Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/30143
Title: | The association between prevalent vertebral fractures and bone quality of the distal radius and distal tibia as measured with HR-pQCT in postmenopausal women with a recent non-vertebral fracture at the Fracture Liaison Service | Authors: | Vranken, L. Wyers, C. E. van Rietbergen, B. Driessen, J. H. M. GEUSENS, Piet Janzing, H. M. J. van der Velde, R. Y. VAN DEN BERGH, Joop |
Issue Date: | 2019 | Publisher: | SPRINGER LONDON LTD | Source: | OSTEOPOROSIS INTERNATIONAL, 30(9), p. 1789-1797 | Abstract: | We evaluated the association between prevalent vertebral fractures and bone micro-architecture and strength measured using HR-pQCT in postmenopausal women with a recent non-vertebral fracture visiting the Fracture Liaison Service. The presence and severity of prevalent vertebral fracture reflect generalized bone deterioration. Introduction We evaluated the association between prevalent vertebral fractures (VFs) and bone micro-architecture and strength measured using HR-pQCT in postmenopausal women visiting the Fracture Liaison Service. Methods In this cross-sectional study in women aged 50-90 with a recent non-vertebral fracture (NVF), VFs were identified on lateral spine images by dual-energy X-ray absorptiometry. Bone micro-architecture and strength were measured at the non-dominant distal radius and distal tibia using HR-pQCT. Linear regression analyses were used to estimate the association between prevalent VFs and HR-pQCT parameters. Results We included 338 women of whom 74 (21.9%) women had at least one prevalent VF. After adjustment for femoral neck aBMD (FN aBMD) and other parameters, women with at least one prevalent vertebral fracture had significantly lower total and trabecular vBMD and trabecular number (beta - 16.7, - 11.8, and - 7.8 in the radius and - 21.4, - 16.6, and - 7.2 in the tibia, respectively), higher trabecular separation at the radius and tibia (beta 9.0 and 9.3, respectively), and lower cortical thickness and calculated ultimate failure load and compressive bone strength at the tibia (beta - 5.9, - 0.6, and - 10.9, respectively) as compared with those without prevalent VFs. Furthermore, more severe prevalent VFs were associated with even lower total and trabecular vBMD and lower ultimate failure load and compressive stiffness at the radius and tibia, and lower trabecular number and higher trabecular separation at the radius. Conclusion This study indicates that the presence and severity of prevalent VFs reflect generalized bone deterioration in women with a recent NVF, independently of FN aBMD. | Notes: | [Vranken, L.; Wyers, C. E.; van der Velde, R. Y.; van den Bergh, J. P. W.] VieCuri Med Ctr, Dept Internal Med, POB 1926, NL-5900 BX Venlo, Netherlands. [Vranken, L.; Wyers, C. E.; van der Velde, R. Y.; van den Bergh, J. P. W.] Maastricht Univ, Dept Internal Med, Med Ctr, POB 616, NL-6200 MD Maastricht, Netherlands. [Vranken, L.; Wyers, C. E.; Driessen, J. H. M.; van der Velde, R. Y.; van den Bergh, J. P. W.] Maastricht Univ, NUTRIM Sch Nutr & Translat Res Metab, Maastricht, Netherlands. [van Rietbergen, B.] Eindhoven Univ Technol, Fac Biomed Engn, Eindhoven, Netherlands. [van Rietbergen, B.] Maastricht Univ, Dept Orthopaed Surg, Med Ctr, POB 616, NL-6200 MD Maastricht, Netherlands. [Driessen, J. H. M.] Maastricht Univ, Dept Clin Phannacy & Toxicol, Med Ctr, POB 616, NL-6200 MD Maastricht, Netherlands. [Driessen, J. H. M.; Geusens, P. P. M. M.] Maastricht Univ, CAPHRI Sch Publ Hlth & Primary Care, Maastricht, Netherlands. [Geusens, P. P. M. M.] Maastricht Univ, Med Ctr, Subdiv Rheumatol, Dept Internal Med, POB 616, NL-6200 MD Maastricht, Netherlands. [Geusens, P. P. M. M.; van den Bergh, J. P. W.] Hasselt Univ, Biomed Res Ctr, B-3590 Diepenbeek, Belgium. [Janzing, H. M. J.; van den Bergh, J. P. W.] VieCuri Med Ctr, Dept Surg, POB 1926, NL-5900 BX Venlo, Netherlands. | Keywords: | Fracture Liaison Service; HR-pQCT; Vertebral fractures;Endocrinology & Metabolism | Document URI: | http://hdl.handle.net/1942/30143 | ISSN: | 0937-941X | e-ISSN: | 1433-2965 | DOI: | 10.1007/s00198-019-05081-9 | ISI #: | 000483690500008 | Rights: | Open Access This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http:// creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2020 |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
vranken 1.pdf | Published version | 314.52 kB | Adobe PDF | View/Open |
SCOPUSTM
Citations
2
checked on Sep 3, 2020
WEB OF SCIENCETM
Citations
8
checked on Apr 22, 2024
Page view(s)
24
checked on Sep 7, 2022
Download(s)
8
checked on Sep 7, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.