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http://hdl.handle.net/1942/29607
Title: | The challenges of peptidomics in complementing proteomics in a clinical context | Authors: | Maes, Evelyne Oeyen, Eline Boonen, Kurt Schildermans, Karin Mertens, Inge Pauwels, Patrick VALKENBORG, Dirk Baggerman, Geert |
Issue Date: | 2019 | Publisher: | WILEY | Source: | MASS SPECTROMETRY REVIEWS, 38(3), p. 253-264 | Abstract: | Naturally occurring peptides, including growth factors, hormones, and neurotransmitters, represent an important class of biomolecules and have crucial roles in human physiology. The study of these peptides in clinical samples is therefore as relevant as ever. Compared to more routine proteomics applications in clinical research, peptidomics research questions are more challenging and have special requirements with regard to sample handling, experimental design, and bioinformatics. In this review, we describe the issues that confront peptidomics in a clinical context. After these hurdles are (partially) overcome, peptidomics will be ready for a successful translation into medical practice. | Notes: | [Maes, Evelyne; Oeyen, Eline; Boonen, Kurt; Schildermans, Karin; Mertens, Inge; Valkenborg, Dirk; Baggerman, Geert] Flemish Inst Technol Res VITO, Mol, Belgium. [Maes, Evelyne; Oeyen, Eline; Boonen, Kurt; Schildermans, Karin; Mertens, Inge; Valkenborg, Dirk; Baggerman, Geert] Univ Antwerp, Ctr Prote, Antwerp, Belgium. [Maes, Evelyne] AgResearch Ltd, Food & Biobased Prod, Lincoln, New Zealand. [Pauwels, Patrick] Antwerp Univ Hosp, Dept Pathol, Mol Pathol Unit, Edegem, Belgium. [Valkenborg, Dirk] Hasselt Univ, Ctr Stat, Diepenbeek, Belgium. | Keywords: | peptidomics; biofluids; mass spectrometry; extraction; identification; neuropeptide;peptidomics; biofluids; mass spectrometry; extrac-tion; identification; neuropeptide | Document URI: | http://hdl.handle.net/1942/29607 | ISSN: | 0277-7037 | e-ISSN: | 1098-2787 | DOI: | 10.1002/mas.21581 | ISI #: | 000471702600003 | Rights: | 2018 by Wiley Periodicals, Inc. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2020 |
Appears in Collections: | Research publications |
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