Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/29543
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dc.contributor.authorMenden, Michael P.-
dc.contributor.authorWang, Dennis-
dc.contributor.authorMason, Mike J.-
dc.contributor.authorSzalai, Bence-
dc.contributor.authorBulusu, Krishna C.-
dc.contributor.authorGuan, Yuanfang-
dc.contributor.authorYu, Thomas-
dc.contributor.authorKang, Jaewoo-
dc.contributor.authorJeon, Minji-
dc.contributor.authorWolfinger, Russ-
dc.contributor.authorNguyen, Tin-
dc.contributor.authorZaslavskiy, Mikhail-
dc.contributor.authorJang, In Sock-
dc.contributor.authorGhazoui, Zara-
dc.contributor.authorAhsen, Mehmet Eren-
dc.contributor.authorVogel, Robert-
dc.contributor.authorNeto, Elias Chaibub-
dc.contributor.authorNorman, Thea-
dc.contributor.authorTang, Eric K. Y.-
dc.contributor.authorGarnett, Mathew J.-
dc.contributor.authorDi Veroli, Giovanni Y.-
dc.contributor.authorFawell, Stephen-
dc.contributor.authorStolovitzky, Gustavo-
dc.contributor.authorGuinney, Justin-
dc.contributor.authorDry, Jonathan R.-
dc.contributor.authorSaez-Rodriguez, Julio-
dc.contributor.authorAbante, Jordi-
dc.contributor.authorAbecassis, Barbara Schmitz-
dc.contributor.authorAben, Nanne-
dc.contributor.authorAghamirzaie, Delasa-
dc.contributor.authorAittokallio, Tero-
dc.contributor.authorAkhtari, Farida S.-
dc.contributor.authorAl-lazikani, Bissan-
dc.contributor.authorAlam, Tanvir-
dc.contributor.authorAllam, Amin-
dc.contributor.authorAllen, Chad-
dc.contributor.authorde Almeida, Mariana Pelicano-
dc.contributor.authorAltarawy, Doaa-
dc.contributor.authorAlves, Vinicius-
dc.contributor.authorAmadoz, Alicia-
dc.contributor.authorAnchang, Benedict-
dc.contributor.authorAntolin, Albert A.-
dc.contributor.authorAsh, Jeremy R.-
dc.contributor.authorRomeo Aznar, Victoria-
dc.contributor.authorBa-alawi, Wail-
dc.contributor.authorBagheri, Moeen-
dc.contributor.authorBajic, Vladimir-
dc.contributor.authorBall, Gordon-
dc.contributor.authorBallester, Pedro J.-
dc.contributor.authorBaptista, Delora-
dc.contributor.authorBare, Christopher-
dc.contributor.authorBateson, Mathilde-
dc.contributor.authorBender, Andreas-
dc.contributor.authorBertrand, Denis-
dc.contributor.authorWijayawardena, Bhagya-
dc.contributor.authorBoroevich, Keith A.-
dc.contributor.authorBosdriesz, Evert-
dc.contributor.authorBougouffa, Salim-
dc.contributor.authorBounova, Gergana-
dc.contributor.authorBrouwer, Thomas-
dc.contributor.authorBryant, Barbara-
dc.contributor.authorCalaza, Manuel-
dc.contributor.authorCalderone, Alberto-
dc.contributor.authorCalza, Stefano-
dc.contributor.authorCapuzzi, Stephen-
dc.contributor.authorCarbonell-Caballero, Jose-
dc.contributor.authorCarlin, Daniel-
dc.contributor.authorCarter, Hannah-
dc.contributor.authorCastagnoli, Luisa-
dc.contributor.authorCelebi, Remzi-
dc.contributor.authorCesareni, Gianni-
dc.contributor.authorChang, Hyeokyoon-
dc.contributor.authorChen, Guocai-
dc.contributor.authorChen, Haoran-
dc.contributor.authorChen, Huiyuan-
dc.contributor.authorCheng, Lijun-
dc.contributor.authorChernomoretz, Ariel-
dc.contributor.authorChicco, Davide-
dc.contributor.authorCho, Kwang-Hyun-
dc.contributor.authorCho, Sunghwan-
dc.contributor.authorChoi, Daeseon-
dc.contributor.authorChoi, Jaejoon-
dc.contributor.authorChoi, Kwanghun-
dc.contributor.authorChoi, Minsoo-
dc.contributor.authorDe Cock, Martine-
