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http://hdl.handle.net/1942/30275
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DC Field | Value | Language |
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dc.contributor.author | Sastre, Magdalena | - |
dc.contributor.author | DEWACHTER, Ilse | - |
dc.contributor.author | Landreth, Gary E | - |
dc.contributor.author | Willson, Timothy M | - |
dc.contributor.author | Klockgether, Thomas | - |
dc.contributor.author | van Leuven, Fred | - |
dc.contributor.author | Heneka, Michael T | - |
dc.date.accessioned | 2020-01-10T08:37:47Z | - |
dc.date.available | 2020-01-10T08:37:47Z | - |
dc.date.issued | 2003 | - |
dc.date.submitted | 2020-01-09T12:11:57Z | - |
dc.identifier.citation | The Journal of neuroscience : the official journal of the Society for Neuroscience, 23 (30) , p. 9796-804 -9804 | - |
dc.identifier.uri | http://hdl.handle.net/1942/30275 | - |
dc.description.abstract | Long-term treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) reduces the risk for Alzheimer's disease (AD). To determine the mechanisms by which inflammation affects AD and how NSAIDs protect against it, we stimulated neuroblastoma cells stably transfected with amyloid precursor protein (APP) with proinflammatory cytokines, which increased the secretion of amyloid-beta and APP ectodomain. Addition of ibuprofen, indomethacin, peroxisome proliferator-activated receptor-gamma (PPARgamma) agonists, or cotransfection with PPARgamma cDNA reversed this effect. The inhibitory action of ibuprofen and indomethacin was suppressed by PPARgamma antagonists. Finally, we observed that the mRNA levels, expression, and enzymatic activity of beta-secretase were increased by immunostimulation and normalized by NSAIDs. In conclusion, proinflammatory cytokines activate beta-secretase, and NSAIDs inhibit this effect through PPARgamma. | - |
dc.language.iso | en | - |
dc.publisher | SOC NEUROSCIENCE | - |
dc.rights | © 2003 Society for Neuroscience | - |
dc.subject.other | Cytokine | - |
dc.subject.other | Amyloid Precursor Protein (App) | - |
dc.subject.other | Amyloid- | - |
dc.subject.other | Nsaids | - |
dc.subject.other | Ibuprofen | - |
dc.subject.other | Ppar- | - |
dc.subject.other | Bace1 | - |
dc.title | Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 9804 | - |
dc.identifier.issue | 30 | - |
dc.identifier.spage | 9796-804 | - |
dc.identifier.volume | 23 | - |
local.bibliographicCitation.jcat | A1 | - |
local.publisher.place | 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.source.type | Article | - |
dc.identifier.pmid | 14586007 | - |
dc.identifier.isi | 000186242100012 | - |
dc.identifier.eissn | 1529-2401 | - |
local.provider.type | PubMed | - |
local.uhasselt.uhpub | no | - |
item.fullcitation | Sastre, Magdalena; DEWACHTER, Ilse; Landreth, Gary E; Willson, Timothy M; Klockgether, Thomas; van Leuven, Fred & Heneka, Michael T (2003) Nonsteroidal anti-inflammatory drugs and peroxisome proliferator-activated receptor-gamma agonists modulate immunostimulated processing of amyloid precursor protein through regulation of beta-secretase. In: The Journal of neuroscience : the official journal of the Society for Neuroscience, 23 (30) , p. 9796-804 -9804. | - |
item.fulltext | With Fulltext | - |
item.accessRights | Restricted Access | - |
item.contributor | Sastre, Magdalena | - |
item.contributor | DEWACHTER, Ilse | - |
item.contributor | Landreth, Gary E | - |
item.contributor | Willson, Timothy M | - |
item.contributor | Klockgether, Thomas | - |
item.contributor | van Leuven, Fred | - |
item.contributor | Heneka, Michael T | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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9796.full.pdf Restricted Access | Published version | 491.72 kB | Adobe PDF | View/Open Request a copy |
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