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http://hdl.handle.net/1942/30282
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DC Field | Value | Language |
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dc.contributor.author | Tamboli, I. Y. | - |
dc.contributor.author | Prager, K. | - |
dc.contributor.author | Thal, D. R. | - |
dc.contributor.author | Thelen, K. M. | - |
dc.contributor.author | DEWACHTER, Ilse | - |
dc.contributor.author | Pietrzik, C. U. | - |
dc.contributor.author | St. George-Hyslop, P. | - |
dc.contributor.author | Sisodia, S. S. | - |
dc.contributor.author | De Strooper, B. | - |
dc.contributor.author | Heneka, M. T. | - |
dc.contributor.author | Filippov, M. A. | - |
dc.contributor.author | van Leuven, F. | - |
dc.contributor.author | Muller, U. | - |
dc.contributor.author | Lutjohann, D. | - |
dc.contributor.author | Walter, J. | - |
dc.date.accessioned | 2020-01-10T10:37:27Z | - |
dc.date.available | 2020-01-10T10:37:27Z | - |
dc.date.issued | 2008 | - |
dc.date.submitted | 2020-01-09T11:47:47Z | - |
dc.identifier.citation | Journal of Neuroscience, 28 (46) , p. 12097 -12106 | - |
dc.identifier.uri | http://hdl.handle.net/1942/30282 | - |
dc.description.abstract | Presenilins (PSs) are components of the gamma-secretase complex that mediates intramembranous cleavage of type I membrane proteins. We show that gamma-secretase is involved in the regulation of cellular lipoprotein uptake. Loss of gamma-secretase function decreased endocytosis of low-density lipoprotein (LDL) receptor. The decreased uptake of lipoproteins led to upregulation of cellular cholesterol biosynthesis by increased expression of CYP51 and enhanced metabolism of lanosterol. Genetic deletion of PS1 or transgenic expression of PS1 mutants that cause early-onset Alzheimer's disease led to accumulation of gamma-secretase substrates and mistargeting of adaptor proteins that regulate endocytosis of the LDL receptor. Consistent with decreased endocytosis of these receptors, PS1 mutant mice have elevated levels of apolipoprotein E in the brain. Thus, these data demonstrate a functional link between two major genetic factors that cause early-onset and late-onset Alzheimer's disease. | - |
dc.description.sponsorship | German Research Foundation (DFG) : SFB 645, FOR177 Federal Ministry of Education & Research (BMBF): 01GI0708 University of Bonn | - |
dc.language.iso | English | - |
dc.publisher | SOC NEUROSCIENCE | - |
dc.rights | 2020 by the Society for Neuroscience. | - |
dc.subject.other | presenilin | - |
dc.subject.other | lipoprotein uptake | - |
dc.subject.other | apo E | - |
dc.subject.other | SREBP2 | - |
dc.subject.other | cholesterol | - |
dc.subject.other | APP | - |
dc.title | Loss of -Secretase Function Impairs Endocytosis of Lipoprotein Particles and Membrane Cholesterol Homeostasis | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 12106 | - |
dc.identifier.issue | 46 | - |
dc.identifier.spage | 12097 | - |
dc.identifier.volume | 28 | - |
local.bibliographicCitation.jcat | A1 | - |
local.publisher.place | 11 DUPONT CIRCLE, NW, STE 500, WASHINGTON, DC 20036 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.source.type | Article | - |
dc.identifier.doi | 10.1523/jneurosci.2635-08.2008 | - |
dc.identifier.pmid | 19005074 | - |
dc.identifier.isi | 000260827600041 | - |
dc.identifier.eissn | 1529-2401 | - |
local.provider.type | CrossRef | - |
local.uhasselt.uhpub | no | - |
item.fullcitation | Tamboli, I. Y.; Prager, K.; Thal, D. R.; Thelen, K. M.; DEWACHTER, Ilse; Pietrzik, C. U.; St. George-Hyslop, P.; Sisodia, S. S.; De Strooper, B.; Heneka, M. T.; Filippov, M. A.; van Leuven, F.; Muller, U.; Lutjohann, D. & Walter, J. (2008) Loss of -Secretase Function Impairs Endocytosis of Lipoprotein Particles and Membrane Cholesterol Homeostasis. In: Journal of Neuroscience, 28 (46) , p. 12097 -12106. | - |
item.fulltext | With Fulltext | - |
item.accessRights | Restricted Access | - |
item.contributor | Tamboli, I. Y. | - |
item.contributor | Prager, K. | - |
item.contributor | Thal, D. R. | - |
item.contributor | Thelen, K. M. | - |
item.contributor | DEWACHTER, Ilse | - |
item.contributor | Pietrzik, C. U. | - |
item.contributor | St. George-Hyslop, P. | - |
item.contributor | Sisodia, S. S. | - |
item.contributor | De Strooper, B. | - |
item.contributor | Heneka, M. T. | - |
item.contributor | Filippov, M. A. | - |
item.contributor | van Leuven, F. | - |
item.contributor | Muller, U. | - |
item.contributor | Lutjohann, D. | - |
item.contributor | Walter, J. | - |
crisitem.journal.issn | 0270-6474 | - |
crisitem.journal.eissn | 1529-2401 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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12097.full.pdf Restricted Access | Published version | 590.74 kB | Adobe PDF | View/Open Request a copy |
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