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Title: Fatigue is highly prevalent in patients with COPD and correlates poorly with the degree of airflow limitation
Authors: Goërtz, Yvonne M. J.
SPRUIT, Martijn A. 
Van 't Hul, Alex J.
Peters, Jeannette B.
VAN HERCK, Maarten 
Nakken, Nienke
Djamin, Remco S.
BURTIN, Chris 
Thong, Melissa S. Y.
Coors, Arnold
Meertens-Kerris, Yvonne
Wouters, Emiel F. M.
Prins, Judith B.
Franssen, Frits M. E.
Muris, Jean W. M.
Vanfleteren, Lowie E.G.W.
Sprangers, Mirjam A. G.
Janssen, Daisy J. A.
Vercoulen, Jan H.
Issue Date: 2019
Source: Therapeutic Advances in Respiratory Disease, 13, p. 1-13 (Art N° 1753466619878128)
Abstract: Background: The objective of this study was to compare fatigue levels between subjects with and without COPD, and to investigate the relationship between fatigue, demographics, clinical features and disease severity. Methods: A total of 1290 patients with COPD [age 65 ± 9 years, 61% male, forced expiratory volume in 1 s (FEV1) 56 ± 19% predicted] and 199 subjects without COPD (age 63 ± 9 years, 51% male, FEV1 112 ± 21% predicted) were assessed for fatigue (Checklist Individual Strength-Fatigue), demographics, clinical features and disease severity. Results: Patients with COPD had a higher mean fatigue score, and a higher proportion of severe fatigue (CIS-Fatigue score 35 ± 12 versus 21 ± 11 points, p < 0.001; 49 versus 10%, p < 0.001). Fatigue was significantly, but poorly, associated with the degree of airflow limitation [FEV1 (% predicted) Spearman correlation coefficient = −0.08, p = 0.006]. Multiple regression indicated that 30% of the variance in fatigue was explained by the predictor variables. Conclusions: Severe fatigue is prevalent in half of the patients with COPD, and correlates poorly with the degree of airflow limitation. Future studies are needed to better understand the physical, psychological, behavioural, and systemic factors that precipitate or perpetuate fatigue in COPD.
Notes: Goertz, YMJ (reprint author), Ciro, Ctr Expertise Chron Organ Failure, Dept Res & Educ, NL-6085 NM Horn, Netherlands.
Keywords: airway obstruction; chronic obstructive pulmonary disease; fatigue
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ISSN: 1753-4658
e-ISSN: 1753-4666
DOI: 10.1177/1753466619878128
ISI #: 000487954300001
Rights: The Author(s), 2019. Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (
Category: A1
Type: Journal Contribution
Validations: ecoom 2020
Appears in Collections:Research publications

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