Please use this identifier to cite or link to this item: http://hdl.handle.net/1942/30173
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dc.contributor.authorVONCK, Sharona-
dc.contributor.authorStaelens, Anneleen S.-
dc.contributor.authorLANSSENS, Dorien-
dc.contributor.authorTOMSIN, Kathleen-
dc.contributor.authorOBEN, Jolien-
dc.contributor.authorBRUCKERS, Liesbeth-
dc.contributor.authorGYSELAERS, Wilfried-
dc.date.accessioned2019-12-17T13:39:30Z-
dc.date.available2019-12-17T13:39:30Z-
dc.date.issued2019-
dc.identifier.citationJOURNAL OF BIOMEDICAL SCIENCE, 26 (Art N° 38)-
dc.identifier.urihttp://hdl.handle.net/1942/30173-
dc.description.abstractBackgroundTo investigate the possibility of using maternal biophysical parameters only in screening for the different types of gestational hypertensive diseases.MethodsA total of 969 pregnant women were randomly screened in first and second trimester, of which 8 developed Early-onset Preeclampsia, 29 Late-onset Preeclampsia, 35 Gestational Hypertension and 897 women had a normal outcome. An observational maternal hemodynamics assessment was done via standardized electrocardiogram-Doppler ultrasonography, Impedance Cardiography and bio-impedance, acquiring functional information on heart, arteries, veins and body fluid. Preliminary prediction models were developed to test the screening potential for early preeclampsia, late preeclampsia and gestational hypertension using a Partial Least Square Discriminant Analysis.ResultsA combined model using maternal characteristics with cardiovascular parameters in first and second trimester offers high screening performance with Area Under the Curve of 99,9% for Early-onset Preeclampsia, 95,3% for Late-onset Preeclampsia and 94% for Gestational Hypertension.ConclusionsUsing biophysical parameters as fundament for a new prediction model, without the need of biochemical parameters, seems feasible. However, validation in a large prospective study will reveal its true potential.-
dc.description.sponsorshipThe first author of this work is funded by a Ph.D. grant of the Agency for Innovation by Science and Technology (IWT) in Brussels, Belgium. All authors are part of the Limburg Clinical Research Project (LCRP) at Hasselt University, Belgium.-
dc.language.isoen-
dc.publisherBMC-
dc.rightsThe Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.-
dc.subject.otherGestational hypertensive diseases-
dc.subject.otherHypertension-
dc.subject.otherPreeclampsia-
dc.subject.otherScreening-
dc.subject.otherBiophysical parameters-
dc.subject.otherPrediction-
dc.titleDevelopment of a biophysical screening model for gestational hypertensive diseases-
dc.typeJournal Contribution-
dc.identifier.volume26-
local.format.pages9-
local.bibliographicCitation.jcatA1-
dc.description.notes[Vonck, Sharona; Lanssens, Dorien; Gyselaers, Wilfried] Hasselt Univ, Fac Med & Life Sci, Agoralaan, B-3590 Diepenbeek, Belgium. [Vonck, Sharona; Staelens, Anneleen S.; Lanssens, Dorien; Tomsin, Kathleen; Oben, Jolien] Ziekenhuis Oost Limburg, Dept Obstet & Gynaecol, Schiepse Bos 6, B-3600 Genk, Belgium. [Gyselaers, Wilfried] Hasselt Univ, Dept Physiol, Agoralaan, B-3590 Diepenbeek, Belgium. [Bruckers, Liesbeth] Hasselt Univ, Interuniv Inst Biostat & Stat Bioinformat, Agoralaan, B-3590 Diepenbeek, Belgium.-
local.publisher.placeLONDON-
local.type.refereedRefereed-
local.type.specifiedArticle-
local.bibliographicCitation.artnr38-
dc.identifier.doi10.1186/s12929-019-0530-0-
dc.identifier.isi000468535700001-
item.fullcitationVONCK, Sharona; Staelens, Anneleen S.; LANSSENS, Dorien; TOMSIN, Kathleen; OBEN, Jolien; BRUCKERS, Liesbeth & GYSELAERS, Wilfried (2019) Development of a biophysical screening model for gestational hypertensive diseases. In: JOURNAL OF BIOMEDICAL SCIENCE, 26 (Art N° 38).-
item.fulltextWith Fulltext-
item.accessRightsOpen Access-
item.validationecoom 2020-
item.contributorGYSELAERS, Wilfried-
item.contributorBRUCKERS, Liesbeth-
item.contributorStaelens, Anneleen S.-
item.contributorOBEN, Jolien-
item.contributorLANSSENS, Dorien-
item.contributorTOMSIN, Kathleen-
item.contributorVONCK, Sharona-
crisitem.journal.issn1021-7770-
crisitem.journal.eissn1423-0127-
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