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http://hdl.handle.net/1942/29619
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DC Field | Value | Language |
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dc.contributor.author | Takahashi, Kuniaki | - |
dc.contributor.author | Chichareon, Ply | - |
dc.contributor.author | Modolo, Rodrigo | - |
dc.contributor.author | Kogame, Norihiro | - |
dc.contributor.author | Chang, Chun Ching | - |
dc.contributor.author | Tomaniak, Mariusz | - |
dc.contributor.author | Moschovitis, Aris | - |
dc.contributor.author | Curzen, Nick | - |
dc.contributor.author | Haude, Michael | - |
dc.contributor.author | Jung, Werner | - |
dc.contributor.author | Holmvang, Lene | - |
dc.contributor.author | Garg, Scot | - |
dc.contributor.author | Tijssen, Jan G.P. | - |
dc.contributor.author | Wykrzykowska, Joanna J. | - |
dc.contributor.author | de Winter, Robbert J. | - |
dc.contributor.author | Hamm, Christian | - |
dc.contributor.author | Steg, Philippe Gabriel | - |
dc.contributor.author | Stoll, Hans-Peter | - |
dc.contributor.author | Onuma, Yoshinobu | - |
dc.contributor.author | Valgimigli, Marco | - |
dc.contributor.author | VRANCKX, Pascal | - |
dc.contributor.author | Windecker, Stephan | - |
dc.contributor.author | Serruys, Patrick W. | - |
dc.date.accessioned | 2019-10-01T08:04:46Z | - |
dc.date.available | 2019-10-01T08:04:46Z | - |
dc.date.issued | 2020 | - |
dc.identifier.citation | EuroIntervention, 16 (8), p. 634-644 | - |
dc.identifier.issn | 1774-024X | - |
dc.identifier.uri | http://hdl.handle.net/1942/29619 | - |
dc.description.abstract | AIMS: To evaluate the impact of a novel antiplatelet regimen in patients with increasing total stent length (TSL). METHODS AND RESULTS: This is a post-hoc analysis of the Global Leaders trial, a prospective, multi-centre, open-label, randomised trial, investigating the impact of the experimental strategy (one-month dual antiplatelet regimen [DAPT] followed by 23-month ticagrelor monotherapy) versus the reference regimen (12-month DAPT followed by 12-month aspirin monotherapy) in patients with Biolimus A9-eluting stent (BES). The primary endpoint was the composite of the all-cause death and new Q-wave myocardial infarction (MI), and the secondary endpoint was Bleeding Academic Research Consortium (BARC) type 3 or 5 bleeding at two years. To investigate the association between total stent length and outcomes, groups were compared in quartiles according to TSL, and the fourth quartile group was at significantly higher ischemic risk at two years. In that stratum (TSL≥ 46mm), the experimental strategy significantly reduced the risk of the primary endpoint (hazard ratio [HR]:0.67; 95% confidence interval [CI]:0.49-0.90; Pinteraction=0.043), while demonstrating a similar risk of BARC type 3 or 5 bleeding (HR:0.99; 95% CI:0.66-1.49; Pinteraction =0.975). CONCLUSIONS: Ticagrelor monotherapy potentially could balance ischemic and bleeding risks, thereby achieving a net clinical benefit in patients with TSL≥ 46 mm with BES. | - |
dc.description.sponsorship | The GLOBAL LEADERS trial was supported by resources from AstraZeneca, Biosensors, and The Medicines Company | - |
dc.language.iso | en | - |
dc.publisher | EUROPA EDITION | - |
dc.rights | Europa Digital & Publishing 2020. All rights reserved. | - |
dc.subject.other | ACS/NSTE-ACS | - |
dc.subject.other | adjunctive pharmacotherapy | - |
dc.subject.other | drug-eluting stent | - |
dc.subject.other | stable angina | - |
dc.title | Impact of Ticagrelor Monotherapy on Two-Year Clinical Outcomes in Patients with Long Stenting: A Post Hoc Analysis of the Global Leaders Trial. | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 644 | - |
dc.identifier.issue | 8 | - |
dc.identifier.spage | 634 | - |
dc.identifier.volume | 16 | - |
local.bibliographicCitation.jcat | A1 | - |
local.publisher.place | 19 ALLEES JEAN JAURES B P 61508, TOULOUSE CEDEX 6, 31015, FRANCE | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.4244/EIJ-D-19-00498 | - |
dc.identifier.pmid | 31498113 | - |
dc.identifier.isi | WOS:000582258100002 | - |
dc.identifier.eissn | 1969-6213 | - |
local.provider.type | Web of Science | - |
local.uhasselt.uhpub | yes | - |
local.uhasselt.international | yes | - |
item.accessRights | Restricted Access | - |
item.contributor | Takahashi, Kuniaki | - |
item.contributor | Chichareon, Ply | - |
item.contributor | Modolo, Rodrigo | - |
item.contributor | Kogame, Norihiro | - |
item.contributor | Chang, Chun Ching | - |
item.contributor | Tomaniak, Mariusz | - |
item.contributor | Moschovitis, Aris | - |
item.contributor | Curzen, Nick | - |
item.contributor | Haude, Michael | - |
item.contributor | Jung, Werner | - |
item.contributor | Holmvang, Lene | - |
item.contributor | Garg, Scot | - |
item.contributor | Tijssen, Jan G.P. | - |
item.contributor | Wykrzykowska, Joanna J. | - |
item.contributor | de Winter, Robbert J. | - |
item.contributor | Hamm, Christian | - |
item.contributor | Steg, Philippe Gabriel | - |
item.contributor | Stoll, Hans-Peter | - |
item.contributor | Onuma, Yoshinobu | - |
item.contributor | Valgimigli, Marco | - |
item.contributor | VRANCKX, Pascal | - |
item.contributor | Windecker, Stephan | - |
item.contributor | Serruys, Patrick W. | - |
item.fullcitation | Takahashi, Kuniaki; Chichareon, Ply; Modolo, Rodrigo; Kogame, Norihiro; Chang, Chun Ching; Tomaniak, Mariusz; Moschovitis, Aris; Curzen, Nick; Haude, Michael; Jung, Werner; Holmvang, Lene; Garg, Scot; Tijssen, Jan G.P.; Wykrzykowska, Joanna J.; de Winter, Robbert J.; Hamm, Christian; Steg, Philippe Gabriel; Stoll, Hans-Peter; Onuma, Yoshinobu; Valgimigli, Marco; VRANCKX, Pascal; Windecker, Stephan & Serruys, Patrick W. (2020) Impact of Ticagrelor Monotherapy on Two-Year Clinical Outcomes in Patients with Long Stenting: A Post Hoc Analysis of the Global Leaders Trial.. In: EuroIntervention, 16 (8), p. 634-644. | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2021 | - |
crisitem.journal.issn | 1774-024X | - |
crisitem.journal.eissn | 1969-6213 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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EuroIntervention2.pdf Restricted Access | Published version | 1.66 MB | Adobe PDF | View/Open Request a copy |
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