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http://hdl.handle.net/1942/29183
Title: | Systemic BCG infection in a patient with pancytopaenia and fever 9 years after intravesical BCG administration for bladder cancer | Authors: | Westhovens, I.M. Vandenabeele, M. E. MESSIAEN, Peter VAN DER HILST, Jeroen |
Issue Date: | 2016 | Publisher: | Source: | BMJ case reports, 2016, (Art N° bcr2016215599). | Abstract: | BCG is an attenuated live strain of Mycobacterium bovis that is used as an intravesical immunotherapy for superficial bladder cancer. Although generally well tolerated, BCG instillation can lead to systemic diseases. We present a case of a 75-year-old man who was treated for recurrent localised transitional cell carcinoma (TCC) of the bladder with intravesical instillation of BCG in 2006. His medical history included Parkinson’s disease. The patient reported worsening of Parkinson symptoms in the preceding month. In addition, he had progressive pancytopaenia and a bone marrow biopsy showed a granulomatous inflammatory infiltrate. Cultures from bone marrow aspiration grew M. bovis. He was successfully treated with tuberculostatic drugs and made a full recovery. In addition, there was partial amelioration of the Parkinson symptoms. This case shows that physicians should be aware that BCG instillation for TCC can cause systemic disease even years after treatment | Document URI: | http://hdl.handle.net/1942/29183 | e-ISSN: | 1757-790X | DOI: | 10.1136/bcr-2016-215599 | Category: | A1 | Type: | Journal Contribution | Validations: | vabb 2021 |
Appears in Collections: | Research publications |
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