dc.contributor.authorCoker, Elizabeth-
dc.contributor.authorCortes-Ciriano, Isidro-
dc.contributor.authorCserzo, Miklos-
dc.contributor.authorCubuk, Cankut-
dc.contributor.authorCurtis, Christina-
dc.contributor.authorVan Daele, Dries-
dc.contributor.authorDang, Cuong C.-
dc.contributor.authorDijkstra, Tjeerd-
dc.contributor.authorDopazo, Joaquin-
dc.contributor.authorDraghici, Sorin-
dc.contributor.authorDrosou, Anastasios-
dc.contributor.authorDumontier, Michel-
dc.contributor.authorEhrhart, Friederike-
dc.contributor.authorEid, Fatma-Elzahraa-
dc.contributor.authorElHefnawi, Mahmoud-
dc.contributor.authorElmarakeby, Haitham-
dc.contributor.authorvan Engelen, Bo-
dc.contributor.authorEngin, Hatice Billur-
dc.contributor.authorde Esch, Iwan-
dc.contributor.authorEVELO, Chris-
dc.contributor.authorFalcao, Andre O.-
dc.contributor.authorFarag, Sherif-
dc.contributor.authorFernandez-Lozano, Carlos-
dc.contributor.authorFisch, Kathleen-
dc.contributor.authorFlobak, Asmund-
dc.contributor.authorFornari, Chiara-
dc.contributor.authorForoushani, Amir B. K.-
dc.contributor.authorFotso, Donatien Chedom-
dc.contributor.authorFourches, Denis-
dc.contributor.authorFriend, Stephen-
dc.contributor.authorFrigessi, Arnoldo-
dc.contributor.authorGao, Feng-
dc.contributor.authorGao, Xiaoting-
dc.contributor.authorGerold, Jeffrey M.-
dc.contributor.authorGestraud, Pierre-
dc.contributor.authorGhosh, Samik-
dc.contributor.authorGillberg, Jussi-
dc.contributor.authorGodoy-Lorite, Antonia-
dc.contributor.authorGodynyuk, Lizzy-
dc.contributor.authorGodzik, Adam-
dc.contributor.authorGoldenberg, Anna-
dc.contributor.authorGomez-Cabrero, David-
dc.contributor.authorGonen, Mehmet-
dc.contributor.authorde Graaf, Chris-
dc.contributor.authorGray, Harry-
dc.contributor.authorGrechkin, Maxim-
dc.contributor.authorGuimera, Roger-
dc.contributor.authorGuney, Emre-
dc.contributor.authorHaibe-Kains, Benjamin-
dc.contributor.authorHan, Younghyun-
dc.contributor.authorHase, Takeshi-
dc.contributor.authorHe, Di-
dc.contributor.authorHe, Liye-
dc.contributor.authorHeath, Lenwood S.-
dc.contributor.authorHellton, Kristoffer H.-
dc.contributor.authorHelmer-Citterich, Manuela-
dc.contributor.authorHidalgo, Marta R.-
dc.contributor.authorHidru, Daniel-
dc.contributor.authorHill, Steven M.-
dc.contributor.authorHochreiter, Sepp-
dc.contributor.authorHong, Seungpyo-
dc.contributor.authorHovig, Eivind-
dc.contributor.authorHsueh, Ya-Chih-
dc.contributor.authorHu, Zhiyuan-
dc.contributor.authorHuang, Justin K.-
dc.contributor.authorHuang, R. Stephanie-
dc.contributor.authorHunyady, Laszlo-
dc.contributor.authorHwang, Jinseub-
dc.contributor.authorHwang, Tae Hyun-
dc.contributor.authorHwang, Woochang-
dc.contributor.authorHwang, Yongdeuk-
dc.contributor.authorIsayev, Olexandr-
dc.contributor.authorWalk, Oliver Bear Don't-
dc.contributor.authorJack, John-
dc.contributor.authorJahandideh, Samad-
dc.contributor.authorJi, Jiadong-
dc.contributor.authorJo, Yousang-
dc.contributor.authorKamola, Piotr J.-
dc.contributor.authorKanev, Georgi K.-
dc.contributor.authorKaracosta, Loukia-
dc.contributor.authorKarimi, Mostafa-
dc.contributor.authorKaski, Samuel-
dc.contributor.authorKazanov, Marat-
dc.contributor.authorKhamis, Abdullah M.-
dc.contributor.authorKhan, Suleiman Ali-
dc.contributor.authorKiani, Narsis A.-
dc.contributor.authorKim, Allen-
dc.contributor.authorKim, Jinhan-
dc.contributor.authorKim, Juntae-
