Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/29168
Title: | Quantity and quality of antibodies after acellular versus whole cell pertussis vaccines in infants born to mothers who received Tdap during pregnancy: a randomised trial | Authors: | Wanlapakorn, N. Maertens, K. Peunpa, J. TRAN, Mai Phuong Thao HENS, Niel Van Damme, P. Thiriard, A. Raze, D. Locht, C. Poovorawan, Y. Leuridan, E. |
Issue Date: | 2020 | Publisher: | OXFORD UNIV PRESS INC | Source: | Clinical infectious diseases, 71 (1), p. 72-80 | Abstract: | Background The blunting effect of maternal pertussis immunization during pregnancy on infant antibody responses induced by whole cell pertussis (wP) vaccination is not well-defined. Methods This randomized controlled trial (NCT02408926) followed term infants born to mothers vaccinated with tetanus-diphtheria-acellular pertussis (Tdap)-vaccine during pregnancy in Thailand. Infants received either acellular pertussis (aP)- or wP-containing vaccine at 2, 4, 6 and 18 months of age. A comparison group comprised wP-vaccinated children born to mothers not vaccinated during pregnancy. Antibodies against pertussis toxin (PT), filamentous haemagglutinin (FHA) and pertactin (PRN) were evaluated using commercial enzyme-linked immunosorbent assays (ELISA). Functionality of antibodies against B. pertussis was measured using B. pertussis growth inhibition assay (BGIA). Results After maternal Tdap vaccination, 158 infants vaccinated with aP-containing vaccines possessed higher antibody levels (p < 0.001) against all tested B. pertussis antigens post-priming compared to 157 infants receiving wP-containing vaccines. At one-month post-booster, only anti-FHA and anti-PRN antibodies were still significantly higher (p < 0.001) in the aP group. Significantly higher anti-PT and anti-FHA (p < 0.001), but not anti-PRN IgG, were observed among 69 wP-vaccinated infants born to control mothers compared to wP-vaccinated infants of Tdap-vaccinated mothers after primary and booster vaccination. The antibody functionality was higher in all wP vaccinated infants at all times. Conclusions Maternal Tdap vaccination inhibited more pertussis-specific responses in wP vaccinated infants compared to aP vaccinated infants, and the control group of unvaccinated women had highest pertussis-specific responses, persisting until after the booster dose. Antibody functionality was better in the wP groups. | Notes: | Topic: action potentials pregnancy atrioventricular accessory pathway alkaline phosphatase alpha-2 antiplasmin immunization infant mothers pertussis vaccine randomization vaccination vaccines antibodies pertussis | Keywords: | pertussis;pregnancy;maternal immunization;humoral immune response;functionality | Document URI: | http://hdl.handle.net/1942/29168 | Link to publication/dataset: | https://doi.org/10.1093/cid/ciz778 | ISSN: | 1058-4838 | e-ISSN: | 1537-6591 | DOI: | 10.1093/cid/ciz778 | ISI #: | WOS:000551523900014 | Rights: | The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com. This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2021 |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
auteurversie_CID_Quantity and quality of antibodies after acellular versus whole cell pertussis vaccines in infants born.pdf | Peer-reviewed author version | 922.25 kB | Adobe PDF | View/Open |
WEB OF SCIENCETM
Citations
38
checked on Oct 12, 2024
Page view(s)
78
checked on May 20, 2022
Download(s)
480
checked on May 20, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.