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Title: | Evaluation of rodent control to fight Lassa fever based on field data and mathematical modelling | Authors: | Marien, Joachim BORREMANS, Benny Kourouma, Fode Baforday, Jatta Rieger, Toni Guenther, Stephan Magassouba, N'Faly Leirs, Herwig Fichet-Calvet, Elisabeth |
Issue Date: | 2019 | Publisher: | TAYLOR & FRANCIS LTD | Source: | EMERGING MICROBES & INFECTIONS, 8(1), p. 640-649 | Abstract: | The Natal multimammate mouse (Mastomys natalensis) is the reservoir host of Lassa virus, an arenavirus that causes Lassa haemorrhagic fever in humans in West Africa. Because no vaccine exists and therapeutic options are limited, preventing infection through rodent control and human behavioural measures is currently considered to be the only option. In order to assess the efficacy of rodent control, we performed a 4-year field experiment in rural Upper Guinea and developed a mathematical model to simulate different control strategies (annual density control, continuous density control, and rodent vaccination). For the field study, rodenticide baits were placed each year in three rural villages, while three other villages were used as controls. Rodents were trapped before and after every treatment and their antibody status and age were determined. Data from the field study were used to parameterize the mathematical model. In the field study, we found a significant negative effect of rodent control on seroprevalence, but this effect was small especially given the effort. Furthermore, the rodent populations recovered rapidly after rodenticide application, leading us to conclude that an annual control strategy is unlikely to significantly reduce Lassa virus spillover to humans. In agreement with this finding, the mathematical model suggests that the use of continuous control or rodent vaccination is the only strategy that could lead to Lassa virus elimination. These field and model results can serve as a guide for determining how long and frequent rodent control should be done in order to eliminate Lassa virus in rural villages. | Notes: | [Marien, Joachim; Leirs, Herwig] Univ Antwerp, Evolutionary Ecol Grp, Univ Pl 1, B-2610 Antwerp, Belgium. [Borremans, Benny] Univ Calif Los Angeles, Los Angeles, CA USA. [Borremans, Benny] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat I BIOST, Hasselt, Belgium. [Kourouma, Fode; Magassouba, N'Faly] Lab Fievres Hemorrag, Nongo, Guinea. [Baforday, Jatta; Rieger, Toni; Guenther, Stephan; Fichet-Calvet, Elisabeth] Bernhard Nocht Inst Trop Med, Hamburg, Germany. | Keywords: | Lassa virus;Mastomys natalensis;rodent control;rodent vaccination;arenavirus;rodent-borne virus | Document URI: | http://hdl.handle.net/1942/30061 | e-ISSN: | 2222-1751 | DOI: | 10.1080/22221751.2019.1605846 | ISI #: | 000465140800001 | Rights: | 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group, on behalf of Shanghai Shangyixun Cultural Communication Co., Ltd This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2020 |
Appears in Collections: | Research publications |
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marien 1.pdf | Published version | 1.88 MB | Adobe PDF | View/Open |
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