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http://hdl.handle.net/1942/30332
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DC Field | Value | Language |
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dc.contributor.author | Pierrot, Nathalie | - |
dc.contributor.author | Ris, Laurence | - |
dc.contributor.author | STANCU, Ilie Cosmin | - |
dc.contributor.author | Doshina, Anna | - |
dc.contributor.author | Ribeiro, Floriane | - |
dc.contributor.author | Tyteca, Donatienne | - |
dc.contributor.author | Baugé, Eric | - |
dc.contributor.author | Lalloyer, Fanny | - |
dc.contributor.author | Malong, Liza | - |
dc.contributor.author | Schakman, Olivier | - |
dc.contributor.author | Leroy, Karelle | - |
dc.contributor.author | Kienlen-Campard, Pascal | - |
dc.contributor.author | Gailly, Philippe | - |
dc.contributor.author | Brion, Jean-Pierre | - |
dc.contributor.author | DEWACHTER, Ilse | - |
dc.contributor.author | Staels, Bart | - |
dc.contributor.author | Octave, Jean-Noël | - |
dc.date.accessioned | 2020-01-17T08:08:55Z | - |
dc.date.available | 2020-01-17T08:08:55Z | - |
dc.date.issued | 2019 | - |
dc.date.submitted | 2020-01-09T10:31:14Z | - |
dc.identifier.citation | Life science alliance, 2 (2) (Art N° ARTN e201800262) | - |
dc.identifier.issn | 2575-1077 | - |
dc.identifier.uri | http://hdl.handle.net/1942/30332 | - |
dc.description.abstract | Mechanisms driving cognitive improvements following nuclear receptor activation are poorly understood. The peroxisome proliferator-activated nuclear receptor alpha (PPARα) forms heterodimers with the nuclear retinoid X receptor (RXR). We report that PPARα mediates the improvement of hippocampal synaptic plasticity upon RXR activation in a transgenic mouse model with cognitive deficits. This improvement results from an increase in GluA1 subunit expression of the alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor, eliciting an AMPA response at the excitatory synapses. Associated with a two times higher PPARα expression in males than in females, we show that male, but not female, PPARα null mutants display impaired hippocampal long-term potentiation. Moreover, PPARα knockdown in the hippocampus of cognition-impaired mice compromises the beneficial effects of RXR activation on synaptic plasticity only in males. Furthermore, selective PPARα activation with pemafibrate improves synaptic plasticity in male cognition-impaired mice, but not in females. We conclude that striking sex differences in hippocampal synaptic plasticity are observed in mice, related to differences in PPARα expression levels. | - |
dc.description.sponsorship | We thank the Fondation Louvain for support to N Pierrot; the Netherlands Brain Bank for providing us with human brain samples; F Saez-Orellana, PhD (IoNS, Brussels, Belgium), for discussion; and Pr. L Hue for his critical evaluation of the results and editing the manuscript. This work was supported by the Belgian Fonds pour la Recherche Scientifique, Interuniversity Attraction Poles Program-Belgian State-Belgian Science Policy, The Belgian Fonds de la Recherche Scientifique Medicale, the Queen Elisabeth ´ Medical Foundation, and the Fondation pour la Recherche sur la Maladie d’Alzheimer. | - |
dc.language.iso | en | - |
dc.publisher | LIFE SCIENCE ALLIANCE LLC | - |
dc.rights | 2019 Pierrot et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/ licenses/by/4.0/). | - |
dc.title | Sex-regulated gene dosage effect of PPARα on synaptic plasticity | - |
dc.type | Journal Contribution | - |
dc.identifier.issue | 2 | - |
dc.identifier.volume | 2 | - |
local.bibliographicCitation.jcat | A1 | - |
local.publisher.place | 1 BUNGTOWN RD, COLD SPRING HARBOR, NY 11724 USA | - |
local.type.refereed | Refereed | - |
local.type.specified | Article | - |
local.bibliographicCitation.artnr | ARTN e201800262 | - |
dc.source.type | Article | - |
dc.identifier.doi | 10.26508/lsa.201800262 | - |
dc.identifier.pmid | 30894406 | - |
dc.identifier.isi | 000466600900015 | - |
dc.identifier.eissn | 2575-1077 | - |
local.provider.type | PubMed | - |
local.uhasselt.uhpub | yes | - |
local.uhasselt.international | yes | - |
item.fulltext | With Fulltext | - |
item.validation | ecoom 2020 | - |
item.accessRights | Open Access | - |
item.fullcitation | Pierrot, Nathalie; Ris, Laurence; STANCU, Ilie Cosmin; Doshina, Anna; Ribeiro, Floriane; Tyteca, Donatienne; Baugé, Eric; Lalloyer, Fanny; Malong, Liza; Schakman, Olivier; Leroy, Karelle; Kienlen-Campard, Pascal; Gailly, Philippe; Brion, Jean-Pierre; DEWACHTER, Ilse; Staels, Bart & Octave, Jean-Noël (2019) Sex-regulated gene dosage effect of PPARα on synaptic plasticity. In: Life science alliance, 2 (2) (Art N° ARTN e201800262). | - |
item.contributor | Pierrot, Nathalie | - |
item.contributor | Ris, Laurence | - |
item.contributor | STANCU, Ilie Cosmin | - |
item.contributor | Doshina, Anna | - |
item.contributor | Ribeiro, Floriane | - |
item.contributor | Tyteca, Donatienne | - |
item.contributor | Baugé, Eric | - |
item.contributor | Lalloyer, Fanny | - |
item.contributor | Malong, Liza | - |
item.contributor | Schakman, Olivier | - |
item.contributor | Leroy, Karelle | - |
item.contributor | Kienlen-Campard, Pascal | - |
item.contributor | Gailly, Philippe | - |
item.contributor | Brion, Jean-Pierre | - |
item.contributor | DEWACHTER, Ilse | - |
item.contributor | Staels, Bart | - |
item.contributor | Octave, Jean-Noël | - |
Appears in Collections: | Research publications |
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File | Description | Size | Format | |
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e201800262.full.pdf | Published version | 2.63 MB | Adobe PDF | View/Open |
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