dc.contributor.authorKim, Kiseong-
dc.contributor.authorKim, Kyung-
dc.contributor.authorKim, Sunkyu-
dc.contributor.authorKim, Yongsoo-
dc.contributor.authorKim, Yunseong-
dc.contributor.authorKirk, Paul D. W.-
dc.contributor.authorKitano, Hiroaki-
dc.contributor.authorKlambauer, Gunter-
dc.contributor.authorKnowles, David-
dc.contributor.authorKo, Melissa-
dc.contributor.authorKohn-Luque, Alvaro-
dc.contributor.authorKooistra, Albert J.-
dc.contributor.authorKuenemann, Melaine A.-
dc.contributor.authorKuiper, Martin-
dc.contributor.authorKurz, Christoph-
dc.contributor.authorKwon, Mijin-
dc.contributor.authorvan Laarhoven, Twan-
dc.contributor.authorLaegreid, Astrid-
dc.contributor.authorLederer, Simone-
dc.contributor.authorLee, Heewon-
dc.contributor.authorLee, Jeon-
dc.contributor.authorLee, Yun Woo-
dc.contributor.authorLeppaho, Eemeli-
dc.contributor.authorLewis, Richard-
dc.contributor.authorLi, Jing-
dc.contributor.authorLi, Lang-
dc.contributor.authorLiley, James-
dc.contributor.authorLim, Weng Khong-
dc.contributor.authorLin, Chieh-
dc.contributor.authorLiu, Yiyi-
dc.contributor.authorLopez, Yosvany-
dc.contributor.authorLow, Joshua-
dc.contributor.authorLysenko, Artem-
dc.contributor.authorMachado, Daniel-
dc.contributor.authorMadhukar, Neel-
dc.contributor.authorDe Maeyer, Dries-
dc.contributor.authorMalpartida, Ana Belen-
dc.contributor.authorMamitsuka, Hiroshi-
dc.contributor.authorMarabita, Francesco-
dc.contributor.authorMarchal, Kathleen-
dc.contributor.authorMarttinen, Pekka-
dc.contributor.authorMason, Daniel-
dc.contributor.authorMazaheri, Alireza-
dc.contributor.authorMehmood, Arfa-
dc.contributor.authorMehreen, Ali-
dc.contributor.authorMichaut, Magali-
dc.contributor.authorMiller, Ryan A.-
dc.contributor.authorMitsopoulos, Costas-
dc.contributor.authorModos, Dezso-
dc.contributor.authorVAN MOERBEKE, Marijke-
dc.contributor.authorMoo, Keagan-
dc.contributor.authorMotsinger-Reif, Alison-
dc.contributor.authorMovva, Rajiv-
dc.contributor.authorMuraru, Sebastian-
dc.contributor.authorMuratov, Eugene-
dc.contributor.authorMushthofa, Mushthofa-
dc.contributor.authorNagarajan, Niranjan-
dc.contributor.authorNakken, Sigve-
dc.contributor.authorNath, Aritro-
dc.contributor.authorNeuvial, Pierre-
dc.contributor.authorNewton, Richard-
dc.contributor.authorNing, Zheng-
dc.contributor.authorDe Niz, Carlos-
dc.contributor.authorOliva, Baldo-
dc.contributor.authorOlsen, Catharina-
dc.contributor.authorPalmeri, Antonio-
dc.contributor.authorPanesar, Bhawan-
dc.contributor.authorPapadopoulos, Stavros-
dc.contributor.authorPark, Jaesub-
dc.contributor.authorPark, Seonyeong-
dc.contributor.authorPark, Sungjoon-
dc.contributor.authorPawitan, Yudi-
dc.contributor.authorPeluso, Daniele-
dc.contributor.authorPendyala, Sriram-
dc.contributor.authorPeng, Jian-
dc.contributor.authorPerfetto, Livia-
dc.contributor.authorPirro, Stefano-
dc.contributor.authorPlevritis, Sylvia-
dc.contributor.authorPoliti, Regina-
dc.contributor.authorPoon, Hoifung-
dc.contributor.authorPorta, Eduard-
dc.contributor.authorPrellner, Isak-
dc.contributor.authorPreuer, Kristina-
dc.contributor.authorAngel Pujana, Miguel-
dc.contributor.authorRamnarine, Ricardo-
dc.contributor.authorReid, John E.-
dc.contributor.authorReyal, Fabien-
dc.contributor.authorRichardson, Sylvia-
dc.contributor.authorRicketts, Camir-
dc.contributor.authorRieswijk, Linda-
