Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/30162
Title: Meta-analysis of epigenome-wide association studies in neonates reveals widespread differential DNA methylation associated with birthweight
Authors: Kupers, Leanne K.
Monnereau, Claire
Sharp, Gemma C.
Yousefi, Paul
Salas, Lucas A.
Ghantous, Akram
Page, Christian M.
Reese, Sarah E.
Wilcox, Allen J.
Czamara, Darina
Starling, Anne P.
Novoloaca, Alexei
Lent, Samantha
Roy, Ritu
Hoyo, Cathrine
Breton, Carrie, V
Allard, Catherine
Just, Allan C.
Bakulski, Kelly M.
Holloway, John W.
Everson, Todd M.
Xu, Cheng-Jian
Huang, Rae-Chi
van der Plaat, Diana A.
Wielscher, Matthias
Merid, Simon Kebede
Ullemar, Vilhelmina
Rezwan, Faisal, I
Lahti, Jari
van Dongen, Jenny
LANGIE, Sabine 
Richardson, Tom G.
Magnus, Maria C.
Nohr, Ellen A.
Xu, Zongli
Duijts, Liesbeth
Zhao, Shanshan
Zhang, Weiming
PLUSQUIN, Michelle 
DeMeo, Dawn L.
Solomon, Olivia
Heimovaara, Joosje H.
Jima, Dereje D.
Gao, Lu
Bustamante, Mariona
Perron, Patrice
Wright, Robert O.
Hertz-Picciotto, Irva
Zhang, Hongmei
Karagas, Margaret R.
Gehring, Ulrike
Marsit, Carmen J.
Beilin, Lawrence J.
Vonk, Judith M.
Jarvelin, Marjo-Riitta
Bergstrom, Anna
Ortqvist, Anne K.
Ewart, Susan
Villa, Pia M.
Moore, Sophie E.
Willemsen, Gonneke
Standaert, Arnout R. L.
Haberg, Siri E.
Sorensen, Thorkild I. A.
Taylor, Jack A.
Raikkonen, Katri
Yang, Ivana, V
Kechris, Katerina
NAWROT, Tim 
Silver, Matt J.
Gong, Yun Yun
Richiardi, Lorenzo
Kogevinas, Manolis
Litonjua, Augusto A.
Eskenazi, Brenda
Huen, Karen
Mbarek, Hamdi
Maguire, Rachel L.
Dwyer, Terence
Vrijheid, Martine
Bouchard, Luigi
Baccarelli, Andrea A.
Croen, Lisa A.
Karmaus, Wilfried
Anderson, Denise
de Vries, Maaike
Sebert, Sylvain
Kere, Juha
Karlsson, Robert
Arshad, Syed Hasan
Hamalainen, Esa
Routledge, Michael N.
Boomsma, Dorret, I
Feinberg, Andrew P.
Newschaffer, Craig J.
Govarts, Eva
Moisse, Matthieu
Fallin, M. Daniele
Melen, Erik
Prentice, Andrew M.
Kajantie, Eero
Almqvist, Catarina
Oken, Emily
Dabelea, Dana
Boezen, H. Marike
Melton, Phillip E.
Wright, Rosalind J.
Koppelman, Gerard H.
Trevisi, Letizia
Hivert, Marie-France
Sunyer, Jordi
Munthe-Kaas, Monica C.
Murphy, Susan K.
Corpeleijn, Eva
Wiemels, Joseph
Holland, Nina
Herceg, Zdenko
Binder, Elisabeth B.
Smith, George Davey
Jaddoe, Vincent W. V.
Lie, Rolv T.
Nystad, Wenche
London, Stephanie J.
Lawlor, Debbie A.
Relton, Caroline L.
Snieder, Harold
Felix, Janine F.
