results Among the 15,845 patients included in this subgroup analysis, 2,498 patients (15.8%) underwent PCI for at least one bifurcation lesion. The incidence of the primary endpoint was similar between the bifurcation and nonbifurcation groups (4.7 vs. 4.0%, p = .083). The experimental treatment had no significant effect on the primary endpoint according to the presence/absence of a bifurcation lesion (bifurcation: hazard ratio [HR]: 0.74, 95% confidence interval [CI]: 0.51-1.07; nonbifurcation: HR: 0.90, 95% CI: 0.76-1.07, p for interaction = .343), but was associated with significant reduction in definite or probable stent thrombosis (p for interaction = .022) and significant excess of stroke (p for interaction = .018) when compared with the reference treatment. Conclusions After PCI for bifurcation lesions using 1-month of DAPT followed by ticagrelor monotherapy for 23 months did not demonstrate explicit benefit regarding all-cause death or new Q-wave MI as in the overall trial. | - |
dc.description.sponsorship | AstraZeneca; Biosensors International Group; Medicines company | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.rights | 2019 Wiley Periodicals, Inc. | - |
dc.subject.other | antiplatelet treatment | - |
dc.subject.other | bifurcation lesion | - |
dc.subject.other | drug-eluting stents | - |
dc.subject.other | Percutaneous coronary intervention | - |
dc.title | Clinical relevance of ticagrelor monotherapy following 1-month dual antiplatelet therapy after bifurcation percutaneous coronary intervention: Insight from GLOBAL LEADERS trial | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 111 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 100 | - |
dc.identifier.volume | 96 | - |
local.format.pages | 12 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Kogame, Norihiro; Chichareon, Ply; Takahashi, Kuniaki; Modolo, Rodrigo; Komiyama, Hidenori] Amsterdam Univ Med Ctr, Dept Cardiol, Amsterdam, Netherlands. [Kogame, Norihiro] Toho Univ, Dept Cardiol, Med Ctr, Ohashi Hosp, Tokyo, Japan. [Chichareon, Ply] Prince Songkla Univ, Fac Med, Dept Internal Med, Div Cardiol, Hat Yai, Thailand. [De Wilder, Kenneth; Janssens, Luc] Imelda Hosp Bonheiden, Heart Ctr, Bonheiden, Belgium. [Modolo, Rodrigo] Univ Estadual Campinas, UNICAMP, Dept Internal Med, Cardiol Div, Campinas, SP, Brazil. [Chang, Chun Chin; Tomaniak, Mariusz; Onuma, Yoshinobu] Erasmus MC, Thoraxctr, Dept Intervent Cardiol, Rotterdam, Netherlands. [Chieffo, Alaide] IRCCS San Raffaele Sci Inst, Intervent Cardiol Unit, Milan, Italy. [Colombo, Antonio] Villa Maria Cecila Hosp GVM, Intervent Cardiol Unit, Cotignola, RA, Italy. [Garg, Scot] Royal Blackburn Hosp, Dept Cardiol, Blackburn, Lancs, England. [Louvard, Yves] Hop Prive Jacques Cartier, Inst Cardiovasc Paris Sud, Ramsay Gen Sante, Dept Cardiol, Massy, France. [Juni, Peter] St Michaels Hosp, Li Ka Shing Knowledge Inst, Appl Hlth Res Ctr, Toronto, ON, Canada. [Juni, Peter] Univ Toronto, Dept Med, Toronto, ON, Canada. [Juni, Peter] Univ Toronto, Inst Hlth Policy Management & Evaluat, Toronto, ON, Canada. [Steg, Philippe G.] Univ Paris Diderot, FACT, Paris, France. [Hamm, Christian] Univ Giessen, Kerckhoff Heart & Thorax Ctr, Giessen, Germany. [Vranckx, Pascal] Jessa Ziekenhuis Hasselt Univ, Fac Med & Life Sci, Hasselt, Belgium. [Valgimigli, Marco; Windecker, Stephan] Univ Bern, Dept Cardiol, Inselspital, Bern, Switzerland. [Stoll, Hans-Peter] Biosensors Clin Res, Morges, Switzerland. [Serruys, Patrick W.] Imperial Coll London, Int Ctr Circulatory Hlth, London, England. | - |
local.publisher.place | HOBOKEN | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1002/ccd.28428 | - |
dc.identifier.pmid | 31410968 | - |
dc.identifier.isi | 000480814500001 | - |
dc.identifier.eissn | 1522-726X | - |
local.provider.type | PubMed | - |
local.uhasselt.international | yes | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2020 | - |
item.accessRights | Open Access | - |
item.fullcitation | Kogame, Norihiro; Chichareon, Ply; De Wilder, Kenneth; Takahashi, Kuniaki; Modolo, Rodrigo; Chang, Chun Chin; Tomaniak, Mariusz; Komiyama, Hidenori; Chieffo, Alaide; Colombo, Antonio; Garg, Scot; Louvard, Yves; Juni, Peter; Steg, Philippe G.; Hamm, Christian; VRANCKX, Pascal; Valgimigli, Marco; Windecker, Stephan; Stoll, Hans-Peter; Onuma, Yoshinobu; Janssens, Luc & Serruys, Patrick W. (2020) Clinical relevance of ticagrelor monotherapy following 1-month dual antiplatelet therapy after bifurcation percutaneous coronary intervention: Insight from GLOBAL LEADERS trial. In: CATHETERIZATION AND CARDIOVASCULAR INTERVENTIONS, 96 (1), p. 100-111. | - |
item.contributor | Kogame, Norihiro | - |
item.contributor | Chichareon, Ply | - |
item.contributor | De Wilder, Kenneth | - |
item.contributor | Takahashi, Kuniaki | - |
item.contributor | Modolo, Rodrigo | - |
item.contributor | Chang, Chun Chin | - |
item.contributor | Tomaniak, Mariusz | - |
item.contributor | Komiyama, Hidenori | - |
item.contributor | Chieffo, Alaide | - |
item.contributor | Colombo, Antonio | - |
item.contributor | Garg, Scot | - |
item.contributor | Louvard, Yves | - |
item.contributor | Juni, Peter | - |
item.contributor | Steg, Philippe G. | - |
item.contributor | Hamm, Christian | - |
item.contributor | VRANCKX, Pascal | - |
item.contributor | Valgimigli, Marco | - |
item.contributor | Windecker, Stephan | - |
item.contributor | Stoll, Hans-Peter | - |
item.contributor | Onuma, Yoshinobu | - |
item.contributor | Janssens, Luc | - |
item.contributor | Serruys, Patrick W. | - |
crisitem.journal.issn | 1522-1946 | - |
crisitem.journal.eissn | 1522-726X | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Bifurcation_GL_manuscript_with_Figure (5).pdf | Peer-reviewed author version | 1.57 MB | Adobe PDF | View/Open |
Cathet Cardio Intervent - 2019 - Kogame - Clinical relevance of ticagrelor monotherapy following 1‐month dual antiplatelet.pdf Restricted Access | Published version | 2.14 MB | Adobe PDF | View/Open Request a copy |
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