dc.contributor.authorRocha, Miguel-
dc.contributor.authorRodriguez-Gonzalvez, Carmen-
dc.contributor.authorRoell, Kyle-
dc.contributor.authorRotroff, Daniel-
dc.contributor.authorde Ruiter, Julian R.-
dc.contributor.authorRukawa, Ploy-
dc.contributor.authorSadacca, Benjamin-
dc.contributor.authorSafikhani, Zhaleh-
dc.contributor.authorSafitri, Fita-
dc.contributor.authorSales-Pardo, Marta-
dc.contributor.authorSauer, Sebastian-
dc.contributor.authorSchlichting, Moritz-
dc.contributor.authorSeoane, Jose A.-
dc.contributor.authorSerra, Jordi-
dc.contributor.authorShang, Ming-Mei-
dc.contributor.authorSharma, Alok-
dc.contributor.authorSharma, Hari-
dc.contributor.authorShen, Yang-
dc.contributor.authorShiga, Motoki-
dc.contributor.authorShin, Moonshik-
dc.contributor.authorSHKEDY, Ziv-
dc.contributor.authorShopsowitz, Kevin-
dc.contributor.authorSinai, Sam-
dc.contributor.authorSkola, Dylan-
dc.contributor.authorSmirnov, Petr-
dc.contributor.authorSoerensen, Izel Fourie-
dc.contributor.authorSoerensen, Peter-
dc.contributor.authorSong, Je-Hoon-
dc.contributor.authorSong, Sang Ok-
dc.contributor.authorSoufan, Othman-
dc.contributor.authorSpitzmueller, Andreas-
dc.contributor.authorSteipe, Boris-
dc.contributor.authorSuphavilai, Chayaporn-
dc.contributor.authorTamayo, Sergio Pulido-
dc.contributor.authorTamborero, David-
dc.contributor.authorTang, Jing-
dc.contributor.authorTanoli, Zia-ur-Rehman-
dc.contributor.authorTarres-Deulofeu, Marc-
dc.contributor.authorTegner, Jesper-
dc.contributor.authorThommesen, Liv-
dc.contributor.authorTonekaboni, Seyed Ali Madani-
dc.contributor.authorTran, Hong-
dc.contributor.authorDE TROYER, Ewoud-
dc.contributor.authorTruong, Amy-
dc.contributor.authorTsunoda, Tatsuhiko-
dc.contributor.authorTuru, Gabor-
dc.contributor.authorTzeng, Guang-Yo-
dc.contributor.authorVerbeke, Lieven-
dc.contributor.authorVidela, Santiago-
dc.contributor.authorVis, Daniel-
dc.contributor.authorVoronkov, Andrey-
dc.contributor.authorVotis, Konstantinos-
dc.contributor.authorWang, Ashley-
dc.contributor.authorWang, Hong-Qiang Horace-
dc.contributor.authorWang, Po-Wei-
dc.contributor.authorWang, Sheng-
dc.contributor.authorWANG, Weixin-
dc.contributor.authorWang, Xiaochen-
dc.contributor.authorWang, Xin-
dc.contributor.authorWennerberg, Krister-
dc.contributor.authorWernisch, Lorenz-
dc.contributor.authorWessels, Lodewyk-
dc.contributor.authorvan Westen, Gerard J. P.-
dc.contributor.authorWesterman, Bart A.-
dc.contributor.authorWhite, Simon Richard-
dc.contributor.authorWillighagen, Egon-
dc.contributor.authorWurdinger, Tom-
dc.contributor.authorXie, Lei-
dc.contributor.authorXie, Shuilian-
dc.contributor.authorXu, Hua-
dc.contributor.authorYadav, Bhagwan-
dc.contributor.authorYau, Christopher-
dc.contributor.authorYeerna, Huwate-
dc.contributor.authorYin, Jia Wei-
dc.contributor.authorYu, Michael-
dc.contributor.authorYu, MinHwan-
dc.contributor.authorYun, So Jeong-
dc.contributor.authorZakharov, Alexey-
dc.contributor.authorZamichos, Alexandros-
dc.contributor.authorZanin, Massimiliano-
dc.contributor.authorZeng, Li-
dc.contributor.authorZenil, Hector-
dc.contributor.authorZhang, Frederick-
dc.contributor.authorZhang, Pengyue-
dc.contributor.authorZhang, Wei-
dc.contributor.authorZhao, Hongyu-
dc.contributor.authorZhao, Lan-
dc.contributor.authorZheng, Wenjin-
dc.contributor.authorZoufir, Azedine-
dc.contributor.authorZucknick, Manuela-
