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http://hdl.handle.net/1942/29189
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DC Field | Value | Language |
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dc.contributor.author | Baan, Adrienn | - |
dc.contributor.author | ADRIAENSENS, Peter | - |
dc.contributor.author | Lammens, Joris | - |
dc.contributor.author | Delgado Hernandez, Rene | - |
dc.contributor.author | Vanden Berghe, Wim | - |
dc.contributor.author | Pieters, Luc | - |
dc.contributor.author | Vervaet, Chris | - |
dc.contributor.author | Kiekens, Filip | - |
dc.date.accessioned | 2019-09-16T08:37:04Z | - |
dc.date.available | 2019-09-16T08:37:04Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 141, p. 172-179 | - |
dc.identifier.issn | 0939-6411 | - |
dc.identifier.uri | http://hdl.handle.net/1942/29189 | - |
dc.description.abstract | Mangiferin, a poorly water soluble compound, was processed via a dry amorphisation technique (ball milling) in combination with mesoporous silica to enhance the solubility of mangiferin. The amorphous samples were prepared by mixing 1:1 (w/w) Syloid (R) XDP 3050 silica-mangiferin mixtures using a planetary mono mill at different milling speeds and milling times according to a 32 full factorial experimental design. The prepared samples were characterized for dissolution profile, particle size distribution using laser diffraction particle size analyzer, thermal characteristics using DSC, crystalline characteristics using XRD and molecular interactions using FTIR and ss-NMR. The samples were tested for stability at stress conditions (40 degrees C/75%RH) for up to 6 months in open and closed containers. To improve stability of the samples, mixtures of 1:1:2 mangiferin-polymer (Soluplus or HPMC)-silica samples were also prepared and analyzed. Amorphisation of mangiferin is possible using dry amorphisation by ball milling with mesoporous silica in a short amount of time. The amorphisation rate of the samples improved with the energy input of the milling process. The samples prepared with high energy input resulted in amorphous samples and showed a better stability at the stress conditions for up to 3 months. Solubility of these samples increased from 0.32 to 0.50 mg/ml and the particle size decreased from 35.5 mu m to around 7 mu m. The spectral analysis suggest presence of interactions between the silica material and the compound. The amorphous stability was improved with addition of polymer, even though the solubility of the samples was lower. | - |
dc.description.sponsorship | Many thanks to everyone involved in this research. We specifically thank Fred Monsuur (W. R. Grace & co., Worms, Germany) for the scientific support and discussions and for providing us the SEM/SEMEDX pictures. This project is part of an International collaboration (VLIR-UOS (Belgium) TEAM project no. ZEIN2016PR418). | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.rights | 2019 Elsevier B.V. All rights reserved. | - |
dc.subject.other | Mesoporous silica; Solid dispersions; Dry amorphisation; Co-milling; Drug formulation; Solubility improvement | - |
dc.subject.other | Mesoporous silica; Solid dispersions; Dry amorphisation; Co-milling; Drug formulation; Solubility improvement | - |
dc.title | Dry amorphisation of mangiferin, a poorly water-soluble compound, using mesoporous silica | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 179 | - |
dc.identifier.spage | 172 | - |
dc.identifier.volume | 141 | - |
local.format.pages | 8 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Baan, Adrienn; Kiekens, Filip] Univ Antwerp, Dept Pharmaceut Technol & Biopharm, Univ Pl 1, B-2610 Antwerp, Belgium. [Adriaensens, Peter] Univ Hasselt, Inst Mat Res, Agoralaan Bldg D, B-3590 Diepenbeek, Belgium. [Lammens, Joris; Vervaet, Chris] Univ Ghent, Lab Pharmaceut Technol, Ottergemsesteenweg 460, B-9000 Ghent, Belgium. [Delgado Hernandez, Rene] Univ La Habana, Inst Farm & Alimentos, Havana 222, Cuba. [Vanden Berghe, Wim] Univ Antwerp, Dept Biomed Sci, Univ Pl 1, B-2610 Antwerp, Belgium. [Pieters, Luc] Univ Antwerp, Dept Pharmaceut Sci, Univ Pl 1, B-2610 Antwerp, Belgium. | - |
local.publisher.place | AMSTERDAM | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.ejpb.2019.05.026 | - |
dc.identifier.isi | 000476961600017 | - |
item.fulltext | With Fulltext | - |
item.fullcitation | Baan, Adrienn; ADRIAENSENS, Peter; Lammens, Joris; Delgado Hernandez, Rene; Vanden Berghe, Wim; Pieters, Luc; Vervaet, Chris & Kiekens, Filip (2019) Dry amorphisation of mangiferin, a poorly water-soluble compound, using mesoporous silica. In: EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 141, p. 172-179. | - |
item.accessRights | Restricted Access | - |
item.validation | ecoom 2020 | - |
item.contributor | Baan, Adrienn | - |
item.contributor | ADRIAENSENS, Peter | - |
item.contributor | Lammens, Joris | - |
item.contributor | Delgado Hernandez, Rene | - |
item.contributor | Vanden Berghe, Wim | - |
item.contributor | Pieters, Luc | - |
item.contributor | Vervaet, Chris | - |
item.contributor | Kiekens, Filip | - |
crisitem.journal.issn | 0939-6411 | - |
crisitem.journal.eissn | 1873-3441 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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baan 1.pdf Restricted Access | Published version | 1.9 MB | Adobe PDF | View/Open Request a copy |
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