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Title: | Households or Hotspots? Defining Intervention Targets for Malaria Elimination in Ratanakiri Province, Eastern Cambodia | Authors: | Bannister-Tyrrell, Melanie Krit, Meryam Sluydts, Vincent Tho, Sochantha Sokny, Mao Mean, Vanna Kim, Saorin Menard, Didier Grietens, Koen Peeters ABRAMS, Steven HENS, Niel Coosemans, Marc Bassat, Quique van Hensbroek, Michael Boele Durnez, Lies Van Bortel, Wim |
Issue Date: | 2019 | Publisher: | OXFORD UNIV PRESS INC | Source: | JOURNAL OF INFECTIOUS DISEASES, 220(6), p. 1034-1043 | Abstract: | Background. Malaria "hotspots" have been proposed as potential intervention units for targeted malaria elimination. Little is known about hotspot formation and stability in settings outside sub-Saharan Africa. Methods. Clustering of Plasmodium infections at the household and hotspot level was assessed over 2 years in 3 villages in eastern Cambodia. Social and spatial autocorrelation statistics were calculated to assess clustering of malaria risk, and logistic regression was used to assess the effect of living in a malaria hotspot compared to living in a malaria-positive household in the first year of the study on risk of malaria infection in the second year. Results. The crude prevalence of Plasmodium infection was 8.4% in 2016 and 3.6% in 2017. Living in a hotspot in 2016 did not predict Plasmodium risk at the individual or household level in 2017 overall, but living in a Plasmodium-positive household in 2016 strongly predicted living in a Plasmodium-positive household in 2017 (Risk Ratio, 5.00 [95% confidence interval, 2.09-11.96], P < .0001). There was no consistent evidence that malaria risk clustered in groups of socially connected individuals from different households. Conclusions. Malaria risk clustered more clearly in households than in hotspots over 2 years. Household-based strategies should be prioritized in malaria elimination programs in this region. | Notes: | [Bannister-Tyrrell, Melanie; Krit, Meryam; Sluydts, Vincent; Grietens, Koen Peeters; Coosemans, Marc; Durnez, Lies; Van Bortel, Wim] Inst Trop Med, Natl Str 155, B-2000 Antwerp, Belgium. [Sluydts, Vincent; Abrams, Steven; Hens, Niel; Durnez, Lies] Univ Antwerp, Antwerp, Belgium. [Tho, Sochantha; Sokny, Mao] Natl Ctr Parasitol Entomol & Malaria Control, Phnom Penh, Cambodia. [Mean, Vanna] Ratanakiri Prov Hlth Dept, Banlung, Cambodia. [Kim, Saorin; Menard, Didier] Pasteur Inst, Phnom Penh, Cambodia. [Abrams, Steven; Hens, Niel] Univ Hasselt, Hasselt, Belgium. [Bassat, Quique] Univ Barcelona, Hosp Clinic, ISGlobal, Barcelona, Spain. [Bassat, Quique] Ctr Invest Saude Manh, Maputo, Mozambique. [Bassat, Quique] Catalan Inst Res & Adv Studies, Barcelona, Spain. [van Hensbroek, Michael Boele] Acad Med Ctr, Amsterdam, Netherlands. [van Hensbroek, Michael Boele] Amsterdam Inst Global Hlth & Dev, Amsterdam, Netherlands. | Keywords: | malaria; hotspot; malaria elimination; Greater Mekong Subregion; epidemiology.;malaria; hotspot; malaria elimination; Greater Mekong Subregion; epidemiology | Document URI: | http://hdl.handle.net/1942/29962 | ISSN: | 0022-1899 | e-ISSN: | 1537-6613 | DOI: | 10.1093/infdis/jiz211 | ISI #: | 000490985400015 | Rights: | The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence http://creativecommons.org/licenses/ by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2020 |
Appears in Collections: | Research publications |
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bannister 1.pdf | Published version | 10.96 MB | Adobe PDF | View/Open |
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