dc.date.accessioned2019-09-18T12:36:28Z-
dc.date.available2019-09-18T12:36:28Z-
dc.date.issued2019-
dc.identifier.citationNATURE COMMUNICATIONS, 10 (Art N° 2674)-
dc.identifier.issn2041-1723-
dc.identifier.urihttp://hdl.handle.net/1942/29543-
dc.description.abstractThe effectiveness of most cancer targeted therapies is short-lived. Tumors often develop resistance that might be overcome with drug combinations. However, the number of possible combinations is vast, necessitating data-driven approaches to find optimal patient-specific treatments. Here we report AstraZeneca's large drug combination dataset, consisting of 11,576 experiments from 910 combinations across 85 molecularly characterized cancer cell lines, and results of a DREAM Challenge to evaluate computational strategies for predicting synergistic drug pairs and biomarkers. 160 teams participated to provide a comprehensive methodological development and benchmarking. Winning methods incorporate prior knowledge of drug-target interactions. Synergy is predicted with an accuracy matching biological replicates for >60% of combinations. However, 20% of drug combinations are poorly predicted by all methods. Genomic rationale for synergy predictions are identified, including ADAM17 inhibitor antagonism when combined with PIK3CB/D inhibition contrasting to synergy when combined with other PI3K-pathway inhibitors in PIK3CA mutant cells.-
dc.description.sponsorshipWe thank the Genomics of Drug Sensitivity in Cancer and COSMIC teams at the Wellcome Trust Sanger Institute for help with the preparation of the molecular data, Denes Turei for help with Omnipath, and Katjusa Koler for help with matching drug names across combination screens. We thank AstraZeneca for funding and provision of data to the DREAM Consortium to run the challenge, and funding from the European Union Horizon 2020 research (under grant agreement No 668858 PrECISE to J.S.R.), the Joint Research Center for Computational Biomedicine (which is partially funded by Bayer AG) to J.S.R., National Institute for Health Research (NIHR) Sheffield Biomedical Research Center, Premium Postdoctoral Fellowship Program of the Hungarian Academy of Sciences. M.G lab is supported by Wellcome Trust (102696 and 206194).-
dc.language.isoen-
dc.publisherNATURE PUBLISHING GROUP-
dc.rightsThe Author(s) 2019 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License-
dc.subject.otherMultidisciplinary Sciences-
dc.titleCommunity assessment to advance computational prediction of cancer drug combinations in a pharmacogenomic screen-
dc.typeJournal Contribution-
dc.identifier.volume10-
local.format.pages17-
local.bibliographicCitation.jcatA1-
dc.description.notes[Menden, Michael P.; Wang, Dennis; Bulusu, Krishna C.; Ghazoui, Zara; Tang, Eric K. Y.; Fornari, Chiara] AstraZeneca, IMED Biotech Unit, Oncol, Cambridge SG8 6EH, England. [Menden, Michael P.; Saez-Rodriguez, Julio] European Bioinformat Inst, European Mol Biol Lab, Cambridge CB10 1SD, England. [Wang, Dennis] Univ Sheffield, Sheffield Inst Translat Neurosci, Sheffield S10 2TN, S Yorkshire, England. [Mason, Mike J.; Yu, Thomas; Jang, In Sock; Neto, Elias Chaibub; Norman, Thea; Guinney, Justin; Bare, Christopher; Friend, Stephen; Truong, Amy] Sage Bionetworks, Seattle, WA 98121 USA. [Szalai, Bence; Cserzo, Miklos; Hunyady, Laszlo; Turu, Gabor] Semmelweis Univ, Fac Med, Dept Physiol, H-1085 