Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/29638
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | SMOLDERS, Sophie | - |
dc.contributor.author | KESSELS, Sofie | - |
dc.contributor.author | VANGANSEWINKEL, Tim | - |
dc.contributor.author | RIGO, Jean-Michel | - |
dc.contributor.author | Legendre, Pascal | - |
dc.contributor.author | BRONE, Bert | - |
dc.date.accessioned | 2019-10-01T13:55:13Z | - |
dc.date.available | 2019-10-01T13:55:13Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | PROGRESS IN NEUROBIOLOGY, 178, p. 60-80 (Art N° 101612) | - |
dc.identifier.issn | 0301-0082 | - |
dc.identifier.uri | http://hdl.handle.net/1942/29638 | - |
dc.description.abstract | In the last decade, tremendous progress has been made in understanding the biology of microglia – i.e. thefascinating immigrated resident immune cell population of the central nervous system (CNS). Recent literaturereviews have largely dealt with the plentiful functions of microglia in CNS homeostasis, development and pa-thology, and the influences of sex and the microbiome. In this review, the intriguing aspect of their physicalplasticity during CNS development will get specific attention. Microglia move around (mobility) and reshapetheir processes (motility). Microglial migration into and inside the CNS is most prominent throughout devel-opment and consequently most of the data described in this review concern mobility and motility in thechangingenvironmentofthedevelopingbrain.Here,wefirstdefinemicrogliabasedontheirhighlyspecializedage-andregion-dependentgeneexpressionsignatureandassociatedfunctionalheterogeneity.Next,wedescribetheirorigin,themigrationrouteofimmaturemicroglialcellstowardstheCNS,themechanismsunderlyingtheirinvasion of the CNS, and their spatiotemporal localization and surveying behaviour inside the developing CNS.These processes are dependent on microglial mobility and motility which are determined by the micro-environmentoftheCNS.Therefore,wefurtherzoominonthechangingenvironmentduringCNSdevelopment.We elaborate on the extracellular matrix and the respective integrin receptors on microglia and we discuss thepurinergic and molecular signalling in microglial mobility. In the last section, we discuss the physiological andpathological functions of microglia in which mobility and motility are involved to stress the importance ofmicroglial ‘movement’ | - |
dc.description.sponsorship | We thank Edna Stewart for reading and correcting this manuscript. Work was supported by grants from Hasselt University (BOF16NI04 and BOF ulg-uhasselt grant), Sint Vincentius Autism research grant, Research Foundation Flanders (FWO 1521619N and 1518419N), and Rotary Belgium (Espoir en Tête – Hoofdzaak er is Hoop). This work is supported by AFM-Téléthon, Grant/Award Number: 1856420445. | - |
dc.language.iso | en | - |
dc.rights | 2019 Elsevier Ltd. All rights reserved | - |
dc.subject.other | Microglia; CNSM; igration; Motility; Phagocytosis; Molecular signalling | - |
dc.title | Microglia: Brain cells on the move | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 80 | - |
dc.identifier.spage | 60 | - |
dc.identifier.volume | 178 | - |
local.bibliographicCitation.jcat | A1 | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 101612 | - |
dc.identifier.doi | 10.1016/j.pneurobio.2019.04.001 | - |
dc.identifier.isi | 000474321500003 | - |
item.contributor | SMOLDERS, Sophie | - |
item.contributor | KESSELS, Sofie | - |
item.contributor | VANGANSEWINKEL, Tim | - |
item.contributor | RIGO, Jean-Michel | - |
item.contributor | Legendre, Pascal | - |
item.contributor | BRONE, Bert | - |
item.validation | ecoom 2020 | - |
item.fulltext | With Fulltext | - |
item.accessRights | Open Access | - |
item.fullcitation | SMOLDERS, Sophie; KESSELS, Sofie; VANGANSEWINKEL, Tim; RIGO, Jean-Michel; Legendre, Pascal & BRONE, Bert (2019) Microglia: Brain cells on the move. In: PROGRESS IN NEUROBIOLOGY, 178, p. 60-80 (Art N° 101612). | - |
crisitem.journal.issn | 0301-0082 | - |
crisitem.journal.eissn | 1873-5118 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
Progress in Neurobiology_Microglia brain cells on the move_Author version.pdf | Peer-reviewed author version | 2.25 MB | Adobe PDF | View/Open |
Publication PoNB Microglia brain cells on the move.pdf Restricted Access | Published version | 3.93 MB | Adobe PDF | View/Open Request a copy |
SCOPUSTM
Citations
11
checked on Sep 3, 2020
WEB OF SCIENCETM
Citations
66
checked on Oct 13, 2024
Page view(s)
148
checked on Jul 19, 2022
Download(s)
376
checked on Jul 19, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.