Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/30270
Title: | Reduction of amyloid load and cerebral damage in a transgenic mouse model of Alzheimer's disease by treatment with a beta-sheet breaker peptide | Authors: | Permanne, Bruno Adessi, Céline Saborio, Gabriela P Fraga, Santiago Frossard, Marie-José Van Dorpe, Jo DEWACHTER, Ilse Banks, William A Van Leuven, Fred Soto, Claudio |
Issue Date: | 2002 | Publisher: | FEDERATION AMER SOC EXP BIOL | Source: | FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 16 (6) | Abstract: | Genetic, neuropathological, and biochemical studies have provided strong evidence for a central role of amyloid in the pathogenesis of Alzheimer's disease (AD). We have proposed previously that peptides designed as beta-sheet breakers may be useful in preventing the formation of amyloid plaques. In this study, we describe a modified beta-sheet breaker peptide with improved pharmacological properties, a high rate of penetration across the blood-brain barrier, and the ability to induce a dramatic reduction in amyloid deposition in two different transgenic AD models. In addition, we report for the first time a significant increase in neuronal survival and a decrease in brain inflammation associated with the reduction of amyloid plaques. These results demonstrate that the process of amyloid deposition is one of the causes of neurodegeneration in AD. Moreover, our findings indicate that beta-sheet breaker peptides provide a valuable tool for evaluating further the importance of amyloid in the etiology of AD and suggest that these peptides or some of their derivatives might be good candidates for AD treatment. | Keywords: | therapy;protein conformational disorders;neuronal loss;brain inflammation;senile plaques | Document URI: | http://hdl.handle.net/1942/30270 | DOI: | 10.1096/fj.01-0841fje | ISI #: | 000175425900019 | Rights: | 2020 by the Federation of American Societies for Experimental Biology | Category: | A1 | Type: | Journal Contribution |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
fj.01-0841fje.pdf Restricted Access | Published version | 849.95 kB | Adobe PDF | View/Open Request a copy |
SCOPUSTM
Citations
188
checked on Sep 5, 2020
WEB OF SCIENCETM
Citations
192
checked on Oct 5, 2024
Page view(s)
24
checked on Sep 7, 2022
Download(s)
4
checked on Sep 7, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.