Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/29913
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | CHERUKU, Srujan | - |
dc.contributor.author | D'OLIESLAEGER, Lien | - |
dc.contributor.author | SMISDOM, Nick | - |
dc.contributor.author | Smits, Joeri | - |
dc.contributor.author | VANDERZANDE, Dirk | - |
dc.contributor.author | MAES, Wouter | - |
dc.contributor.author | AMELOOT, Marcel | - |
dc.contributor.author | ETHIRAJAN, Anitha | - |
dc.date.accessioned | 2019-11-04T15:15:58Z | - |
dc.date.available | 2019-11-04T15:15:58Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | Materials, 12(15) (Art N° 2497) | - |
dc.identifier.issn | 1996-1944 | - |
dc.identifier.uri | http://hdl.handle.net/1942/29913 | - |
dc.description.abstract | Conjugated polymer nanoparticles exhibit very interesting properties for use as bio-imaging agents. In this paper, we report the synthesis of PCDTBT (poly([9-(1’-octylnonyl)- 9H-carbazole-2,7-diyl]-2,5-thiophenediyl-2,1,3-benzothiadiazole-4,7-diyl-2,5-thiophene-diyl)) nanoparticles of varying sizes using the mini-emulsion and emulsion/solvent evaporation approach. The effect of the size of the particles on the optical properties is investigated using UV-Vis absorption and fluorescence emission spectroscopy. It is shown that PCDTBT nanoparticles have a fluorescence emission maximum around 710 nm, within the biological near-infrared “optical window”. The photoluminescence quantum yield shows a characteristic trend as a function of size. The particles are not cytotoxic and are taken up successfully by human lung cancer carcinoma A549 cells. Irrespective of the size, all particles show excellent fluorescent brightness for bioimaging. The fidelity of the particles as fluorescent probes to study particle dynamics in situ is shown as a proof of concept by performing raster image correlation spectroscopy. Combined, these results show that PCDTBT is an excellent candidate to serve as a fluorescent probe for near-infrared bio-imaging. | - |
dc.description.sponsorship | The authors acknowledge the support by Hasselt University (BOF) and the Research Foundation-Flanders (FWO). Srujan Cheruku is an FWO doctoral fellow. | - |
dc.language.iso | en | - |
dc.rights | 2019 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). | - |
dc.subject.other | conjugated polymer nanoparticles; mini-emulsion; bio-imaging; raster image correlation spectroscopy | - |
dc.title | Fluorescent PCDTBT Nanoparticles with Tunable Size for Versatile Bioimaging | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 15 | - |
dc.identifier.volume | 12 | - |
local.bibliographicCitation.jcat | A1 | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | 2497 | - |
dc.identifier.doi | 10.3390/ma12152497 | - |
dc.identifier.isi | 000482576900158 | - |
item.accessRights | Open Access | - |
item.fullcitation | CHERUKU, Srujan; D'OLIESLAEGER, Lien; SMISDOM, Nick; Smits, Joeri; VANDERZANDE, Dirk; MAES, Wouter; AMELOOT, Marcel & ETHIRAJAN, Anitha (2019) Fluorescent PCDTBT Nanoparticles with Tunable Size for Versatile Bioimaging. In: Materials, 12(15) (Art N° 2497). | - |
item.contributor | CHERUKU, Srujan | - |
item.contributor | D'OLIESLAEGER, Lien | - |
item.contributor | SMISDOM, Nick | - |
item.contributor | Smits, Joeri | - |
item.contributor | VANDERZANDE, Dirk | - |
item.contributor | MAES, Wouter | - |
item.contributor | AMELOOT, Marcel | - |
item.contributor | ETHIRAJAN, Anitha | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2020 | - |
crisitem.journal.eissn | 1996-1944 | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
materials-12-02497.pdf | Published version | 20.88 MB | Adobe PDF | View/Open |
SCOPUSTM
Citations
1
checked on Sep 7, 2020
WEB OF SCIENCETM
Citations
6
checked on Sep 20, 2024
Page view(s)
134
checked on Jun 13, 2022
Download(s)
152
checked on Jun 13, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.