Budapest, Hungary. [Szalai, Bence; Cserzo, Miklos; Hunyady, Laszlo; Turu, Gabor] Hungarian Acad Sci, Lab Mol Physiol, H-1085 Budapest, Hungary. [Szalai, Bence; Cserzo, Miklos; Hunyady, Laszlo; Turu, Gabor] Semmelweis Univ MTA SE, H-1085 Budapest, Hungary. [Szalai, Bence; Saez-Rodriguez, Julio] Rhein Westfal TH Aachen, Fac Med, Joint Res Ctr Computat Biomed, D-52062 Aachen, Germany. [Guan, Yuanfang] Univ Michigan, Dept Computat Med & Bioinformat, Ann Arbor, MI 48109 USA. [Kang, Jaewoo; Jeon, Minji; Chang, Hyeokyoon; Choi, Kwanghun; Kim, Sunkyu; Lee, Heewon; Park, Sungjoon; Yu, MinHwan] Korea Univ, Dept Comp Sci & Engn, Seoul 02841, South Korea. [Wolfinger, Russ] SAS Inst Inc, Cary, NC 27513 USA. [Nguyen, Tin] Univ Nevada, Dept Comp Sci & Engn, Reno, NV 89557 USA. [Zaslavskiy, Mikhail] Owkin Inc, Computat Biol, New York, NY 10022 USA. [Ahsen, Mehmet Eren; Vogel, Robert; Stolovitzky, Gustavo] IBM Thomas J Watson Res Ctr, Yorktown Hts, NY 10598 USA. [Garnett, Mathew J.] Wellcome Trust Sanger Inst, Hinxton CB10 1SA, England. [Di Veroli, Giovanni Y.] AstraZeneca, IMED Biotech Unit, Early Clin Dev, Cambridge SG8 6EH, England. [Fawell, Stephen; Dry, Jonathan R.] R&D Boston, AstraZeneca, IMED Biotech Unit, Oncol, Waltham, MA 02451 USA. [Stolovitzky, Gustavo] Icahn Sch Med Mt Sinai, Dept Genet & Genom Sci, New York, NY 10029 USA. [Menden, Michael P.] Helmholtz Zentrum MUnchen, Inst Computat Biol, German Res Ctr Environm Hlth, D-85764 Munich, Germany. [Saez-Rodriguez, Julio] Heidelberg Univ, Fac Med, Inst Computat Biomed, D-69120 Heidelberg, Germany. [Abante, Jordi; Karimi, Mostafa; Shen, Yang; Xie, Shuilian] Texas A&M Univ, Dept Elect & Comp Engn, College Stn, TX 77843 USA. [Abecassis, Barbara Schmitz; de Almeida, Mariana Pelicano; Ehrhart, Friederike; van Engelen, Bo; Evelo, Chris; Godynyuk, Lizzy; Low, Joshua; Malpartida, Ana Belen; Miller, Ryan A.; Muraru, Sebastian; Rieswijk, Linda; Schlichting, Moritz; Willighagen, Egon] BiGCaT NUTRIM Maastricht Univ, Dept Bioinformat, NL-6229 ER Maastricht, Netherlands. [Aben, Nanne; Bosdriesz, Evert; Bounova, Gergana; Kim, Yongsoo; Michaut, Magali; de Ruiter, Julian R.; Soufan, Othman; Vis, Daniel; Wessels, Lodewyk] Div Mol Carcinogenesis NKI, NL-1066 CX Amsterdam, Netherlands. [Aben, Nanne; Wessels, Lodewyk] Delft Univ Technol, Fac EEMCS, NL-2628 CD Delft, Netherlands. [Aghamirzaie, Delasa] Virginia Tech, Genet Bioinformat & Computat Biol, Blacksburg, VA 24061 USA. [Aittokallio, Tero; He, Liye; Khan, Suleiman Ali; Tang, Jing; Tanoli, Zia-ur-Rehman; Wennerberg, Krister] Univ Helsinki, Inst Mol Med Finland FIMM, FI-00014 Helsinki, Finland. [Akhtari, Farida S.; Jack, John; Motsinger-Reif, Alison; Roell, Kyle; Rotroff, Daniel] North Carolina State Univ, Bioinformat Res Ctr, Raleigh, NC 27695 USA. [Al-lazikani, Bissan; Antolin, Albert A.; Coker, Elizabeth; Mitsopoulos, Costas; Rodriguez-Gonzalvez, Carmen] Inst Canc Res, London SW3 6JB, England. 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local.publisher.placeLONDON-
local.type.refereedRefereed-
local.type.specifiedArticle-
local.bibliographicCitation.artnr2674-
dc.identifier.doi10.1038/s41467-019-09799-2-
dc.identifier.isi000471758500010-
item.contributorMenden, Michael P.-
item.contributorWang, Dennis-
item.contributorMason, Mike J.-
item.contributorSzalai, Bence-
item.contributorBulusu, Krishna C.-
item.contributorGuan, Yuanfang-
item.contributorYu, Thomas-
