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http://hdl.handle.net/1942/30210
Title: | Limits of current male fertility testing | Authors: | Oehninger, Sergio OMBELET, Willem |
Issue Date: | 2019 | Publisher: | ELSEVIER SCIENCE INC | Source: | FERTILITY AND STERILITY, 111(5), p. 835-841 | Abstract: | In the current approach to male fertility testing, basic semen analysis has limitations as a predictor of fertility status, and the technology is fraught with variability. Nonetheless, it remains the cornerstone of the evaluation of the male infertility, and we recommend adherence to most recent World Health Organization guidelines. Although the current sperm function tests (bioassays) have important drawbacks, they are still valuable as research tools. Sperm quality assays with analysis of sperm DNA fragmentation need further investigation before they can be recommended for routine clinical use. The answer to the many current challenging questions relies on identifying spermatogenesis pathologies and the resulting sperm dysfunctions at the cellular and molecular levels. New discoveries may bring answers or new avenues to explore. ((C) 2019 by American Society for Reproductive Medicine.) | Notes: | [Oehninger, Sergio] Sher Fertil Inst, New York, NY USA. [Ombelet, Willem] ZOL Hosp, Genk Inst Fertil Technol, Genk, Belgium. [Ombelet, Willem] Hasselt Univ, Hasselt, Belgium. | Keywords: | DNA fragmentation;fertility;semen analysis;sperm;sperm function tests | Document URI: | http://hdl.handle.net/1942/30210 | ISSN: | 0015-0282 | e-ISSN: | 1556-5653 | DOI: | 10.1016/j.fertnstert.2019.03.005 | ISI #: | 000465563900003 | Rights: | 2019 American Society for Reproductive Medicine, Published by Elsevier Inc. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2020 |
Appears in Collections: | Research publications |
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