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http://hdl.handle.net/1942/30301
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DC Field | Value | Language |
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dc.contributor.author | Everaerts, Wouter | - |
dc.contributor.author | Gees, Maarten | - |
dc.contributor.author | Alpizar, Yeranddy A | - |
dc.contributor.author | Farre, Ricard | - |
dc.contributor.author | Leten, Cindy | - |
dc.contributor.author | Apetrei, Aurelia | - |
dc.contributor.author | DEWACHTER, Ilse | - |
dc.contributor.author | van Leuven, Fred | - |
dc.contributor.author | Vennekens, Rudi | - |
dc.contributor.author | De Ridder, Dirk | - |
dc.contributor.author | Nilius, Bernd | - |
dc.contributor.author | Voets, Thomas | - |
dc.contributor.author | Talavera, Karel | - |
dc.date.accessioned | 2020-01-13T13:36:04Z | - |
dc.date.available | 2020-01-13T13:36:04Z | - |
dc.date.issued | 2011 | - |
dc.date.submitted | 2020-01-09T11:43:43Z | - |
dc.identifier.citation | Current biology : CB, 21 (4) , p. 316 -321 | - |
dc.identifier.uri | http://hdl.handle.net/1942/30301 | - |
dc.description.abstract | Mustard oil (MO) is a plant-derived irritant that has been extensively used in experimental models to induce pain and inflammation. The noxious effects of MO are currently ascribed to specific activation of the cation channel TRPA1 in nociceptive neurons. In contrast to this view, we show here that the capsaicin receptor TRPV1 has a surprisingly large contribution to aversive and pain responses and visceral irritation induced by MO. Furthermore, we found that this can be explained by previously unknown properties of this compound. First, MO has a bimodal effect on TRPA1, producing current inhibition at millimolar concentrations. Second, it directly and stably activates mouse and human recombinant TRPV1, as well as TRPV1 channels in mouse sensory neurons. Finally, physiological temperatures enhance MO-induced TRPV1 stimulation. Our results refute the dogma that TRPA1 is the sole nocisensor for MO and motivate a revision of the putative roles of these channels in models of MO-induced pain and inflammation. We propose that TRPV1 has a generalized role in the detection of irritant botanical defensive traits and in the coevolution of multiple mammalian and plant species. | - |
dc.description.sponsorship | We would like to thank Joe ̈lle N. Chabwine for the help in setting up the DRGneuron cultures, Melissa Benoit and Sara Kerselaers for the genotyping andanimal work, Benoit Lechat for the help with the open-field behavioralexperiments, and all members of the Laboratory of Ion Channel Researchfor helpful suggestions. This work was supported by grants from the BelgianFederal Government (IUAP P6/28), the Research Foundation-Flanders(FWO) (G.0565.07 and G.0686.09), the Astellas European Foundation Award2009, and the Research Council of the KU Leuven (GOA 2009/07, EF/95/010,and PFV/10/006). W.E. and M.G. are doctoral fellows, K.T. is a postdoctoralfellow, and D.D.R. is a fundamental-clinical fellow of the FWO. | - |
dc.language.iso | en | - |
dc.publisher | CELL PRESS | - |
dc.rights | 2011 Elsevier Ltd. All rights reserved. | - |
dc.subject.other | Rat Urinary-Bladder | - |
dc.subject.other | Potential Channels | - |
dc.subject.other | Ion-Channel | - |
dc.subject.other | Functional-Characterization | - |
dc.subject.other | Chemical Nociception | - |
dc.subject.other | Trpa1 | - |
dc.subject.other | Pain | - |
dc.subject.other | Cold | - |
dc.subject.other | Transduction | - |
dc.subject.other | Inflammation | - |
dc.title | The capsaicin receptor TRPV1 is a crucial mediator of the noxious effects of mustard oil | - |
dc.type | Journal Contribution | - |
dc.identifier.epage | 321 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 316 | - |
dc.identifier.volume | 21 | - |
local.bibliographicCitation.jcat | A1 | - |
local.publisher.place | 50 HAMPSHIRE ST, FLOOR 5, CAMBRIDGE, MA 02139 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
dc.source.type | Article | - |
dc.identifier.doi | 10.1016/j.cub.2011.01.031 | - |
dc.identifier.pmid | 21315593 | - |
dc.identifier.isi | 000287767600025 | - |
dc.identifier.eissn | 1879-0445 | - |
local.provider.type | PubMed | - |
local.uhasselt.uhpub | no | - |
item.fullcitation | Everaerts, Wouter; Gees, Maarten; Alpizar, Yeranddy A; Farre, Ricard; Leten, Cindy; Apetrei, Aurelia; DEWACHTER, Ilse; van Leuven, Fred; Vennekens, Rudi; De Ridder, Dirk; Nilius, Bernd; Voets, Thomas & Talavera, Karel (2011) The capsaicin receptor TRPV1 is a crucial mediator of the noxious effects of mustard oil. In: Current biology : CB, 21 (4) , p. 316 -321. | - |
item.fulltext | With Fulltext | - |
item.accessRights | Restricted Access | - |
item.contributor | Everaerts, Wouter | - |
item.contributor | Gees, Maarten | - |
item.contributor | Alpizar, Yeranddy A | - |
item.contributor | Farre, Ricard | - |
item.contributor | Leten, Cindy | - |
item.contributor | Apetrei, Aurelia | - |
item.contributor | DEWACHTER, Ilse | - |
item.contributor | van Leuven, Fred | - |
item.contributor | Vennekens, Rudi | - |
item.contributor | De Ridder, Dirk | - |
item.contributor | Nilius, Bernd | - |
item.contributor | Voets, Thomas | - |
item.contributor | Talavera, Karel | - |
crisitem.journal.issn | 0960-9822 | - |
crisitem.journal.eissn | 1879-0445 | - |
Appears in Collections: | Research publications |
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1-s2.0-S0960982211000546-main.pdf Restricted Access | Published version | 1.08 MB | Adobe PDF | View/Open Request a copy |
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