item.contributorKang, Jaewoo-
item.contributorJeon, Minji-
item.contributorWolfinger, Russ-
item.contributorNguyen, Tin-
item.contributorZaslavskiy, Mikhail-
item.contributorJang, In Sock-
item.contributorGhazoui, Zara-
item.contributorAhsen, Mehmet Eren-
item.contributorVogel, Robert-
item.contributorNeto, Elias Chaibub-
item.contributorNorman, Thea-
item.contributorTang, Eric K. Y.-
item.contributorGarnett, Mathew J.-
item.contributorDi Veroli, Giovanni Y.-
item.contributorFawell, Stephen-
item.contributorStolovitzky, Gustavo-
item.contributorGuinney, Justin-
item.contributorDry, Jonathan R.-
item.contributorSaez-Rodriguez, Julio-
item.contributorAbante, Jordi-
item.contributorAbecassis, Barbara Schmitz-
item.contributorAben, Nanne-
item.contributorAghamirzaie, Delasa-
item.contributorAittokallio, Tero-
item.contributorAkhtari, Farida S.-
item.contributorAl-lazikani, Bissan-
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item.contributorBajic, Vladimir-
item.contributorBall, Gordon-
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item.contributorCheng, Lijun-
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item.contributorCurtis, Christina-
item.contributorVan Daele, Dries-
item.contributorDang, Cuong C.-
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item.contributorDopazo, Joaquin-
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item.contributorvan Engelen, Bo-
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item.contributorde Esch, Iwan-
item.contributorEVELO, Chris-
item.contributorFalcao, Andre O.-
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item.contributorForoushani, Amir B. K.-
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item.contributorFriend, Stephen-
item.contributorFrigessi, Arnoldo-
item.contributorGao, Feng-
item.contributorGao, Xiaoting-
item.contributorGerold, Jeffrey M.-
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item.contributorGray, Harry-
item.contributorGrechkin, Maxim-
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item.contributorHaibe-Kains, Benjamin-
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item.contributorHe, Di-
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item.contributorHeath, Lenwood S.-
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item.contributorHu, Zhiyuan-
item.contributorHuang, Justin K.-
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item.contributorHwang, Woochang-
item.contributorHwang, Yongdeuk-
item.contributorIsayev, Olexandr-
item.contributorWalk, Oliver Bear Don't-
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item.contributorLewis, Richard-
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item.contributorLiley, James-
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item.contributorLiu, Yiyi-
item.contributorLopez, Yosvany-
item.contributorLow, Joshua-
item.contributorLysenko, Artem-
item.contributorMachado, Daniel-
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item.contributorMarchal, Kathleen-
item.contributorMarttinen, Pekka-
item.contributorMason, Daniel-
item.contributorMazaheri, Alireza-
item.contributorMehmood, Arfa-
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item.contributorMichaut, Magali-
item.contributorMiller, Ryan A.-
item.contributorMitsopoulos, Costas-
item.contributorModos, Dezso-
item.contributorVAN MOERBEKE, Marijke-
item.contributorMoo, Keagan-
