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http://hdl.handle.net/1942/30283
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DC Field | Value | Language |
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dc.contributor.author | Hirata-Fukae, Chiho | - |
dc.contributor.author | Sidahmed, Elkhansa Hassan | - |
dc.contributor.author | Gooskens, Thomas P | - |
dc.contributor.author | Aisen, Paul S | - |
dc.contributor.author | DEWACHTER, Ilse | - |
dc.contributor.author | Devijver, Herman | - |
dc.contributor.author | Van Leuven, Fred | - |
dc.contributor.author | Matsuoka, Yasuji | - |
dc.date.accessioned | 2020-01-10T10:57:50Z | - |
dc.date.available | 2020-01-10T10:57:50Z | - |
dc.date.issued | 2008 | - |
dc.date.submitted | 2020-01-09T11:48:48Z | - |
dc.identifier.citation | Neuroscience letters, 435 (3) , p. 186 -189 | - |
dc.identifier.uri | http://hdl.handle.net/1942/30283 | - |
dc.description.abstract | Beta-site amyloid precursor protein-cleaving enzyme-1 (BACE1) initiates generation of amyloid beta (Abeta), a pathological hallmark of Alzheimer's disease. We investigated the impact of BACE1 protein level on endogenous Abeta. Endogenous Abeta and BACE1 protein levels were concurrently and significantly reduced during early life. However, Abeta levels were similar between BACE1 transgenic and wildtype mice. This suggests that BACE1 protein level has a minimal effect on the level of endogenous Abeta. Consequently, other factors must be involved in modulation of Abeta production in adult and ageing brain and investigation of such factors may yield therapeutic targets. Further, these results suggest that substantial inhibition of BACE1 in brain may be required for clinical benefit in Alzheimer's disease. | - |
dc.description.sponsorship | Antibodies for Abeta ELISA were generously provided byDrs. Yuko Horikoshi-Sakuraba and Noriaki Kinoshita (Immuno-Biological Laboratories, Takasaki, Gunma, Japan). This studywas supported by National Institute of Health (grants AG022455and AG026478 to YM). IDW, HDV and FVL were supportedby the Fonds voor Wetenschappelijk Onderzoek-Vlaanderen(FWO-Vlaanderen). TPG is a visiting student from the Aca-demic Medical Center of the University of Amsterdam, theNetherlands | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER IRELAND LTD | - |
dc.rights | Open Access 2008 Elsevier Ireland Ltd. All rights reserved | - |
dc.subject.other | Alzheimer’s disease | - |
dc.subject.other | Amyloid beta | - |
dc.subject.other | Beta-site amyloid precursor protein (APP)-cleaving enzyme-1 (BACE1) | - |
dc.subject.other | Non-transgenic (wild-type) mice | - |
dc.title | Beta-site amyloid precursor protein-cleaving enzyme-1 (BACE1)-mediated changes of endogenous amyloid beta in wild-type and transgenic mice in vivo | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 189 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 186 | - |
dc.identifier.volume | 435 | - |
local.bibliographicCitation.jcat | A1 | - |
local.publisher.place | ELSEVIER HOUSE, BROOKVALE PLAZA, EAST PARK SHANNON, CO, CLARE, 00000, IRELAND | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.source.type | Article | - |
dc.identifier.doi | 10.1016/j.neulet.2008.02.032 | - |
dc.identifier.pmid | 18343582 | - |
dc.identifier.isi | 000255527300003 | - |
dc.identifier.eissn | 1872-7972 | - |
local.provider.type | PubMed | - |
local.uhasselt.uhpub | no | - |
item.fullcitation | Hirata-Fukae, Chiho; Sidahmed, Elkhansa Hassan; Gooskens, Thomas P; Aisen, Paul S; DEWACHTER, Ilse; Devijver, Herman; Van Leuven, Fred & Matsuoka, Yasuji (2008) Beta-site amyloid precursor protein-cleaving enzyme-1 (BACE1)-mediated changes of endogenous amyloid beta in wild-type and transgenic mice in vivo. In: Neuroscience letters, 435 (3) , p. 186 -189. | - |
item.fulltext | With Fulltext | - |
item.accessRights | Open Access | - |
item.contributor | Hirata-Fukae, Chiho | - |
item.contributor | Sidahmed, Elkhansa Hassan | - |
item.contributor | Gooskens, Thomas P | - |
item.contributor | Aisen, Paul S | - |
item.contributor | DEWACHTER, Ilse | - |
item.contributor | Devijver, Herman | - |
item.contributor | Van Leuven, Fred | - |
item.contributor | Matsuoka, Yasuji | - |
crisitem.journal.issn | 0304-3940 | - |
crisitem.journal.eissn | 1872-7972 | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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1-s2.0-S030439400800222X-main.pdf | Published version | 316.52 kB | Adobe PDF | View/Open |
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