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http://hdl.handle.net/1942/29869
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DC Field | Value | Language |
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dc.contributor.author | Bourgeois, S. | - |
dc.contributor.author | Mulkay, J. P. | - |
dc.contributor.author | Lasser, L. | - |
dc.contributor.author | ROBAEYS, Geert | - |
dc.contributor.author | Bastens, B. | - |
dc.contributor.author | Delwaide, J. | - |
dc.contributor.author | Pollet, S. | - |
dc.contributor.author | Van den Enden, M. | - |
dc.date.accessioned | 2019-10-29T11:27:40Z | - |
dc.date.available | 2019-10-29T11:27:40Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | ACTA GASTRO-ENTEROLOGICA BELGICA, 82(1), p. 43-52 | - |
dc.identifier.issn | 1784-3227 | - |
dc.identifier.uri | http://hdl.handle.net/1942/29869 | - |
dc.description.abstract | Background and Study Aims : Direct-acting antivirals provide interferon-free treatments for chronic hepatitis C (CHC) virus infection. In Belgium, in 2016, access to these agents was limited to patients with advanced liver fibrosis stages F3 and F4. This study is the first to describe Belgium's patient population ineligible for interferon-free treatment. Patients and Methods : This was an observational, cross-sectional, multicentre study that enrolled adult patients with CHC ineligible for interferon-free treatment. Patient data recorded at a single visit included demographic data, disease characteristics, comorbidities, co-medications, treatment status, and laboratory data. Results : Three hundred and three patients from 16 centres in Belgium were included in the statistical analysis. On average, patients were aged 53.5 years and 50.2% were women; 94.1% had health insurance and 99.0% resided in Belgium. The current hepatitis C virus (HCV) infection was the first infection for 96.0% of patients and the mean time since infection was 20.0 years. Liver fibrosis stage was F0 for 23.7%, F0/F1 or F1 for 38.3%, F1/F2 or F2 for 25.8%, F3 for 7.1%, and F4 for 5.1% of patients; 28.4% of patients were CHC treatment-experienced. The main reason for ineligibility for interferon-free treatment was lack of reimbursement (84.8%). Other reasons included no treatment urgency or medical decision to wait (27.1%), waiting for future treatment option (8.3%), and no social insurance coverage (3.6%). Conclusions : This study provides recent data on the CHC patient population and disease characteristics in Belgium that could help medical communities and government agencies manage CHC disease burden. | - |
dc.description.sponsorship | The design, study conduct, and financial support for the study were provided by AbbVie Belgium NV/SA. AbbVie participated in the interpretation of data, review, and approval of the publication. Keyrus Biopharma provided medical writing support and Data Investigation Company Europe (DICE) NV/SA provided data management and statistical analysis support. The financial support for these services was provided by AbbVie. | - |
dc.language.iso | en | - |
dc.publisher | UNIV CATHOLIQUE LOUVAIN-UCL | - |
dc.subject.other | Gastroenterology & Hepatology | - |
dc.subject.other | Belgium; chronic hepatitis C; direct antiviral agent; interferon-free regimen; observational | - |
dc.title | A multicentre, observational study on demographic and disease characteristics of patients seeking care for chronic hepatitis C in Belgium in 2016 | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 52 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 43 | - |
dc.identifier.volume | 82 | - |
local.format.pages | 10 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Bourgeois, S.] ZNA Gastroteam, Antwerp, Belgium. [Mulkay, J. P.] CHU St Pierre, Brussels, Belgium. [Lasser, L.] CHU Brugmann, Brussels, Belgium. [Robaeys, G.] Ziekenhuis Oost Limburg, Dept Gastroenterol & Hepatol, Genk, Belgium. [Robaeys, G.] Univ Hasselt, Fac Med & Life Sci, Hasselt, Belgium. [Bastens, B.] CHC Liege, Liege, Belgium. [Delwaide, J.] CHU Sart Tilman, Liege, Belgium. [Pollet, S.; Van den Enden, M.] AbbVie SA NV, Ave Einstein 14, B-1300 Wavre, Belgium. | - |
local.publisher.place | BRUSSELS | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.isi | 000473740400008 | - |
item.fullcitation | Bourgeois, S.; Mulkay, J. P.; Lasser, L.; ROBAEYS, Geert; Bastens, B.; Delwaide, J.; Pollet, S. & Van den Enden, M. (2019) A multicentre, observational study on demographic and disease characteristics of patients seeking care for chronic hepatitis C in Belgium in 2016. In: ACTA GASTRO-ENTEROLOGICA BELGICA, 82(1), p. 43-52. | - |
item.validation | ecoom 2020 | - |
item.contributor | Bourgeois, S. | - |
item.contributor | Mulkay, J. P. | - |
item.contributor | Lasser, L. | - |
item.contributor | ROBAEYS, Geert | - |
item.contributor | Bastens, B. | - |
item.contributor | Delwaide, J. | - |
item.contributor | Pollet, S. | - |
item.contributor | Van den Enden, M. | - |
item.accessRights | Closed Access | - |
item.fulltext | No Fulltext | - |
crisitem.journal.issn | 1784-3227 | - |
crisitem.journal.eissn | 1784-3227 | - |
Appears in Collections: | Research publications |
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