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Title: | Breastfeeding predicts blood mitochondrial DNA content in adolescents | Authors: | COSEMANS, Charlotte NAWROT, Tim JANSSEN, Bram VRIENS, Annette SMEETS, Karen Baeyens, Willy BRUCKERS, Liesbeth Den Hond, Elly Loots, Ilse Nelen, Vera Van Larebeke, Nicolas Schoeters, Greet MARTENS, Dries PLUSQUIN, Michelle |
Issue Date: | 2020 | Publisher: | Nature Research | Source: | Scientific Reports, 10 (Art N° 387) | Abstract: | Nutrition during early childhood is linked to metabolic programming. We hypothesized that breastfeeding has long-term consequences on the energy metabolism exemplified by mitochondrial DNA (mtDNA). As part of the third cycle of the Flemish Environment and Health Study (FLEHSIII) cohort, 303 adolescents aged 14–15 years were included. We associated breastfeeding and blood mtDNA content 14–15 years later while adjusting for confounding variables. Compared with nonbreastfed adolescents, mtDNA content was 23.1% (95%CI: 4.4–45.2; p = 0.013) higher in breastfed adolescents. Being breastfed for 1–10 weeks, 11–20 weeks, and >20 weeks, was associated with a higher mtDNA content of respectively 16.0% (95%CI: −7.1–44.9; p = 0.191), 23.5% (95%CI: 0.8–51.3; p = 0.042), and 31.5% (95%CI: 4.3–65.7; p = 0.021). Our study showed a positive association between breastfeeding and mtDNA content in adolescents which gradually increased with longer periods of breastfeeding. Higher mtDNA content may be an underlying mechanism of the beneficial effects of breastfeeding on children’s metabolism. | Keywords: | Peripheral-Blood;Socioeconomic-Status;Pubertal Changes;Mothers Milk;Copy Number;Association;Melatonin;Heart;Dysfunction;Diseases | Document URI: | http://hdl.handle.net/1942/30331 | ISSN: | 2045-2322 | e-ISSN: | 2045-2322 | DOI: | 10.1038/s41598-019-57276-z | ISI #: | WOS:000551445800003 | Rights: | Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. | Category: | A1 | Type: | Journal Contribution | Validations: | ecoom 2021 |
Appears in Collections: | Research publications |
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Cosemans C (2020) - Breastfeeding predicts blood mitochondrial DNA content in adolescents.pdf | Published version | 1.21 MB | Adobe PDF | View/Open |
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