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Title: Oncostatin M, an Underestimated Player in the Central Nervous System
Authors: HOUBEN, Evelien 
BROUX, Bieke 
Issue Date: 2019
Source: FRONTIERS IN IMMUNOLOGY, 10 (Art N° 1165)
Abstract: For a long time, the central nervous system (CNS) was believed to be an immune privileged organ. In the last decades, it became apparent that the immune system interacts with the CNS not only in pathological, but also in homeostatic situations. It is now clear that immune cells infiltrate the healthy CNS as part of immune surveillance and that immune cells communicate through cytokines with CNS resident cells. In pathological conditions, an enhanced infiltration of immune cells takes place to fight the pathogen. A well-known family of cytokines is the interleukin (IL)-6 cytokine family. All members are important in cell communication and cell signaling in the immune system. One of these members is oncostatin M (OSM), for which the receptor is expressed on several cells of the CNS. However, the biological function of OSM in the CNS is not studied in detail. Here, we briefly describe the general aspects related to OSM biology, including signaling and receptor binding. Thereafter, the current understanding of OSM during CNS homeostasis and pathology is summarized.
Notes: [Houben, Evelien; Hellings, Niels; Broux, Bieke] Hasselt Univ, Biomed Res Inst, Dept Immunol, Diepenbeek, Belgium.
Keywords: Oncostatin M (OSM);central nervous system;cell biology;homeostasis;pathology
Document URI:
ISSN: 1664-3224
e-ISSN: 1664-3224
DOI: 10.3389/fimmu.2019.01165
ISI #: 000469432700001
Rights: © 2019 Houben, Hellings and Broux. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
Category: A1
Type: Journal Contribution
Validations: ecoom 2020
Appears in Collections:Research publications

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