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http://hdl.handle.net/1942/30286
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DC Field | Value | Language |
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dc.contributor.author | Gevaert, Thomas | - |
dc.contributor.author | Vriens, Joris | - |
dc.contributor.author | Segal, Andrei | - |
dc.contributor.author | Everaerts, Wouter | - |
dc.contributor.author | Roskams, Tania | - |
dc.contributor.author | Talavera, Karel | - |
dc.contributor.author | Owsianik, Grzegorz | - |
dc.contributor.author | Liedtke, Wolfgang | - |
dc.contributor.author | Daelemans, Dirk | - |
dc.contributor.author | DEWACHTER, Ilse | - |
dc.contributor.author | Van Leuven, Fred | - |
dc.contributor.author | Voets, Thomas | - |
dc.contributor.author | De Ridder, Dirk | - |
dc.contributor.author | Nilius, Bernd | - |
dc.date.accessioned | 2020-01-10T12:17:17Z | - |
dc.date.available | 2020-01-10T12:17:17Z | - |
dc.date.issued | 2007 | - |
dc.date.submitted | 2020-01-09T11:56:22Z | - |
dc.identifier.citation | The Journal of clinical investigation, 117 (11) , p. 3453-62 -3462 | - |
dc.identifier.uri | http://hdl.handle.net/1942/30286 | - |
dc.description.abstract | Here we provide evidence for a critical role of the transient receptor potential cation channel, subfamily V, member 4 (TRPV4) in normal bladder function. Immunofluorescence demonstrated TRPV4 expression in mouse and rat urothelium and vascular endothelium, but not in other cell types of the bladder. Intracellular Ca2+ measurements on urothelial cells isolated from mice revealed a TRPV4-dependent response to the selective TRPV4 agonist 4alpha-phorbol 12,13-didecanoate and to hypotonic cell swelling. Behavioral studies demonstrated that TRPV4-/- mice manifest an incontinent phenotype but show normal exploratory activity and anxiety-related behavior. Cystometric experiments revealed that TRPV4-/- mice exhibit a lower frequency of voiding contractions as well as a higher frequency of nonvoiding contractions. Additionally, the amplitude of the spontaneous contractions in explanted bladder strips from TRPV4-/- mice was significantly reduced. Finally, a decreased intravesical stretch-evoked ATP release was found in isolated whole bladders from TRPV4-/- mice. These data demonstrate a previously unrecognized role for TRPV4 in voiding behavior, raising the possibility that TRPV4 plays a critical role in urothelium-mediated transduction of intravesical mechanical pressure. | - |
dc.language.iso | en | - |
dc.publisher | AMER SOC CLINICAL INVESTIGATION INC | - |
dc.rights | Open Access. 2020 American Society for Clinical Investigation | - |
dc.subject.other | Heat-Evoked Activation | - |
dc.subject.other | Urinary-Bladder | - |
dc.subject.other | Mice Lacking | - |
dc.subject.other | Vanilloid Receptor | - |
dc.subject.other | P2x Receptors | - |
dc.subject.other | Expression | - |
dc.subject.other | Temperature | - |
dc.subject.other | Rat | - |
dc.subject.other | Urothelium | - |
dc.subject.other | Sensation | - |
dc.title | Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding. | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 3462 | - |
dc.identifier.issue | 11 | - |
dc.identifier.spage | 3453-62 | - |
dc.identifier.volume | 117 | - |
local.bibliographicCitation.jcat | A1 | - |
local.publisher.place | 2015 MANCHESTER RD, ANN ARBOR, MI 48104 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.source.type | Article | - |
dc.identifier.doi | 10.1172/JCI31766 | - |
dc.identifier.pmid | 17948126 | - |
dc.identifier.isi | 000250676000038 | - |
dc.identifier.eissn | 1558-8238 | - |
local.provider.type | PubMed | - |
local.uhasselt.uhpub | no | - |
item.fullcitation | Gevaert, Thomas; Vriens, Joris; Segal, Andrei; Everaerts, Wouter; Roskams, Tania; Talavera, Karel; Owsianik, Grzegorz; Liedtke, Wolfgang; Daelemans, Dirk; DEWACHTER, Ilse; Van Leuven, Fred; Voets, Thomas; De Ridder, Dirk & Nilius, Bernd (2007) Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding.. In: The Journal of clinical investigation, 117 (11) , p. 3453-62 -3462. | - |
item.fulltext | With Fulltext | - |
item.accessRights | Open Access | - |
item.contributor | Gevaert, Thomas | - |
item.contributor | Vriens, Joris | - |
item.contributor | Segal, Andrei | - |
item.contributor | Everaerts, Wouter | - |
item.contributor | Roskams, Tania | - |
item.contributor | Talavera, Karel | - |
item.contributor | Owsianik, Grzegorz | - |
item.contributor | Liedtke, Wolfgang | - |
item.contributor | Daelemans, Dirk | - |
item.contributor | DEWACHTER, Ilse | - |
item.contributor | Van Leuven, Fred | - |
item.contributor | Voets, Thomas | - |
item.contributor | De Ridder, Dirk | - |
item.contributor | Nilius, Bernd | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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31766.2-20150304094807-covered-253bed37ca4c1ab43d105aefdf7b5536.pdf | Published version | 1.1 MB | Adobe PDF | View/Open |
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