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http://hdl.handle.net/1942/29728
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DC Field | Value | Language |
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dc.contributor.author | VRIENS, Annette | - |
dc.contributor.author | NAWROT, Tim | - |
dc.contributor.author | JANSSEN, Bram | - |
dc.contributor.author | Baeyens, Willy | - |
dc.contributor.author | BRUCKERS, Liesbeth | - |
dc.contributor.author | Covaci, Adrian | - |
dc.contributor.author | De Craemer, Sam | - |
dc.contributor.author | De Henauw, Stefaan | - |
dc.contributor.author | Den Hond, Elly | - |
dc.contributor.author | Loots, Ilse | - |
dc.contributor.author | Nelen, Vera | - |
dc.contributor.author | Schettgen, Thomas | - |
dc.contributor.author | Schoeters, Greet | - |
dc.contributor.author | MARTENS, Dries | - |
dc.contributor.author | PLUSQUIN, Michelle | - |
dc.date.accessioned | 2019-10-14T12:02:26Z | - |
dc.date.available | 2019-10-14T12:02:26Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Environmental science & technology, 53(10), p. 5966-5976 | - |
dc.identifier.issn | 0013-936X | - |
dc.identifier.uri | http://hdl.handle.net/1942/29728 | - |
dc.description.abstract | Mitochondrial DNA (mtDNA) content and telomere length are putative aging biomarkers and are sensitive to environmental stressors, including pollutants. Our objective was to identify, from a set of environmental exposures, which exposure is associated with leukocyte mtDNA content and telomere length in adults. This study includes 175 adults from 50 to 65 years old from the crosssectional Flemish Environment and Health study, of whom leukocyte telomere length and mtDNA content were determined using qPCR. The levels of exposure of seven metals, 11 organohalogens, and four perfluorinated compounds (PFHxS, PFNA, PFOA, PFOS) were measured. We performed sparse partial least-squares regression analyses followed by ordinary least-squares regression to assess the multipollutant associations. While accounting for possible confounders and coexposures, we identified that urinary cadmium (6.52%, 95% confidence interval, 1.06, 12.28), serum hexachlorobenzene (2.89%, 018, 5.68), and perfluorooctanesulfonic acid (11.38%, 5.97, 17.08) exposure were positively associated (p < 0.05) with mtDNA content, while urinary copper (−9.88%, −14.82, −4.66) and serum perfluorohexanesulfonic acid (−4.75%, −8.79, −0.54) exposure were inversely associated with mtDNA content. Urinary antimony (2.69%, 0.45, 4.99) and mercury (1.91%, 0.42, 3.43) exposure were positively associated with leukocyte telomere length, while urinary copper (−3.52%, −6.60, −0.34) and serum perfluorooctanesulfonic acid (−3.64%, −6.60, −0.60) showed an inverse association. Our findings support the hypothesis that environmental pollutants interact with molecular hallmarks of aging. | - |
dc.description.sponsorship | The FLEHS studies were carried out by the Flemish Center of Expertise on Environment and Health. The studies of the Center were commissioned, financed, and steered by the Ministry of the Flemish Community. Measurements of mitochondrial DNA content and telomere length were supported by the EU Program “Ideas” (ERC-2012-StG 310898) and by the Flemish Scientific Fund (FWO G.0.873.11.N.10). A.V. is financially supported by Environmental Science & Technology Article DOI: 10.1021/acs.est.8b07141 Environ. Sci. Technol. 2019, 53, 5966−5976 5973 the University Research Fund (Bijzonder Onderzoeksfonds Universiteit Hasselt). B.G.J. holds a postdoc position of the Research Foundation Flanders (FWO). | - |
dc.language.iso | en | - |
dc.rights | 2019 American Chemical Society | - |
dc.title | Exposure to Environmental Pollutants and Their Association with Biomarkers of Aging: A Multipollutant Approach | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 5976 | - |
dc.identifier.issue | 10 | - |
dc.identifier.spage | 5966 | - |
dc.identifier.volume | 53 | - |
local.bibliographicCitation.jcat | A1 | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1021/acs.est.8b07141 | - |
dc.identifier.isi | 000469288100048 | - |
item.contributor | VRIENS, Annette | - |
item.contributor | NAWROT, Tim | - |
item.contributor | JANSSEN, Bram | - |
item.contributor | Baeyens, Willy | - |
item.contributor | BRUCKERS, Liesbeth | - |
item.contributor | Covaci, Adrian | - |
item.contributor | De Craemer, Sam | - |
item.contributor | De Henauw, Stefaan | - |
item.contributor | Den Hond, Elly | - |
item.contributor | Loots, Ilse | - |
item.contributor | Nelen, Vera | - |
item.contributor | Schettgen, Thomas | - |
item.contributor | Schoeters, Greet | - |
item.contributor | MARTENS, Dries | - |
item.contributor | PLUSQUIN, Michelle | - |
item.fullcitation | VRIENS, Annette; NAWROT, Tim; JANSSEN, Bram; Baeyens, Willy; BRUCKERS, Liesbeth; Covaci, Adrian; De Craemer, Sam; De Henauw, Stefaan; Den Hond, Elly; Loots, Ilse; Nelen, Vera; Schettgen, Thomas; Schoeters, Greet; MARTENS, Dries & PLUSQUIN, Michelle (2019) Exposure to Environmental Pollutants and Their Association with Biomarkers of Aging: A Multipollutant Approach. In: Environmental science & technology, 53(10), p. 5966-5976. | - |
item.accessRights | Restricted Access | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2020 | - |
crisitem.journal.issn | 0013-936X | - |
crisitem.journal.eissn | 1520-5851 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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acs.est.8b07141.pdf Restricted Access | Published version | 1.22 MB | Adobe PDF | View/Open Request a copy |
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