Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/29586
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | RAMAKERS, Gijs | - |
dc.contributor.author | WACKERS, Gideon | - |
dc.contributor.author | Trouillet, Vanessa | - |
dc.contributor.author | Welle, Alexander | - |
dc.contributor.author | WAGNER, Patrick | - |
dc.contributor.author | JUNKERS, Tanja | - |
dc.date.accessioned | 2019-09-26T14:12:55Z | - |
dc.date.available | 2019-09-26T14:12:55Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | MACROMOLECULES, 52(6), p. 2304-2313 | - |
dc.identifier.issn | 0024-9297 | - |
dc.identifier.uri | http://hdl.handle.net/1942/29586 | - |
dc.description.abstract | To be applicable to in vivo measuring, molecularly imprinted polymer (MIP) based sensors need to have high reproducibility, require miniaturization, and must be free of toxic materials (such as heavy metals). To address these requirements, a metal-free photo atom transfer radical polymerization (ATRP) grafting procedure is described using a pulsed UV laser as light source to create thin molecularly imprinted polymer (MIP) films (similar to 10 nm thickness) on a sensor surface. Analysis via X-ray photoelectron spectroscopy (XPS) and time-of-flight secondary ion mass spectrometry (ToF-SIMS) revealed the composition of the polymer film and the necessity for an excess of functional monomer to ensure its incorporation are demonstrated. MIP films were templated toward the target molecule histamine, for which in vivo studies can reveal unknown pathological pathways of inflammatory bowel diseases. By use of impedance spectroscopy, the biosensor surface is characterized in comparison to nonimprinted film grafts, and a high selectivity and sensitivity toward the target molecule are identified, revealing a histamine concentration limit of detection of 3.4 nM. | - |
dc.description.sponsorship | The authors are grateful for funding by the Research Foundation Flanders (FWO) via the project G.0B25.14N, and support from the Karlsruhe Micro Nano Facility (KMNF) is also kindly acknowledged. The authors wish to thank Mrs. Emely Bopp (IFG,KIT) for performing some TOF-SIMS experiments. Furthermore, the authors thank Prof. M. Wubbenhorst and Drs. P. Cornelis (both in KU Leuven) for making the impedance analyzer device available and for assistance in the evaluation of impedance spectroscopy data. | - |
dc.language.iso | en | - |
dc.publisher | AMER CHEMICAL SOC | - |
dc.rights | 2019 American Chemical Society | - |
dc.title | Laser-Grafted Molecularly Imprinted Polymers for the Detection of Histamine from Organocatalyzed Atom Transfer Radical Polymerization | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 2313 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 2304 | - |
dc.identifier.volume | 52 | - |
local.format.pages | 10 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Ramakers, Gijs; Junkers, Tanja] Univ Hasselt, Inst Mat Res IMO, Martelarenlaan 42, B-3500 Hasselt, Belgium. [Wackers, Gideon; Wagner, Patrick] Katholieke Univ Leuven, Dept Soft Matter & Biophys, Celestijnenlaan 200D, B-3001 Leuven, Belgium. [Trouillet, Vanessa] KIT, IAM, Hermann von Helmholtz Pl 1, D-76344 Eggenstein Leopoldshafen, Germany. [Welle, Alexander] KIT, Inst Funct Interfaces, Hermann von Helmholtz Pl 1, D-76344 Eggenstein Leopoldshafen, Germany. [Welle, Alexander] KNMF, Hermann von Helmholtz Pl 1, D-76344 Eggenstein Leopoldshafen, Germany. [Junkers, Tanja] Monash Univ, Sch Chem, Polymer React Design Grp, Rainforest Walk 19, Clayton, Vic 3800, Australia. | - |
local.publisher.place | WASHINGTON | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1021/acs.macromol.8b02339 | - |
dc.identifier.isi | 000462950300009 | - |
item.fullcitation | RAMAKERS, Gijs; WACKERS, Gideon; Trouillet, Vanessa; Welle, Alexander; WAGNER, Patrick & JUNKERS, Tanja (2019) Laser-Grafted Molecularly Imprinted Polymers for the Detection of Histamine from Organocatalyzed Atom Transfer Radical Polymerization. In: MACROMOLECULES, 52(6), p. 2304-2313. | - |
item.accessRights | Restricted Access | - |
item.fulltext | With Fulltext | - |
item.contributor | RAMAKERS, Gijs | - |
item.contributor | WACKERS, Gideon | - |
item.contributor | Trouillet, Vanessa | - |
item.contributor | Welle, Alexander | - |
item.contributor | WAGNER, Patrick | - |
item.contributor | JUNKERS, Tanja | - |
item.validation | ecoom 2020 | - |
crisitem.journal.issn | 0024-9297 | - |
crisitem.journal.eissn | 1520-5835 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
ramakers 1.pdf Restricted Access | Published version | 426.37 kB | Adobe PDF | View/Open Request a copy |
SCOPUSTM
Citations
4
checked on Sep 2, 2020
WEB OF SCIENCETM
Citations
25
checked on Aug 3, 2024
Page view(s)
106
checked on Sep 7, 2022
Download(s)
80
checked on Sep 7, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.