Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/29581
Title: | Longitudinal assessment of cerebral perfusion and vascular response to hypoventilation in a bigenic mouse model of Alzheimer's disease with amyloid and tau pathology | Authors: | GOVAERTS, Kristof Lechat, Benoit STRUYS, Tom Kremer, Anna Borghgraef, Peter Van Leuven, Fred Himmelreich, Uwe Dresselaers, Tom |
Issue Date: | 2019 | Publisher: | WILEY | Source: | NMR IN BIOMEDICINE, 32(2) (Art N° e4037) | Abstract: | Alzheimer's disease is the most common neurodegenerative disease, and many patients also present with vascular dysfunction. In this study, we aimed to assess cerebral blood flow (CBF) and cerebrovascular response (CVR) as early, pre-symptomatic (3 months of age), imaging markers in a bigenic model of Alzheimer's disease (APP.V717IxTau.P301L, biAT) and in the monogenic parental strains. We further developed our previously published combination of pulsed arterial spin labeling perfusion MRI and hypo-ventilation paradigm, which allows weaning of the mice from the ventilator. Furthermore, the commonly used isoflurane anesthesia induces vasodilation and is thereby inherently a vascular challenge. We therefore assessed perfusion differences in the mouse models under free-breathing isoflurane conditions. We report (i) that we can determine CBF and hypoventilation-based CVR under ketamine/midazolam anesthesia and wean mice from the ventilator, making it a valuable tool for assessment of CBF and CVR in mice, (ii) that biAT mice exhibit lower cortical CBF than wild-type mice at age 3 months, (iii) that CVR was increased in both biAT and APP.V717I mice but not in Tau.P301L mice, identifying the APP genotype as a strong influencer of brain CVR and (iv) that perfusion differences at baseline are masked by the widely used isoflurane anesthesia. | Notes: | [Govaerts, Kristof; Himmelreich, Uwe; Dresselaers, Tom] Katholieke Univ Leuven, Dept Imaging & Pathol, Biomed MRI MoSAIC, Leuven, Belgium. [Lechat, Benoit; Kremer, Anna; Borghgraef, Peter; Van Leuven, Fred] Katholieke Univ Leuven, Dept Human Genet, LEGTEGG, Leuven, Belgium. [Struys, Tom] Univ Hasselt, Morphol Res Grp, Biomed Res Inst, Hasselt, Belgium. | Keywords: | Alzheimer's disease; amyloid plaques; arterial spin labeling; cerebral perfusion; tau tangles;Biophysics; Radiology, Nuclear Medicine & Medical Imaging; Spectroscopy | Document URI: | http://hdl.handle.net/1942/29581 | ISSN: | 0952-3480 | e-ISSN: | 1099-1492 | DOI: | 10.1002/nbm.4037 | ISI #: | 000455099200011 | Rights: | 2018 John Wiley & Sons, Ltd | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
govaerts 1.pdf Restricted Access | Published version | 1.15 MB | Adobe PDF | View/Open Request a copy |
SCOPUSTM
Citations
3
checked on Sep 3, 2020
WEB OF SCIENCETM
Citations
10
checked on Sep 13, 2024
Page view(s)
126
checked on Sep 5, 2022
Download(s)
132
checked on Sep 5, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.