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Title: | Impact of Weight Loss Strategies on Obesity-Induced DNA Damage | Authors: | Setayesh, Tahereh Misik, Miroslav LANGIE, Sabine GODSCHALK, Roger Waldherr, Monika Bauer, Thomas Leitner, Sabine Bichler, Christoph Prager, Gerhard Krupitza, Georg Haslberger, Alexander Knasmueller, Siegfried |
Issue Date: | 2019 | Publisher: | WILEY | Source: | MOLECULAR NUTRITION & FOOD RESEARCH, 63(17) (Art N° 1900045) | Abstract: | Scope Obesity causes DNA damage, which is causally related to several disorders including cancer, infertility, and cognitive dysfunctions. The aim of this study is to investigate whether weight loss improves the integrity of the genetic material. Methods and Results Overweight mice are fed ad libitum either with a Western diet (WD), with a 40% caloric restricted WD, or with a high carbohydrate low protein (HCLP) diet. Caloric restriction and also the HCLP diet lead to ca. 30% weight loss, which is paralleled by decreased DNA damage ("comet" formation) and oxidative damage of purines in inner organs, additionally the activity of nucleotide excision repair increased. The effects are more pronounced in animals that have received the HCLP chow. Results of biochemical analyses indicate that the reduction of DNA damage is associated with a decrease of pro-inflammatory cytokines and lower insulin levels. Conclusion The study indicates that weight loss may prevent obesity-associated adverse health effects due to reduction of overall DNA damage. | Notes: | [Setayesh, Tahereh; Misik, Miroslav; Waldherr, Monika; Bauer, Thomas; Knasmueller, Siegfried] Med Univ Vienna, Inst Canc Res, Dept Internal Med 1, Vienna, Austria. [Langie, Sabine A. S.] VITO Hlth, Mol, Belgium. [Langie, Sabine A. S.] Hasselt Univ, Ctr Environm Sci, Hasselt, Belgium. [Godschalk, Roger] Maastricht Univ, Sch Nutr Toxicol & Metab NUTRIM, Dept Pharmacol & Toxicol, Maastricht, Netherlands. [Leitner, Sabine] Med Univ Vienna, Dept Biomed Imaging & Image Guided Therapy, Vienna, Austria. [Bichler, Christoph; Prager, Gerhard] Med Univ Vienna, Dept Surg, Div Gen Surg, Sect Endocrine Surg, Vienna, Austria. [Krupitza, Georg] Med Univ Vienna, Clin Inst Pathol, Vienna, Austria. [Haslberger, Alexander] Univ Vienna, Dept Nutr Sci, Vienna, Austria. | Keywords: | DNA damage; DNA repair; inflammation; weight loss; Western diet | Document URI: | http://hdl.handle.net/1942/29841 | ISSN: | 1613-4125 | e-ISSN: | 1613-4133 | DOI: | 10.1002/mnfr.201900045 | ISI #: | 000485931500008 | Rights: | 2019 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2020 |
Appears in Collections: | Research publications |
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