Issue Date: 2019
Publisher: NATURE PUBLISHING GROUP
Source: NATURE COMMUNICATIONS, 10 (Art N° 1893)
Abstract: Birthweight is associated with health outcomes across the life course, DNA methylation may be an underlying mechanism. In this meta-analysis of epigenome-wide association studies of 8,825 neonates from 24 birth cohorts in the Pregnancy And Childhood Epigenetics Consortium, we find that DNA methylation in neonatal blood is associated with birthweight at 914 sites, with a difference in birthweight ranging from -183 to 178 grams per 10% increase in methylation (P-Bonferroni < 1.06 x 10(-7)). In additional analyses in 7,278 participants, <1.3% of birthweight-associated differential methylation is also observed in childhood and adolescence, but not adulthood. Birthweight-related CpGs overlap with some Bonferroni-significant CpGs that were previously reported to be related to maternal smoking (55/914, p = 6.12 x 10(-74)) and BMI in pregnancy (3/914, p = 1.13x10(-3)), but not with those related to folate levels in pregnancy. Whether the associations that we observe are causal or explained by confounding or fetal growth influencing DNA methylation (i.e. reverse causality) requires further research.
Notes: [Kupers, Leanne K.; Sharp, Gemma C.; Yousefi, Paul; Richardson, Tom G.; Magnus, Maria C.; Sorensen, Thorkild I. A.; Smith, George Davey; Lawlor, Debbie A.; Relton, Caroline L.] Univ Bristol, MRC Integrat Epidemiol Unit, Bristol, Avon, England. [Kupers, Leanne K.; Yousefi, Paul; Richardson, Tom G.; Magnus, Maria C.; Smith, George Davey; Lawlor, Debbie A.; Relton, Caroline L.] Univ Bristol, Bristol Med Sch, Populat Hlth Sci, Bristol, Avon, England. [Kupers, Leanne K.; van der Plaat, Diana A.; Heimovaara, Joosje H.; Vonk, Judith M.; de Vries, Maaike; Boezen, H. Marike; Corpeleijn, Eva; Snieder, Harold] Univ Groningen, Univ Med Ctr Groningen, Dept Epidemiol, Groningen, Netherlands. [Kupers, Leanne K.; Duijts, Liesbeth] Wageningen Univ, Div Human Nutr & Hlth, Wageningen, Netherlands. [Monnereau, Claire; Jaddoe, Vincent W. V.; Felix, Janine F.] Univ Med Ctr Rotterdam, Erasmus MC, Generat R Study Grp, Rotterdam, Netherlands. [Monnereau, Claire; Jaddoe, Vincent W. V.; Felix, Janine F.] Univ Med Ctr Rotterdam, Dept Epidemiol, Erasmus MC, Rotterdam, Netherlands. [Monnereau, Claire; Jaddoe, Vincent W. V.; Felix, Janine F.] Univ Med Ctr Rotterdam, Dept Pediat, Erasmus MC, Rotterdam, Netherlands. [Sharp, Gemma C.; Solomon, Olivia] Univ Bristol, Sch Oral & Dent Sci, Bristol, Avon, England. [Yousefi, Paul; Eskenazi, Brenda; Huen, Karen; Holland, Nina] Univ Calif Berkeley, Sch Publ Hlth, Div Environm Hlth Sci, Childrens Environm Hlth Lab, Berkeley, CA 94720 USA. [Salas, Lucas A.; Karagas, Margaret R.] Dartmouth Coll, Geisel Sch Med, Dept Epidemiol, Hanover, NH 03755 USA. [Salas, Lucas A.; Bustamante, Mariona; Kogevinas, Manolis; Vrijheid, Martine; Sunyer, Jordi] Bacelona Inst Global Hlth, ISGlobal, Barcelona, Spain. [Ghantous, Akram; Novoloaca, Alexei; Herceg, Zdenko] Int Agcy Res Canc, Epigenet Grp, Lyon, France. [Page, Christian M.; Magnus, Maria C.; Haberg, Siri E.; Lie, Rolv T.] Norwegian Inst Publ Hlth, Ctr Fertil & Hlth, Oslo, Norway. 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Document URI: http://hdl.handle.net/1942/30162
e-ISSN: 2041-1723
DOI: 10.1038/s41467-019-09671-3
ISI #: 000465201900010
Category: A1
Type: Journal Contribution
Validations: ecoom 2020
Appears in Collections:Research publications

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