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http://hdl.handle.net/1942/29885
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DC Field | Value | Language |
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dc.contributor.author | Li, Zhiling | - |
dc.contributor.author | Hao, Marlene M. | - |
dc.contributor.author | Van den Haute, Chris | - |
dc.contributor.author | Baekelandt, Veerle | - |
dc.contributor.author | BOESMANS, Werend | - |
dc.contributor.author | Vanden Berghe, Pieter | - |
dc.date.accessioned | 2019-10-31T10:04:17Z | - |
dc.date.available | 2019-10-31T10:04:17Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | eLife, 8 (Art N° e42914) | - |
dc.identifier.issn | 2050-084X | - |
dc.identifier.uri | http://hdl.handle.net/1942/29885 | - |
dc.description.abstract | The enteric nervous system controls a variety of gastrointestinal functions including intestinal motility. The minimal neuronal circuit necessary to direct peristalsis is well-characterized but several intestinal regions display also other motility patterns for which the underlying circuits and connectivity schemes that coordinate the transition between those patterns are poorly understood. We investigated whether in regions with a richer palette of motility patterns, the underlying nerve circuits reflect this complexity. Using Ca2+ imaging, we determined the location and response fingerprint of large populations of enteric neurons upon focal network stimulation. Complemented by neuronal tracing and volumetric reconstructions of synaptic contacts, this shows that the multifunctional proximal colon requires specific additional circuit components as compared to the distal colon, where peristalsis is the predominant motility pattern. Our study reveals that motility control is hard-wired in the enteric neural networks and that circuit complexity matches the motor pattern portfolio of specific intestinal regions. | - |
dc.description.sponsorship | Chinese Scholarship Council 201408370078; National Health and Medical Research Council APP1655567; Fonds Wetenschappelijk Onderzoek 12G1214N; KU Leuven C32/15/031; Fonds Wetenschappelijk Onderzoek SBO/S006617N; Fonds Wetenschappelijk Onderzoek G.0921.15; Hercules Foundation AKUL/15/37; Hercules Foundation AKUL/11/37; Hercules Foundation AKUL/13/37; Belgian National Fund for Scientific Research G.0921.15 SBO/S006617N; Instituut voor Innovatie door Wetenschap en Technologie SBO/130065 | - |
dc.language.iso | en | - |
dc.rights | Open access. Copyright Li et al. This article is distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use and redistribution provided that the original author and source are credited | - |
dc.title | Regional complexity in enteric neuron wiring reflects diversity of motility patterns in the mouse large intestine | - |
dc.type | Journal Contribution | - |
dc.identifier.volume | 8 | - |
local.bibliographicCitation.jcat | A1 | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | e42914 | - |
dc.identifier.doi | 10.7554/eLife.42914 | - |
dc.identifier.isi | 000459813900001 | - |
item.fullcitation | Li, Zhiling; Hao, Marlene M.; Van den Haute, Chris; Baekelandt, Veerle; BOESMANS, Werend & Vanden Berghe, Pieter (2019) Regional complexity in enteric neuron wiring reflects diversity of motility patterns in the mouse large intestine. In: eLife, 8 (Art N° e42914). | - |
item.accessRights | Open Access | - |
item.contributor | Li, Zhiling | - |
item.contributor | Hao, Marlene M. | - |
item.contributor | Van den Haute, Chris | - |
item.contributor | Baekelandt, Veerle | - |
item.contributor | BOESMANS, Werend | - |
item.contributor | Vanden Berghe, Pieter | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2020 | - |
crisitem.journal.issn | 2050-084X | - |
crisitem.journal.eissn | 2050-084X | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
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elife-42914-v2.pdf | Published version | 7.78 MB | Adobe PDF | View/Open |
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