item.contributorMotsinger-Reif, Alison-
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item.contributorAngel Pujana, Miguel-
item.contributorRamnarine, Ricardo-
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item.contributorReyal, Fabien-
item.contributorRichardson, Sylvia-
item.contributorRicketts, Camir-
item.contributorRieswijk, Linda-
item.contributorRocha, Miguel-
item.contributorRodriguez-Gonzalvez, Carmen-
item.contributorRoell, Kyle-
item.contributorRotroff, Daniel-
item.contributorde Ruiter, Julian R.-
item.contributorRukawa, Ploy-
item.contributorSadacca, Benjamin-
item.contributorSafikhani, Zhaleh-
item.contributorSafitri, Fita-
item.contributorSales-Pardo, Marta-
item.contributorSauer, Sebastian-
item.contributorSchlichting, Moritz-
item.contributorSeoane, Jose A.-
item.contributorSerra, Jordi-
item.contributorShang, Ming-Mei-
item.contributorSharma, Alok-
item.contributorSharma, Hari-
item.contributorShen, Yang-
item.contributorShiga, Motoki-
item.contributorShin, Moonshik-
item.contributorSHKEDY, Ziv-
item.contributorShopsowitz, Kevin-
item.contributorSinai, Sam-
item.contributorSkola, Dylan-
item.contributorSmirnov, Petr-
item.contributorSoerensen, Izel Fourie-
item.contributorSoerensen, Peter-
item.contributorSong, Je-Hoon-
item.contributorSong, Sang Ok-
item.contributorSoufan, Othman-
item.contributorSpitzmueller, Andreas-
item.contributorSteipe, Boris-
item.contributorSuphavilai, Chayaporn-
item.contributorTamayo, Sergio Pulido-
item.contributorTamborero, David-
item.contributorTang, Jing-
item.contributorTanoli, Zia-ur-Rehman-
item.contributorTarres-Deulofeu, Marc-
item.contributorTegner, Jesper-
item.contributorThommesen, Liv-
item.contributorTonekaboni, Seyed Ali Madani-
item.contributorTran, Hong-
item.contributorDE TROYER, Ewoud-
item.contributorTruong, Amy-
item.contributorTsunoda, Tatsuhiko-
item.contributorTuru, Gabor-
item.contributorTzeng, Guang-Yo-
item.contributorVerbeke, Lieven-
item.contributorVidela, Santiago-
item.contributorVis, Daniel-
item.contributorVoronkov, Andrey-
item.contributorVotis, Konstantinos-
item.contributorWang, Ashley-
item.contributorWang, Hong-Qiang Horace-
item.contributorWang, Po-Wei-
item.contributorWang, Sheng-
item.contributorWANG, Weixin-
item.contributorWang, Xiaochen-
item.contributorWang, Xin-
item.contributorWennerberg, Krister-
item.contributorWernisch, Lorenz-
item.contributorWessels, Lodewyk-
item.contributorvan Westen, Gerard J. P.-
item.contributorWesterman, Bart A.-
item.contributorWhite, Simon Richard-
item.contributorWillighagen, Egon-
item.contributorWurdinger, Tom-
item.contributorXie, Lei-
item.contributorXie, Shuilian-
item.contributorXu, Hua-
item.contributorYadav, Bhagwan-
item.contributorYau, Christopher-
item.contributorYeerna, Huwate-
item.contributorYin, Jia Wei-
item.contributorYu, Michael-
item.contributorYu, MinHwan-
item.contributorYun, So Jeong-
item.contributorZakharov, Alexey-
item.contributorZamichos, Alexandros-
item.contributorZanin, Massimiliano-
item.contributorZeng, Li-
item.contributorZenil, Hector-
item.contributorZhang, Frederick-
item.contributorZhang, Pengyue-
item.contributorZhang, Wei-
item.contributorZhao, Hongyu-
item.contributorZhao, Lan-
item.contributorZheng, Wenjin-
item.contributorZoufir, Azedine-
item.contributorZucknick, Manuela-
item.validationecoom 2020-
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