Please use this identifier to cite or link to this item:
http://hdl.handle.net/1942/30296
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jaworski, Tomasz | - |
dc.contributor.author | DEWACHTER, Ilse | - |
dc.contributor.author | Seymour, Claire Marie | - |
dc.contributor.author | Borghgraef, Peter | - |
dc.contributor.author | Devijver, Herman | - |
dc.contributor.author | Kügler, Sebastian | - |
dc.contributor.author | Van Leuven, Fred | - |
dc.date.accessioned | 2020-01-13T11:02:29Z | - |
dc.date.available | 2020-01-13T11:02:29Z | - |
dc.date.issued | 2010 | - |
dc.date.submitted | 2020-01-09T11:45:33Z | - |
dc.identifier.citation | Biochimica et biophysica acta, 1802 (10) , p. 808-18 -818 (Art N° SI) | - |
dc.identifier.uri | http://hdl.handle.net/1942/30296 | - |
dc.description.abstract | Alzheimer's dementia is developing ever more as a complex syndrome with various unknown genetic and epigenetic contributions. These are compounded on and exacerbating the underlying amyloid and tau pathology that remain the basis of the pathological definition of Alzheimer's disease. Here, we present a selection of aspects of recent bigenic and virus-based mouse strains, developed as pre-clinical models for Alzheimer's disease. We discuss newer features in the context of the characteristics defined in previously validated transgenic models. We focus on specific aspects of single and multiple transgenic mouse models for Alzheimer's disease and for tauopathies, rather than providing an exhaustive list of all available models. We concentrate on the content of information related to neurodegeneration and disease mechanisms. We pay attention to aspects and defects that are predicted by the models and can be tested in humans. We discuss implications that help translate the fundamental knowledge into clinical, diagnostic and therapeutic applications. We elaborate on the increasing knowledge extracted from transgenic models and from newer adeno-associated viral models. We advocate this combination as a valuable strategy to study molecular, cellular and system-related pathogenic mechanisms in AD and tauopathies. We believe that innovative animal models remain needed to critically test current views, to identify and validate therapeutic targets, to allow testing of compounds, to help understand and eventually treat tauopathies, including Alzheimer's disease. | - |
dc.description.sponsorship | The investigations were made possible by funding and supportfrom the Fonds voor Wetenschappelijk Onderzoek-Vlaanderen (FWO-Vlaanderen), the Instituut voor Wetenschap en Techniek (IWT), theEEC-6th and 7th Framework Programs, the Rooms-fund, the KULeu-ven-Research Fund (BOF) and KULeuven-Research&Development. Wesincerely thank many collaborators and scientists for technicalassistance, advice, materials and scientific or moral support.TJ was the recipient of EU-Marie Curie doctoral fellowship (MEST-CT-2005-020589, EURON PhD School for Neurosciences).CMS is supported by EU-FP7-MEM.Stick (HEALTH-F2M-2007-201600).IDW is senior scientist at FWO-Vlaanderen | - |
dc.language.iso | en | - |
dc.publisher | ELSEVIER | - |
dc.rights | 2010 Elsevier B.V. All rights reserved | - |
dc.subject.other | Alzheimer | - |
dc.subject.other | Transgenic | - |
dc.subject.other | Adeno-associated virus | - |
dc.subject.other | Neurodegeneration | - |
dc.subject.other | Tauopathy | - |
dc.subject.other | Neurofibrillary tangles | - |
dc.title | Alzheimer's disease: old problem, new views from transgenic and viral models | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 818 | - |
dc.identifier.issue | 10 | - |
dc.identifier.spage | 808-18 | - |
dc.identifier.volume | 1802 | - |
local.bibliographicCitation.jcat | A1 | - |
local.publisher.place | RADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | SI | - |
dc.source.type | Review | - |
dc.identifier.doi | 10.1016/j.bbadis.2010.03.005 | - |
dc.identifier.pmid | 20332023 | - |
dc.identifier.isi | 000281827600004 | - |
local.provider.type | PubMed | - |
local.uhasselt.uhpub | no | - |
item.fullcitation | Jaworski, Tomasz; DEWACHTER, Ilse; Seymour, Claire Marie; Borghgraef, Peter; Devijver, Herman; Kügler, Sebastian & Van Leuven, Fred (2010) Alzheimer's disease: old problem, new views from transgenic and viral models. In: Biochimica et biophysica acta, 1802 (10) , p. 808-18 -818 (Art N° SI). | - |
item.fulltext | With Fulltext | - |
item.accessRights | Restricted Access | - |
item.contributor | Jaworski, Tomasz | - |
item.contributor | DEWACHTER, Ilse | - |
item.contributor | Seymour, Claire Marie | - |
item.contributor | Borghgraef, Peter | - |
item.contributor | Devijver, Herman | - |
item.contributor | Kügler, Sebastian | - |
item.contributor | Van Leuven, Fred | - |
Appears in Collections: | Research publications |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
1-s2.0-S0925443910000645-main.pdf Restricted Access | Published version | 1.86 MB | Adobe PDF | View/Open Request a copy |
SCOPUSTM
Citations
40
checked on Sep 2, 2020
WEB OF SCIENCETM
Citations
37
checked on Oct 5, 2024
Page view(s)
26
checked on Sep 7, 2022
Download(s)
4
checked on Sep 7, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.