Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/29177
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | MAZON CABRERA, Rut | - |
dc.contributor.author | VANDORMAEL, Patrick | - |
dc.contributor.author | SOMERS, Veerle | - |
dc.date.accessioned | 2019-09-13T09:32:23Z | - |
dc.date.available | 2019-09-13T09:32:23Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | FRONTIERS IN IMMUNOLOGY, 10 (Art N° 1474) | - |
dc.identifier.issn | 1664-3224 | - |
dc.identifier.uri | http://hdl.handle.net/1942/29177 | - |
dc.description.abstract | Autism spectrum disorder (ASD) is a neurodevelopmental disorder whose behavioral symptoms become apparent in early childhood. The underlying pathophysiological mechanisms are only partially understood and the clinical manifestations are heterogeneous in nature, which poses a major challenge for diagnosis, prognosis and intervention. In the last years, an important role of a dysregulated immune system in ASD has emerged, but the mechanisms connecting this to a disruption of brain development are still largely unknown. Although ASD is not considered as a typical autoimmune disease, self-reactive antibodies or autoantibodies against a wide variety of targets have been found in a subset of ASD patients. In addition, autoantibodies reactive to fetal brain proteins have also been described in the prenatal stage of neurodevelopment, where they can be transferred from the mother to the fetus by transplacental transport. In this review, we give an extensive overview of the antibodies described in ASD according to their target antigens, their different origins, and timing of exposure during neurodevelopment. | - |
dc.description.sponsorship | The authors received financial support from the Research Foundation-Flanders (SB-FWO, 1S54717N, RM-C, Maternal antibodies as early biomarkers for Autism Spectrum Disorder) and the Simons Foundation Autism Research Initiative-Explorer Award (SFARI, 534849, VS, Maternal antibodies as early biomarkers for Autism Spectrum Disorder). | - |
dc.language.iso | en | - |
dc.publisher | FRONTIERS MEDIA SA | - |
dc.rights | © 2019 Mazón-Cabrera, Vandormael and Somers. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY) | - |
dc.subject.other | autism; immunoglobulins; brain antigens; neurodevelopement; placental transfer | - |
dc.subject.other | autism; immunoglobulins; brain antigens; neurodevelopement; placental transfer | - |
dc.title | Antigenic Targets of Patient and Maternal Autoantibodies in Autism Spectrum Disorder | - |
dc.type | Journal Contribution | - |
dc.identifier.volume | 10 | - |
local.format.pages | 18 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Mazon-Cabrera, Rut; Vandormael, Patrick; Somers, Veerle] Hasselt Univ, Biomed Res Inst, Fac Med & Life Sci, Diepenbeek, Belgium. | - |
local.publisher.place | LAUSANNE | - |
local.type.refereed | Refereed | - |
local.type.specified | Review | - |
local.bibliographicCitation.artnr | 1474 | - |
dc.identifier.doi | 10.3389/fimmu.2019.01474 | - |
dc.identifier.isi | 000476740400001 | - |
item.validation | ecoom 2020 | - |
item.accessRights | Open Access | - |
item.fullcitation | MAZON CABRERA, Rut; VANDORMAEL, Patrick & SOMERS, Veerle (2019) Antigenic Targets of Patient and Maternal Autoantibodies in Autism Spectrum Disorder. In: FRONTIERS IN IMMUNOLOGY, 10 (Art N° 1474). | - |
item.fulltext | With Fulltext | - |
item.contributor | MAZON CABRERA, Rut | - |
item.contributor | VANDORMAEL, Patrick | - |
item.contributor | SOMERS, Veerle | - |
crisitem.journal.issn | 1664-3224 | - |
crisitem.journal.eissn | 1664-3224 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
mazon 1.pdf | Published version | 781.81 kB | Adobe PDF | View/Open |
WEB OF SCIENCETM
Citations
14
checked on May 8, 2024
Page view(s)
128
checked on Jun 30, 2022
Download(s)
168
checked on Jun 30, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.