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http://hdl.handle.net/1942/29809
Title: | Ambient black carbon particles reach the fetal side of human placenta | Authors: | BOVE, Hannelore BONGAERTS, Eva SLENDERS, Eli BIJNENS, Esmee SAENEN, Nelly GYSELAERS, Wilfried Van Eyken, Peter PLUSQUIN, Michelle Roeffaers, Maarten B. J. AMELOOT, Marcel NAWROT, Tim |
Issue Date: | 2019 | Publisher: | NATURE PUBLISHING GROUP | Source: | NATURE COMMUNICATIONS, 10 (Art N° 3866) | Abstract: | Particle transfer across the placenta has been suggested but to date, no direct evidence in real-life, human context exists. Here we report the presence of black carbon (BC) particles as part of combustion-derived particulate matter in human placentae using white-light generation under femtosecond pulsed illumination. BC is identified in all screened placentae, with an average (SD) particle count of 0.95 x 10(4) (0.66 x 10(4)) and 2.09 x 10(4) (0.9 x 10(4)) particles per mm(3) for low and high exposed mothers, respectively. Furthermore, the placental BC load is positively associated with mothers' residential BC exposure during pregnancy (0.63-2.42 lug per m(3)). Our finding that BC particles accumulate on the fetal side of the placenta suggests that ambient particulates could be transported towards the fetus and represents a potential mechanism explaining the detrimental health effects of pollution from early life onwards. | Notes: | [Bove, Hannelore; Bongaerts, Eva; Bijnens, Esmee M.; Saenen, Nelly D.; Plusquin, Michelle; Nawrot, Tim S.] Hasselt Univ, Ctr Environm Sci, Agoralaan Bldg D, B-3590 Diepenbeek, Belgium. [Bove, Hannelore; Slenders, Eli; Ameloot, Marcel] Hasselt Univ, Biomed Res Inst, Agoralaan Bldg C, B-3590 Diepenbeek, Belgium. [Bove, Hannelore; Roeffaers, Maarten B. J.] Katholieke Univ Leuven, Ctr Surface Chem & Catalysis, Celestijnenlaan 200F Box 2461, B-3001 Leuven, Belgium. [Gyselaers, Wilfried; Van Eyken, Peter] East Limburg Hosp, Dept Obstet, Schiepse Bos 6, B-3600 Genk, Belgium. [Nawrot, Tim S.] Katholieke Univ Leuven, Dept Publ Hlth & Primary Care, Herestr 49 Box 706, B-3000 Leuven, Belgium. | Document URI: | http://hdl.handle.net/1942/29809 | e-ISSN: | 2041-1723 | DOI: | 10.1038/s41467-019-11654-3 | ISI #: | 000486138200001 | Rights: | Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2020 |
Appears in Collections: | Research publications |
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