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http://hdl.handle.net/1942/30029
Title: | Microcrack-associated bone remodeling is rarely observed in biopsies from athletes with medial tibial stress syndrome | Authors: | Winters, Marinus Burr, David B. van der Hoeven, Henk Condon, Keith W. BELLEMANS, Johan Moen, Maarten H. |
Issue Date: | 2019 | Publisher: | SPRINGER JAPAN KK | Source: | JOURNAL OF BONE AND MINERAL METABOLISM, 37(3), p. 496-502 | Abstract: | The pathology of medial tibial stress syndrome (MTSS) is unknown. Studies suggest that MTSS is a bony overload injury, but histological evidence is sparse. The presence of microdamage, and its potential association with targeted remodeling, could provide evidence for the pathogenesis of MTSS. Understanding the pathology underlying MTSS could contribute to effective preventative and therapeutic interventions for MTSS. Our aim was to retrospectively evaluate biopsies, previously taken from the painful area in athletes with MTSS, for the presence of linear microcracks, diffuse microdamage and remodeling. Biopsies, previously taken from athletes with MTSS, were evaluated at the Department of Anatomy and Cell Biology at the Indiana University. After preparing the specimens by en bloc staining, one investigator evaluated the presence of linear microcracks, diffuse microdamage and remodeling in the specimens. A total of six biopsies were evaluated for the presence of microdamage and remodeling. Linear microcracks were found in 4 out of 6 biopsies. Cracking in one of these specimens was artefactual due to the biopsy procedure. No diffuse microdamage was seen in any of the specimens, and only one potential remodeling front in association with the microcracks. We found only linear microcracks in vivo in biopsies taken from the painful area in 50% of the athletes with MTSS, consistent with the relationship between linear cracks and fatigue-associated overloading of bone. The nearly universal absence of a repair reaction was notable. This suggests that unrepaired microdamage accumulation may underlie the pathophysiological basis for MTSS in athletes. | Notes: | [Winters, Marinus] Aalborg Univ, Dept Clin Med, Res Unit Gen Practice Aalborg, DK-9220 Aalborg, Denmark. [Burr, David B.; Condon, Keith W.] Indiana Univ Sch Med, Dept Anat & Cell Biol, Indianapolis, IN 46202 USA. [Burr, David B.] Indiana Univ Purdue Univ, Dept Biomed Engn, Indianapolis, IN 46202 USA. [van der Hoeven, Henk; Moen, Maarten H.] Bergman Clin, Naarden, Netherlands. [Bellemans, Johan] Univ Hasselt, ZOL Hosp Genk, Dept Orthoped, Genk, Belgium. [Moen, Maarten H.] OLVG Hosp Amsterdam, Sportsphys Grp, Amsterdam, Netherlands. | Keywords: | Medial tibial stress syndrome; Shin splints; Pathology; Bone; Microdamage;Medial tibial stress syndrome; Shin splints; Pathology; Bone; Microdamage | Document URI: | http://hdl.handle.net/1942/30029 | ISSN: | 0914-8779 | e-ISSN: | 1435-5604 | DOI: | 10.1007/s00774-018-0945-9 | ISI #: | 000466447800011 | Rights: | The Japanese Society for Bone and Mineral Research and Springer Japan KK, part of Springer Nature 2018 | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2020 |
Appears in Collections: | Research publications |
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