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Title: | Mast cells as protectors of health | Authors: | Dudeck, Anne Koeberle, Martin Goldmann, Oliver Meyer, Nicole Dudeck, Jan LEMMENS, Stefanie Rohde, Manfred Roldan, Nestor Gonzalez Dietze-Schwonberg, Kirsten Orinska, Zane Medina, Eva HENDRIX, Sven Metz, Martin Zenclussen, Ana Claudia von Stebut, Esther Biedermann, Tilo |
Issue Date: | 2019 | Publisher: | MOSBY-ELSEVIER | Source: | JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 144(4), p. S4-S18 | Abstract: | Mast cells (MCs), which are well known for their effector functions in T(H)2-skewed allergic and also autoimmune inflammation, have become increasingly acknowledged for their role in protection of health. It is now clear that they are also key modulators of immune responses at interface organs, such as the skin or gut. MCs can prime tissues for adequate inflammatory responses and cooperate with dendritic cells in T-cell activation. They also regulate harmful immune responses in trauma and help to successfully orchestrate pregnancy. This review focuses on the beneficial effects of MCs on tissue homeostasis and elimination of toxins or venoms. MCs can enhance pathogen clearance in many bacterial, viral, and parasitic infections, such as through Toll-like receptor 2-triggered degranulation, secretion of antimicrobial cathelicidins, neutrophil recruitment, or provision of extracellular DNA traps. The role of MCs in tumors is more ambiguous; however, encouraging new findings show they can change the tumor microenvironment toward antitumor immunity when adequately triggered. Uterine tissue remodeling by alpha-chymase (mast cell protease [MCP] 5) is crucial for successful embryo implantation. MCP-4 and the tryptase MCP-6 emerge to be protective in central nervous system trauma by reducing inflammatory damage and excessive scar formation, thereby protecting axon growth. Last but not least, proteases, such as carboxypeptidase A, released by Fc epsilon RI-activated MCs detoxify an increasing number of venoms and endogenous toxins. A better understanding of the plasticity of MCs will help improve these advantageous effects and hint at ways to cut down detrimental MC actions. | Notes: | [Dudeck, Anne; Dudeck, Jan] Otto von Guericke Univ, Med Fac, Inst Mol & Clin Immunol, Hlth Campus Immunol Infectiol & Inflammat, Magdeburg, Germany. [Koeberle, Martin; Biedermann, Tilo] Tech Univ Munich, Dept Dermatol & Allergol, Biedersteinerstr 29, D-80802 Munich, Germany. [Goldmann, Oliver; Medina, Eva] Helmholtz Ctr Infect Res, Infect Immunol Res Grp, Braunschweig, Germany. [Rohde, Manfred] Helmholtz Ctr Infect Res, Cent Facil Microscopy, Braunschweig, Germany. [Meyer, Nicole; Zenclussen, Ana Claudia] Otto von Guericke Univ, Med Fac, Expt Obstet & Gynecol, Magdeburg, Germany. [Lemmens, Stefanie; Hendrix, Sven] Hasselt Univ, Biomed Res Inst, Dept Morphol, Diepenbeek, Belgium. [Roldan, Nestor Gonzalez] German Ctr Lung Res DZL, Jr Grp Allergobiochem, Res Ctr Borstel, Leibniz Lung Ctr,ARCN, Munich, Germany. [Orinska, Zane] German Ctr Lung Res DZL, Div Expt Pneumol, Res Ctr Borstel, Leibniz Lung Ctr,ARCN, Munich, Germany. [Dietze-Schwonberg, Kirsten; von Stebut, Esther] Johannes Gutenberg Univ Mainz, Univ Med Ctr, Dept Dermatol, Mainz, Germany. [Metz, Martin] Charite, Klin Dermatol Venerol & Allergol, Berlin, Germany. [von Stebut, Esther] Univ Cologne, Dept Dermatol, Cologne, Germany. [Biedermann, Tilo] German Res Ctr Environm Hlth GmbH, Helmholtz Zentrum Munchen, EKA, Neuherberg, Germany. | Keywords: | Mast cell; innate immunity; infection; mast cell protease; tumor; pregnancy; venom; toxin; central nervous system trauma;Mast cell; innate immunity; infection; mast cell protease; tumor; pregnancy; venom; toxin; central nervous system trauma | Document URI: | http://hdl.handle.net/1942/29908 | ISSN: | 0091-6749 | e-ISSN: | 1097-6825 | DOI: | 10.1016/j.jaci.2018.10.054 | ISI #: | 000488805000002 | Rights: | 2018 The Authors. Published by Elsevier Inc. on behalf of the American Academy ofAllergy, Asthma & Immunology. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2020 |
Appears in Collections: | Research publications |
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