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http://hdl.handle.net/1942/30086
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DC Field | Value | Language |
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dc.contributor.author | Heyer, F. L. | - |
dc.contributor.author | de Jong, J. J. A. | - |
dc.contributor.author | Willems, P. C. | - |
dc.contributor.author | Arts, J. J. | - |
dc.contributor.author | Bours, S. G. P. | - |
dc.contributor.author | van Kuijk, S. M. J. | - |
dc.contributor.author | Poeze, M. | - |
dc.contributor.author | GEUSENS, Piet | - |
dc.contributor.author | van Rietbergen, B. | - |
dc.contributor.author | VAN DEN BERGH, Joop | - |
dc.date.accessioned | 2019-12-06T08:47:21Z | - |
dc.date.available | 2019-12-06T08:47:21Z | - |
dc.date.issued | 2019 | - |
dc.identifier.citation | BONE, 127, p. 510-516 | - |
dc.identifier.uri | http://hdl.handle.net/1942/30086 | - |
dc.description.abstract | Identifying determinants of long-term functional outcome after a distal radius fracture is challenging. Previously, we reported on the association between early HR-pQCT measurements and clinical outcome 12 weeks after a conservatively treated distal radius fracture. We extended the follow-up and assessed functional outcome after two years in relation to early HR-pQCT derived bone parameters. HR-pQCT scans of the fracture region were performed in 15 postmenopausal women with a distal radius fracture at 1-2 (baseline), 3-4 weeks and 26 months post-fracture. Additionally, the contralateral distal radius was scanned at baseline. Bone density, micro-architecture parameters and bone stiffness using micro-finite element analysis (FEA) were evaluated. During all visits, wrist pain and function were assessed using the patient-rated wrist evaluation questionnaire (PRWE), quantifying functional outcome with a score between 0 and 100. Two-year PRWE was associated with torsional and bending stiffness 3-4 weeks post-fracture (R-2: 0.49, p = 0.006 and R-2: 0.54, p = 0.003, respectively). In contrast, early micro-architecture parameters of the fracture region or contralateral bone parameters did not show any association with long-term outcome. This exploratory study indicates that HR-pQCT with mu FEA performed within four weeks after a distal radius fracture captures biomechanical fracture characteristics that are associated with long-term functional outcome and therefore could be a valuable early outcome measure in clinical trials and clinical practice. | - |
dc.description.sponsorship | The authors would like to thank The Weijerhorst Foundation for their supporting grant and Liesbeth Jutten and Margareth Winants for their support with study logistics. | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER SCIENCE INC | - |
dc.rights | 2019 Elsevier Inc. All rights reserved. | - |
dc.subject.other | Fracture healing | - |
dc.subject.other | Functional outcome | - |
dc.subject.other | HR-pQCT | - |
dc.subject.other | Finite element analysis | - |
dc.title | Long-term functional outcome of distal radius fractures is associated with early post-fracture bone stiffness of the fracture region: An HR-pQCT exploratory study | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 516 | - |
dc.identifier.spage | 510 | - |
dc.identifier.volume | 127 | - |
local.format.pages | 7 | - |
local.bibliographicCitation.jcat | A1 | - |
dc.description.notes | [Heyer, F. L.; Poeze, M.; van den Bergh, J. P.] Maastricht Univ, Res Sch NUTRIM, Maastricht, Netherlands. [Heyer, F. L.; Poeze, M.] Maastricht Univ, Med Ctr, Dept Surg, Maastricht, Netherlands. [Heyer, F. L.; van den Bergh, J. P.] VieCuri Med Ctr Venlo, Dept Internal Med, Venray, Netherlands. [de Jong, J. J. A.] Maastricht Univ, Med Ctr, Dept Radiol, Maastricht, Netherlands. [Willems, P. C.; Arts, J. J.; Geusens, P. P.] Maastricht Univ, Res Sch CAPHRI, Maastricht, Netherlands. [Willems, P. C.; Arts, J. J.] Maastricht Univ, Med Ctr, Dept Orthoped Surg, Maastricht, Netherlands. [Bours, S. G. P.; Geusens, P. P.; van den Bergh, J. P.] Maastricht Univ, Med Ctr, Dept Rheumatol, Maastricht, Netherlands. [van Kuijk, S. M. J.] Maastricht Univ, Med Ctr, Dept Clin Epidemiol & Med Technol Assessment, Maastricht, Netherlands. [Geusens, P. P.; van den Bergh, J. P.] Hasselt Univ, Fac Med & Life Sci, Hasselt, Belgium. [van Rietbergen, B.] Eindhoven Univ Technol, Fac Biomed Engn, Eindhoven, Netherlands. | - |
local.publisher.place | NEW YORK | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.identifier.doi | 10.1016/j.bone.2019.06.013 | - |
dc.identifier.isi | 000483449000059 | - |
item.validation | ecoom 2020 | - |
item.accessRights | Restricted Access | - |
item.fullcitation | Heyer, F. L.; de Jong, J. J. A.; Willems, P. C.; Arts, J. J.; Bours, S. G. P.; van Kuijk, S. M. J.; Poeze, M.; GEUSENS, Piet; van Rietbergen, B. & VAN DEN BERGH, Joop (2019) Long-term functional outcome of distal radius fractures is associated with early post-fracture bone stiffness of the fracture region: An HR-pQCT exploratory study. In: BONE, 127, p. 510-516. | - |
item.fulltext | With Fulltext | - |
item.contributor | Heyer, F. L. | - |
item.contributor | de Jong, J. J. A. | - |
item.contributor | Willems, P. C. | - |
item.contributor | Arts, J. J. | - |
item.contributor | Bours, S. G. P. | - |
item.contributor | van Kuijk, S. M. J. | - |
item.contributor | Poeze, M. | - |
item.contributor | GEUSENS, Piet | - |
item.contributor | van Rietbergen, B. | - |
item.contributor | VAN DEN BERGH, Joop | - |
crisitem.journal.issn | 8756-3282 | - |
crisitem.journal.eissn | 1873-2763 | - |
Appears in Collections: | Research publications |
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heyer 1.pdf Restricted Access | Published version | 1.5 MB | Adobe PDF | View/Open Request a copy |
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