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http://hdl.handle.net/1942/29564
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DC Field | Value | Language |
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dc.contributor.author | LOUWIES, Tijs | - |
dc.contributor.author | INT PANIS, Luc | - |
dc.contributor.author | Alders, Toon | - |
dc.contributor.author | Bonné, Kim | - |
dc.contributor.author | Goswami, Nandu | - |
dc.contributor.author | NAWROT, Tim | - |
dc.contributor.author | DENDALE, Paul | - |
dc.contributor.author | DE BOEVER, Patrick | - |
dc.date.accessioned | 2019-09-23T14:12:37Z | - |
dc.date.available | 2019-09-23T14:12:37Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | MICROVASCULAR RESEARCH, 124, p. 25-29 | - |
dc.identifier.issn | 0026-2862 | - |
dc.identifier.uri | http://hdl.handle.net/1942/29564 | - |
dc.description.abstract | Background:Exercise-based rehabilitation improves general cardiovascularfitness. The impact on the micro-vascular system has been studied in less detail. We measured changes in retinal blood vessel diameters, as aproxy for microvascular reactivity, in cardiac patients and we assessed the impact of a rehabilitation program onretinal vessel diameters.Design:Cardiac patients (n = 78) and age-matched healthy controls (n = 32) performed an initial maximalendurance cycling test. Patients then participated in a 12-week rehabilitation program with additional en-durance tests being performed six and twelve weeks after the initial test.Methods:Fundus images were collected immediately before and 0, 5, 10, 15 and 30 min after the endurance test.Widths of retinal blood vessels, represented as Central Retinal Arteriolar/Venular Equivalent (CRAE/CRVE) werecalculated from the images.Results:At the start of the rehabilitation program, CRAE and CRVE values of the patients changed immediatelyafter the endurance test with respectively−1.90μm (95% CI:−3.58;−0.22) and−5.32μm (95% CI:−7.33;−3.30) compared to baseline values. In contrast, CRAE and CRVE values of healthy controls were respectivelyincreased [3.52μm (95% CI: 2.34; 4.69)] and decreased [−3.17μm (95% CI:−5.27;−1.07)]. After six andtwelve weeks, CRAE responses of patients immediately after endurance test increased respectively with 5.98μm(95% CI: 4.25; 7.71) and 4.44μm (95% CI: 3.18; 5.71). These responses were similar to the microvascularreactions observed in the control group.Conclusions:Arteriolar and venular retinal microvascular responses in cardiac patients were different from theones of healthy controls. Retinal microvascular response of cardiac patients improved during rehabilitation | - |
dc.description.sponsorship | Tijs Louwies was supported with a VITO PhD fellowship from 01/2012 to 12/2015 | - |
dc.language.iso | en | - |
dc.rights | 2019 Elsevier Inc. All rights reserved. | - |
dc.subject.other | Cardiac patients; Rehabilitation; Microvasculature; Retinal blood vessels | - |
dc.title | Microvascular reactivity in rehabilitating cardiac patients based on measurements of retinal blood vessel diameters. | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 29 | - |
dc.identifier.spage | 25 | - |
dc.identifier.volume | 124 | - |
local.bibliographicCitation.jcat | A1 | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.mvr.2019.02.006. | - |
dc.identifier.isi | 000466057200004 | - |
item.validation | ecoom 2020 | - |
item.fulltext | With Fulltext | - |
item.fullcitation | LOUWIES, Tijs; INT PANIS, Luc; Alders, Toon; Bonné, Kim; Goswami, Nandu; NAWROT, Tim; DENDALE, Paul & DE BOEVER, Patrick (2019) Microvascular reactivity in rehabilitating cardiac patients based on measurements of retinal blood vessel diameters.. In: MICROVASCULAR RESEARCH, 124, p. 25-29. | - |
item.accessRights | Restricted Access | - |
item.contributor | LOUWIES, Tijs | - |
item.contributor | INT PANIS, Luc | - |
item.contributor | Alders, Toon | - |
item.contributor | Bonné, Kim | - |
item.contributor | Goswami, Nandu | - |
item.contributor | NAWROT, Tim | - |
item.contributor | DENDALE, Paul | - |
item.contributor | DE BOEVER, Patrick | - |
crisitem.journal.issn | 0026-2862 | - |
crisitem.journal.eissn | 1095-9319 | - |
Appears in Collections: | Research publications |
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1-s2.0-S0026286218302991-main.pdf Restricted Access | Published version | 411.46 kB | Adobe PDF | View/Open Request a copy |
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